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Sepsis/Septic Shock
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Your search returned 25 results
from the time period: last 90 days.
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JAMA 
AbstractText: The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknown AbstractText: To determine whether ... Patients were randomized 1:1 to either (1) an early resuscitation protocol for sepsis (n = 107) that included intravenous fluid bolus administration with monitoring ... In the 6 hours after presentation to the emergency department, patients in the sepsis protocol group received a median of 3.5 L (interquartile range ...
Immune System Diseases (1)
Sepsis (12), Hypotension (5), Infections (1), more mentions
Infectious diseases (London, England)
ICU mortality was compared between the patient group fulfilling Sepsis-3 definition for septic shock and those that met Sepsis-2 ... Serum lactate values ≥6 mmol/L, were significantly associated with increased ICU mortality.Patients classified according to Sepsis-3 criteria had a higher ICU mortality compared with Sepsis-2 criteria ...
Sepsis (11), Septic Shock (6), more mentions
The Journal of emergency medicine
... article is to determine the preferred intravenous fluid for the resuscitation of patients with severe sepsis and septic shock AbstractText: A MEDLINE literature review was completed to identify studies that investigated the type of resuscitation fluid in the management of patients with severe sepsis and septic shock ... systemic reviews AbstractText: Crystalloids are the preferred solution for the resuscitation of emergency department patients with severe sepsis and septic shock.
Sepsis (10), Septic Shock (6), more mentions
The Journal of emergency medicine
The authors then systematically evaluated each study, which formed the basis for this clinical statement AbstractText: Patients with severe sepsis and septic shock should receive early and appropriate antibiotics in the emergency department. Patients with septic shock who received appropriate antimicrobial therapy within 1 h of recognition had the greatest benefit in mortality Keyword: antibiotic.
Infectious Diseases (7)
Septic Shock (6), Sepsis (6), more mentions
British journal of anaesthesia
ICU admissions identified either as Sepsis-3 sepsis or septic shock and as Sepsis-2 severe sepsis or septic shock had ... The predictive validity was greatest for Sepsis-3 septic shock AbstractText: In an ICU database, compared with Sepsis-2, Sepsis-3 identifies a similar sepsis population with 92% overlap and ...
Sepsis (34), Septic Shock (13), more mentions
Chest
AbstractText: To assess the agreement between transpulmonary thermodilution (TPT) and critical care echocardiography (CCE) in ventilated patients with septic shock AbstractText: Ventilated patients in sinus rhythm requiring advanced hemodynamic assessment for septic shock were included in this prospective multicenter descriptive study. Patients were assessed successively using TPT and CCE in random order.
Septic Shock (3), Pulmonary Heart Disease (1), more mentions
The Journal of emergency medicine
... septic shock in this specific population are limited AbstractText: We aimed to evaluate the clinical presentation and factors associated with outcome among ESRD patients with acute septic shock AbstractText: We reviewed patients prospectively enrolled in an emergency department (ED) septic shock treatment pathway registry between January 2014 and May 2016.
Kidney Disease (5), Men's Health (3)
Chronic Kidney Failure (20), Septic Shock (12), Infections (1), more mentions
Current opinion in critical care
... We reviewed the recent advances in the initial approach to resuscitation of sepsis and septic shock patients AbstractText: Sepsis and septic shock are life-threatening emergencies ... vasopressor, and inotrope selection remains limited AbstractText: Though the early resuscitation of sepsis and septic shock is key to improving outcomes, ideal resuscitation targets are elusive ...
Infectious Diseases (1)
Septic Shock (7), Sepsis (5), Infections (1), more mentions
The Annals of pharmacotherapy
AbstractText: Severe sepsis and septic shock represent common presentations in the emergency department (ED) and have high rates of mortality. Guideline-recommended goals of care have been shown to benefit these patients, but can be difficult to provide AbstractText: To determine whether the use of a premixed bag consisting of 2 g cefepime and 1 g vancomycin in 1000 mL ...
