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Your search returned 18 results
from the time period: last 90 days.
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Acta anaesthesiologica Scandinavica
... assessed the value of standard biochemical coagulation parameters in predicting bleeding, thrombosis and mortality in adult Intensive Care Unit (ICU) patients with haematological malignancies AbstractText: We screened all patients with ... INR was the only variable we found associated with subsequent bleeding within 24 h from admission to ICU (odds ratio 2.91, 95% CI: 1.01-8.43, P = 0.048 ...
Thrombosis (4), Infections (1), Myelodysplastic Syndromes (1), more mentions
Journal of neurotrauma
Our aim was to describe current approaches and to quantify variability between European intensive care units (ICU)s in patients with TBI. Therefore, we conducted a provider profiling survey as part of the 'Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury' (CENTER-TBI) study. The ICU Questionnaire was sent to 68 centers from 20 countries across Europe and Israel. For this study, we used ICU questions focused on 1) hemoglobin target level (Hb-TL), 2) coagulation management, and 3) deep venous thromboembolism (DVT) prophylaxis. Sixty-six centers completed the ICU questionnaire. For ICU-patients, half of the centers (N= 34; 52%) had a defined Hb-TL in their protocol. For patients with TBI, 26 centers (41%) indicated a Hb-TL between 70 and 90 g/l and 38 centers (59%) above 90 g/l. To treat trauma related hemostatic abnormalities the use of fresh frozen plasma (N= 48; 73%) or platelets (N= 34; 52%) was most often reported, followed by the supplementation of vitamin K (N= 26; 39%). Most centers reported using DVT prophylaxis with anticoagulants frequently or always (N= 62; 94%). In the absence of hemorrhagic brain lesions, 14 centers (21%) delayed DVT prophylaxis until 72 hours after trauma. If hemorrhagic brain lesions were present, the number of centers delaying DVT prophylaxis for 72 hours increased to 29 (46%). Overall, a lack of consensus exists between European ICUs on blood transfusion and coagulation management. The results provide a baseline for the CENTER-TBI study and the large between-center variation indicates multiple opportunities for comparative effectiveness research.
Cardiovascular Diseases (1)
Traumatic Brain Injuries (9), Craniocerebral Trauma (1), Venous Thromboembolism (1), more mentions
3. Acquired Bleeding Disorders.  
Date: 10/28/2017
Hematology/oncology clinics of North America
Emergency medicine practitioners treat bleeding patients on a regular basis... Other acquired causes of abnormal hemostasis include renal disease, immune thrombocytopenia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, acquired coagulation factor inhibitors, acute traumatic coagulopathy, liver disease, and disseminated intravascular coagulopathy.
Kidney Disease (1)
Thrombocytopenia (1), Liver Diseases (1), Thrombotic Thrombocytopenic Purpura (1), more mentions
Annals of emergency medicine
AbstractText: We determine whether omitting the pelvic examination in emergency department (ED) evaluation of vaginal bleeding or lower abdominal pain in ultrasonographically confirmed early intrauterine pregnancy is equivalent to performing the examination AbstractText: We conducted a prospective, open-label, randomized, equivalence trial in pregnant patients presenting to the ED from ...
Men's Health (2)
Vaginal Bleeding (3), Infections (1), more mentions
Hematology/oncology clinics of North America
Patients presenting to the emergency department with acute bleeding and a history of clotting or platelet disorder present a unique challenge to the emergency physician. The severity of bleeding presentation is based on mechanism as well as factor levels: patients with factor levels greater than 5% can respond to most minor hemostatic challenges, whereas those with factor levels less than ...
The American journal of medicine
It Takes More than Just a Finger to Determine Emergency Room Disposition for Possible Gastrointestinal Bleeding..
Scandinavian journal of gastroenterology
AbstractText: Upper gastrointestinal bleeding (UGIB) is a frequent medical emergency and several scoring systems are developed to help risk-stratify patients. We aimed to investigate if elevated arterial lactate (AL) was associated with 30-day mortality, need for hospital-based intervention, or rebleeding. Furthermore, we compared the performance of AL with existing scoring systems and examined if incorporation of AL ...
