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Allergen Immunotherapy
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Your search returned 14 results
from the time period: last 90 days.
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The Journal of allergy and clinical immunology
SQ HDM SLIT-tablet significantly increased serum HDM-specific IgG4 and IgE blocking factor, and significantly decreased early phase nasal symptoms after nasal allergen challenge. No significant effects on cytokines or gene expression in nasal mucosa were observed.
Contact dermatitis
Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens. The response to a mixture of allergens can be both additive and synergistic, depending on the dose and combination of allergens. Importantly, sensitization with combinations of either fragrance allergens or metal salts can result in increased challenge responses to specific allergens within the mixture. Taken together, the immune responses to mixtures of allergens are complex, and further studies are required to obtain the necessary knowledge to improve consumer safety.
Dermatology (1)
Allergic Contact Dermatitis (1), more mentions
AbstractText: The European Academy of Allergy and Clinical Immunology (EAACI) is developing guidelines for allergen immunotherapy (AIT) for the management of allergic rhinitis, allergic asthma, IgE-mediated food allergy and venom allergy. To inform the development of clinical recommendations, we undertook systematic reviews to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT for these conditions.
Allergy (8), Rhinitis (6), Asthma (6), more mentions
AbstractText: The European Academy of Allergy and Clinical Immunology (EAACI) has produced Guidelines on Allergen Immunotherapy (AIT. We sought to gauge the preparedness of primary care to participate in the delivery of AIT in Europe AbstractText: We undertook a mixed-methods, situational analysis. This involved a purposeful literature search, and two surveys: one to primary care clinicians and the other ...
Allergy (2), more mentions
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
... review AbstractText: Advantages and drawbacks of pure and defined recombinant allergens and peptides over allergen extracts in the context of allergy research, diagnosis, and allergen immunotherapy are discussed ... The possibility of prophylactic vaccination based on recombinant fusion proteins consisting of viral carrier proteins and allergen-derived peptides without allergenic activity are also discussed AbstractText: During ... sequences were determined, which led to a production of recombinant allergens that mimic biochemically and immunologically their natural counterparts.
Vaccines (2)
Allergy (4), more mentions
Abstract: Regulatory approaches for allergen immunotherapy (AIT) products and the availability of high-quality AIT products are inherently linked to each other... Several challenges for AIT products are apparent from this analysis and will require further consideration Keyword: allergen immunotherapy. Keyword: allergic diseases. Keyword: allergy. Keyword: regulation.
Allergy (1), more mentions
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
OBJECTIVE: To review the manufacturing procedures of food allergen extracts and applicable regulatory requirements from government agencies, potential approaches to standardization, and clinical application of these products. The effects of thermal processing on allergenicity of common food allergens are also considered. DATA SOURCES: A broad literature review was conducted on the natural history of food allergy, the manufacture of allergen extracts, and the allergenicity of heated food. Regulations, guidance documents, and pharmacopoeias related to food allergen extracts from the United States and Europe were also reviewed. STUDY SELECTIONS: Authoritative and peer-reviewed research articles relevant to the topic were chosen for review. Selected regulations and guidance documents are current and relevant to food allergen extracts. RESULTS: Preparation of a food allergen extract may require careful selection and identification of source materials, grinding, defatting, extraction, clarification, sterilization, and product testing. Although extractions for all products licensed in the United States are performed using raw source materials, many foods are not consumed in their raw form. Heating foods may change their allergenicity, and doing so before extraction may change their allergenicity and the composition of the final product. CONCLUSION: The manufacture of food allergen extracts requires many considerations to achieve the maximal quality of the final product. Allergen extracts for a select number of foods may be inconsistent between manufacturers or unreliable in a clinical setting, indicating a potential area for future improvement.
Food Hypersensitivity (2), more mentions
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
... MS method is valuable for absolute quantification of allergens in GCr extracts and likely has broader applicability to other complex allergen extracts. Definitive quantification provides a new standard for labelling of allergen extracts, which will inform patient care, enable personalized therapy, and enhance the efficacy of immunotherapy for environmental and food allergies Keyword: German cockroach allergens. Keyword: LC-MRM MS.
Food Hypersensitivity (1), Allergy (1), more mentions
The Journal of allergy and clinical immunology
Clinical trials of oral immunotherapy (OIT) are strengthened by using standardized peanut preparations with defined doses of major allergens AbstractText: This article describes measurement of Ara h 1, Ara h 2, and Ara h 6 in peanut foods and in peanut flour extracts used for allergy diagnosis and OIT AbstractText ...
Allergy (1), more mentions
PloS one
However, the majority of allergen candidates could not be assigned as clear orthologs to known mite allergens. The genomic sequence data, predicted proteome, and allergen homologs identified from E. maynei provide insight into the relationships among astigmatid mites and their allergens, which should allow for the development of improved diagnostics and immunotherapy.
Allergy (2), Scabies (1), more mentions
A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune ...
Oncology (5)
Neoplasms (5), Allergy (4), more mentions
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
AbstractText: Subcutaneous allergen immunotherapy with grass pollen allergoids has been proven to be effective and safe in the treatment of patients with allergic rhinoconjunctivitis... Keyword: allergen immunotherapy. Keyword: allergoid. Keyword: dose-finding. Keyword: placebo-controlled double-blind study. Keyword: rhinoconjunctivitis. Keyword: subcutaneous immunotherapy. Keyword: type-1 allergy.
Allergy (1), more mentions
The Journal of allergy and clinical immunology
In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
Allergy (2), more mentions
AbstractText: A relevant proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after successfully completing allergen immunotherapy (AIT... Keyword: subcutaneous allergen immunotherapy.
Seasonal Allergic Rhinitis (1), more mentions