Infectious Diseases (6), Men's Health (3)
Sepsis (8), Septic Shock (5), more mentions
The Journal of hospital infection
BACKGROUND: Sepsis is one of the leading causes of death in the UK. AIMS: The aims of this study were to identify the rate of inactive antimicrobial therapy (AMT) in the ICU and whether inactive AMT had an effect on in hospital mortality, ICU mortality, 90-day mortality and length of hospital stay. Additionally, we wanted to identify risk factors for receiving inactive AMT. METHODS: This was a retrospective observational study conducted at Glasgow Royal Infirmary ICU between January 2010 and December 2013, with 12,000 blood cultures taken over this time period, of which n=127 were deemed clinically significant. Multivariate logistic regression was used to identify risk factors independently associated with mortality. To identify risk factors for receiving inactive AMT a univariable and a subsequent multivariate analysis was constructed. RESULTS: The rate of inactive AMT was 47% (n =60). Our multivariate analysis showed that receiving antibiotics within the first 24 hours of ICU admission led to a reduced mortality (RR 1.70; 95% CI 1.19-2.44.) Furthermore, it showed that severity of illness (as defined by SIRS criteria sepsis vs septic shock) increased mortality (OR 9.87; 95% CI 1.73-55.5). However, inactive AMT did not increase mortality (OR 1.07; 95% CI 0.47-2.41) or length of hospital stay (53.2 vs 69.1 days p=0.348.) We identified fungal bloodstream infection as a risk factor for receiving inactive AMT (OR 5.10;95% CI 1.29-20.14. CONCLUSION: Mortality from sepsis is influenced by multiple factors. We were unable to demonstrates that inactive AMT had an effect on mortality in sepsis.
Infectious Diseases (1)
Sepsis (5), Infections (2), Septic Shock (1), more mentions
The American journal of emergency medicine
STUDY OBJECTIVE: Quantify the correlation between blood pressure variability (BPV) and markers of illness severity: serum lactate (LAC) or Sequential Organ Failure Assessment (SOFA) scores. METHODS: We performed a secondary analysis of data from a prospective, observational study evaluating fluid resuscitation on adult, septic, ED patients. Vital signs and fluid infusion volumes were recorded every 15min during the 3h following ED arrival. BPV was assessed via average real variability (ARV): the average of the absolute differences between consecutive BP measurements. ARV was calculated for the time periods before and after 3 fluid infusion milestones: 10-, 20-, and 30-mL/kg total body weight (TBW). Spearman's rho correlation coefficient analysis was utilized. A p-value<0.05 was considered statistically significant. RESULTS: Forty patients were included. Mean fluid infusion was 33.7mL/kg TBW (SD 22.1). All patients received fluid infusion≥10mL/kg TBW, 25 patients received fluid infusion>20mL/kg TBW, and 16 patients received fluid infusion>30mL/kg TBW. Mean initial LAC was 4.0mmol/L (SD 3.2). Mean repeat LAC was 3.1mmol/L (SD 3.2), obtained an average of 6.6h (SD 5.3) later. Mean SOFA score was 7.0 (SD 4.4). BPV correlated with both follow-up LAC (r=0.564; p=0.023) and SOFA score (r=0.544; p=0.024) among the cohort that received a fluid infusion>20-mL/kg TBW. CONCLUSION: With the finding of a positive correlation between BPV and markers of illness severity (LAC and SOFA scores), this pilot study introduces BPV analysis as a real-time, non-invasive tool for continuous sepsis monitoring in the ED.
Men's Health (3)
Sepsis (2), more mentions
PloS one
... to decide on the ideal course of action AbstractText: This study aims to evaluate the performance of Mortality in Emergency Department Sepsis Score (MEDS), Modified Early Warning Score (MEWS), Rapid Emergency Medicine Score (REMS) and Rapid Acute Physiology Score (RAPS) for predicting the mortality risk of adult splenic abscess patients ...
Men's Health (3)
Abscesses (6), Sepsis (2), more mentions
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Short Course of Empirical Gentamicin in Patients With Severe Sepsis and Septic Shock in the ICU: A Benefit or a Burden?.
Septic Shock (2), Sepsis (2), more mentions
Infectious diseases (London, England)
Correction to: Driessen et al., The influence of a change in septic shock definitions on intensive care epidemiology and outcome: comparison of sepsis-2 and sepsis-3 definitions..
Sepsis (4), Septic Shock (2), more mentions
Journal of intensive care medicine
The SOFA is complex and unfamiliar to most emergency physicians, while qSOFA is insensitive for sepsis screening and may result in missed cases of sepsis ... easy-to-use simple SOFA score for use in the emergency department (ED) AbstractText: Retrospective study of ED patients with sepsis with in-hospital mortality as the primary outcome ...