Gastrointestinal Hemorrhage (1), more mentions
British journal of anaesthesia
Acute traumatic coagulopathy: pathophysiology and resuscitation..
BMJ open
... no longer be appropriate for the diagnosis of sepsis-associated coagulopathy... to evaluate prognostic factors in patients diagnosed with sepsis and coagulopathy according to the new sepsis definition and assess their accuracy ... value of the newly proposed diagnostic criteria for sepsis-induced coagulopathy (SIC. A total of 1498 Japanese patients with sepsis and coagulopathy complications who were treated with recombinant thrombomodulin were analysed in ...
Sepsis (9), Systemic Inflammatory Response Syndrome (1), more mentions
Journal of intensive care medicine
Patients on single AP therapy (either aspirin or clopidogrel) did not differ from those on no AP therapy in any TEG parameters measured.Dual AP therapy is associated with a detectable coagulopathy which may have implications in the management of patients with AIS and hemorrhagic stroke. The effects of single AP therapy may not be demonstrated by TEG.
Cardiovascular Diseases (4)
Stroke (2), Acute Stroke (2), Cerebral Hemorrhage (1), more mentions
Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran Following Trauma..
Journal of inherited metabolic disease
... leads to a range of symptoms, including hepatic dysfunction and coagulopathy. This study evaluated the incidence and severity of coagulopathy and the effect of vitamin K supplementation orally and IV ... from the medical records of 30 ZSD patients to study coagulopathy and the effect of vitamin K orally on proteins induced ...
Vitamin K Deficiency (2), Liver Diseases (1), more mentions
Current opinion in critical care
... study was to discuss the recent developments in trauma-induced coagulopathy and the evolvement of goal-directed therapy AbstractText: Mortality from ... The pathophysiology of coagulopathy in trauma reflects at least two distinct mechanisms: Acute traumatic coagulopathy, consisting of endogenous heparinization, activation of the protein C pathway, hyperfibrinolysis and platelet dysfunction, and resuscitation associated coagulopathy ...
Journal of thrombosis and haemostasis : JTH
... of only 1% plasma fibrinogen in coagulopathic blood would generate 90 nm soluble fibrin, far exceeding ~1 nmGPVI in blood. Soluble fibrin, rather than thrombin-induced platelet activation throuh PAR-1 and PAR-4, downregulated GPVI-signaling in response to stimuli, and may lead to subsequent hypofunction of endogenous or transfused platelets Keyword: GPVI. Keyword: coagulopathy. Keyword: fibrin. Keyword: platelet.
Shock (Augusta, Ga.)
Abstract: Trauma patients are often affected by a hypocoagulable condition referred as trauma-induced coagulopathy (TIC) for which few therapeutic options exist. One available treatment is fresh platelets transfusion, although, It is not efficacious enough and it has a number of limitations; therefore, we reviewed the literature to propose an alternative therapy based on platelet-derived microvesicles (PMVs), which are ...
Thrombosis (1), more mentions
Journal of cardiothoracic and vascular anesthesia
Currently, numerous POC tests are available for evaluating hemostasis. The purpose of this review is to provide a comprehensive evaluation of the current evidence surrounding the most common POC testing devices in practice for managing coagulation Keyword: Blood transfusion. Keyword: Coagulation tests. Keyword: Coagulopathy. Keyword: Hemostasis. Keyword: Platelet function assays. Keyword: Point of care tests.
Journal of orthopaedic trauma
AbstractText: To evaluate the ability of measures of coagulopathy and acidosis to predict complications. We hypothesize that increased coagulopathy and acidosis over the first 60 hours of hospitalization will ... of acidosis: pH, lactate, and base excess, and measures of coagulopathy: PT, PTT, INR, and platelets... Incidence of coagulopathy increased over 48 hours (16.3% to 34.3.
Acidosis (8), Sepsis (4), Infections (3), more mentions
Journal of cardiothoracic and vascular anesthesia
Comparing Factor Concentrates for Post-Bypass Coagulopathy: Is There One Best Option?.