... study was to describe the microbiological and clinical characteristics of orthopedicimplant-associated infections caused by F. magnaMethods: We retrospectively analyzed samples consisting of ... and samples already identified as F. magna from patients with orthopedicinfections... revealed that the isolates clustered into two distinct clades.Conclusions: Orthopedicimplant-associated infections caused by F. magna are rare, but the bacteria are ...
Infectious Diseases (6), Muscular and Skeletal Diseases (5) Infections (8), more mentions
We hypothesized that infections after totalhip arthroplasty (THA) and total knee arthroplasty (TKA) lead to excess readmissions and increased costs. This study aims to evaluate the proportion of readmissions due to infections following THA and TKA.Healthcare Cost and Utilization Project-State Inpatient Databases were used for the study.
AbstractText: Diabeticfootosteomyelitis is a major risk factor for amputation... cohort study was to assess prospectively the remission rate of diabeticfootosteomyelitis medically treated using white blood cell (WBC)-single-photon emission ... CT) as a predictive marker of remission AbstractText: Individuals with diabeticfootosteomyelitis that was non-surgically treated between April 2014 and December ...
... defensin proteins in synovial fluid using the Synovasure lateral flow device and to determine its diagnostic reliability and accuracy compared with the prostheticjointinfection (PJI) criteria produced by the Musculoskeletal Infection Society (MSIS) AbstractText: A cohort of 121 patients comprising 85 total knee arthroplasties and 36 ... Keyword: Prostheticjointinfection.
The study aimed to retrospectively assess if strain typing of Propionibacterium acnes could help to distinguish between infection and contamination in isolates recovered from the central nervous system (CNS) and prosthetic joints (PJs). This was a retrospective cohort of all Propionibacterium species isolates from the Barnes-Jewish Hospital (St Louis, MO, USA) clinical microbiology laboratory from 2011 to 2014. Available frozen isolates were recovered, and strain type (IA-1, IA-2, IB, II, III, or nontypeable class A or B) was determined via polymerase chain reaction (PCR)-based methods. For CNS isolates, P. acnes was considered pathogenic if treating physicians administered ≥7 days of directed antibiotic therapy against P. acnes. During the study period, Propionibacterium species was isolated from clinical cultures 411 times. 152 isolates were available for analysis. Of the 152 isolates, 140 were confirmed to be P. acnes, 61 of which were from the CNS (45 contaminants, 16 infections). Strain type IA-1 was more common (50.0%, 8 out of 16) among CNS infections than among contaminants (22.2%, 10 out of 45). For PJ isolates 61.3% (19 out of 31) met the criteria for infection. The predominant strain type for CNS infection was IA-1 and for PJ isolates, IB. Strain type IA-1 was isolated more often in patients with CNS infections, which may indicate a predilection of this strain type to cause CNS infection. Future research should prospectively evaluate strain typing as a means of assisting in the diagnosis of CNS infections and confirm our findings.
BACKGROUND: Cardiovascular implantable electronic devices (CIEDs) can be life-saving. However, complications from CIED infection can be life-threatening often requiring device removal. Despite publication of CIED infection management guidelines there remains marked variation in clinical practice.
OBJECTIVE: To better understand and quantify these differences, we conducted a multi-national survey of practitioners of CIED management.
METHODS: An electronic survey was sent to Heart Rhythm Society members, spanning 70 countries across six continents. All responses were collected anonymously.
RESULTS: 227 out of 3,600 (6.3%) responded to the survey. The majority of surveys were completed by practitioners from the US (168; 68.3%) and 53.8% of these practiced in academic medical centers. The large majority (92.7%) of sites had protocols to ensure appropriate timing of prophylactic antibiotics. Superficial (incisional) site infections were treated with antibiotics alone 52.5% of the time (consistent with guidelines); in contrast, deep pocket infections were treated with antibiotics (with device removal) in accordance to guidelines only 37.4% of the time. Almost all providers (98.7%) were inclined to perform complete hardware removal in cases of CIED-related endocarditis. In contrast, 82.2% of survey participants suggested complete CIED system removal in patients with an occult Gram-positive bacteremia, 65.5% with occult Gram-negative bacteremia, and 59.3% with prolonged bacteremia due to a source other than CIED.
CONCLUSIONS: These data suggest wide variability in clinical practice in managing CIED infection with significant deviations from published guidelines. There is critical need to increase awareness and develop institutional protocols to ensure adherence with evidence-based guidelines to optimize outcomes. This article is protected by copyright. All rights reserved.
... would be of benefit to clinicians involved in management of diabeticfoot infections AbstractText: A combination of literature review with expert discussion was used to generate consensus on management of diabeticfoot infection, with a specific focus on empirical antimicrobial therapy AbstractText: Gram positive organisms represent the commonest pathogens in diabeticfoot infection ...
Infectious Diseases (10), Endocrine Disorders (8) Diabetic Foot (8), Infections (7), Drug Hypersensitivity (1), more mentions
Hypertension, ischemic heart disease, cerebrovascular disease, and peripheral vascular disease were identified as predictive variables of higher major amputation rates AbstractText: Although further investigation of long-term and prospective studies is needed, we identified four variables as predisposing factors for higher major amputation in diabetic patients through meta-analysis Keyword: Accompanying disease. Keyword: Amputation. Keyword: Diabeticfoot. Keyword: Risk factor.
JAK3 is a tyrosine kinase essential for signaling downstream of the common gamma chain subunit shared by multiple cytokine receptors. JAK3 deficiency results in T(-)B(+)NK(-) severe combined immune deficiency (SCID). We report a patient with SCID due to a novel mutation in the JAK3 JH4 domain. The function of the JH4 domain remains unknown. This is the first report of a missense mutation in the JAK3 JH4 domain, thereby demonstrating the importance of the JH4 domain of JAK3 in host immunity.
Osteomyelitis (1), Severe Combined Immunodeficiency (1), more mentions