Men's Health (2)
Sepsis (9), Infections (1), Septic Shock (1), more mentions
Emergency medicine Australasia : EMA 
... challenging due to the heterogeneity of the syndrome, and the lack of an objective standard diagnostic test. While overall mortality rates from sepsis appear to be falling, there is an increasing burden of morbidity among survivors. This largely reflects the growing proportion of older patients with comorbid illnesses among those treated for sepsis Keyword: emergency service. Keyword: hospital. Keyword: sepsis.
Men's Health (1)
Sepsis (6), Infections (1), more mentions
PloS one
OBJECTIVE: Due to atypical symptom presentation older patients are more prone to delayed sepsis recognition. We investigated whether initial disease severity before emergency department (ED) treatment (including treatable acute organ dysfunction), quality of ED sepsis care and the impact on mortality was different between patients older and younger than 70 years. If differences exist, improvements are needed for ED management of older patients at risk for sepsis. METHODS: In this observational multicenter study, ED patients who were hospitalized with a suspected infection were stratified by age <70 and ≥70 years. The presence of treatable and potentially reversible acute organ dysfunction was measured by the RO components of the Predisposition, Infection, Response and Organ dysfunction (PIRO) score, reflecting acute sepsis-related organ dysfunction developed before ED presentation. Quality of care, as assessed by the full compliance with nine quality performance measures and the standardized mortality ratio (SMR: observed/expected in-hospital mortality), was compared between older and younger patients. RESULTS: The RO-components of the PIRO score were 8 (interquartile range; 4-9) in the 833 older patients, twice as high as the 4 (2-8; P<0.001) in the 1537 younger patients. However, full compliance with all nine quality performance measures was achieved in 34.2 (31.0-37.4)% of the older patients, not higher than the 33.0 (30.7-35.4)% in younger patients (P = 0.640). In-hospital mortality was 9.2% (95%-CI, 7.3-11.2) in patients ≥70, twice as high as the 4.6% (3.6-5.6) in patients <70 years, resulting in an SMR (in study period) of ~0.7 in both groups (P>0.05). CONCLUSION: Older sepsis patients are sicker at ED presentation but are not treated more expediently or reliably despite their extra acuity The presence of twice as much treatable acute organ dysfunction before ED treatment suggests that acute organ dysfunction is recognized relatively late by general practitioners or patients in the out of hospital setting.
Men's Health (6)
Sepsis (6), Infections (1), more mentions
BMJ open
The SepsiVit study aims to determine whether continuous heart rate variability (HRV) measurement can provide an early warning for deterioration in patients presenting with suspected infection or sepsis to the emergency department (ED) AbstractText: The protocol of a prospective observational study in the ED. We will include 171 adult medical patients presenting with suspected infection or sepsis and at least ...
Men's Health (2)
Sepsis (5), Infections (3), Systemic Inflammatory Response Syndrome (1), more mentions
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Sepsis begins outside of the hospital for nearly 80% of patients and the emergency room (ER) represents the first contact with the health care system. This study evaluates a project to improve collection of blood cultures (BCs) in patients with sepsis in the ER consisting of staff education and completion of the appropriate BC pre-analytical phase. A retrospective observational study performed to analyse the data on BC collection in the ER before and after a three-phase project. The first phase (1 January to 30 June 2015) before the intervention consisted of evaluation of data on BCs routinely collected in the ER. The second phase (1 July to 31 December 2015) was the intervention phase in which educational courses on sepsis recognition and on pre-analytical phase procedures (including direct incubation) were provided to ER staff. The third phase (1 January to 30 June 2016; after the intervention) again consisted of evaluation. Before the intervention, out of 24,738 admissions to the ER, 103 patients (0.4%) were identified as septic and had BCs drawn (359 BC bottles); 19 out of 103 patients (18.4%) had positive BCs. After the intervention, out of 24,702 admissions, 313 patients (1.3%) had BCs drawn (1,242 bottles); of these, 96 (30.7%) had positive BCs. Comparing the first and third periods, an increase in the percentage of patients with BCs collected (from 0.4% to 1.3% respectively, p < 0.0001) and an increase in the percentages of patients with true-positive BCs (from 0.08% to 0.39% of all patients evaluated respectively, p < 0.0001) were observed. The isolation of bacteria by BCs increased 3.25-fold after project implementation. These results can be principally ascribed to an improved awareness of sepsis in the staff associated with improved pre-analytical phase procedures in BC collection.
Sepsis (6), Infections (1), more mentions
The American journal of emergency medicine
Comparison of six scoring systems for predicting the mortality of severe sepsis patients in emergency department..
Sepsis (2), more mentions
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