RATIONALE: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of low malignant potential. The most frequent site of IMT is in the lung, whereas recurrent and metastasis of thyroid IMT has been seldom reported.
PATIENT CONCERNS: A 57-year-old male presented with a 3-year history of painless thyroid mass. The physical examination revealed a diffusely enlarged thyroid which was firm. The thyroid function and antibodies were normal. Thyroid ultrasound revealed a hypoechoic mass in the left lobe and heterogeneous echo in the right lobe. Neck computed tomography showed a diffused enlargement of thyroid with the homogeneously low intensity and the moderate enhancement.
DIAGNOSES: A diagnosis of thyroid IMT was made according the postoperative histological and immunohistochemical analysis.
INTERVENTIONS: The patient underwent subtotal thyroidectomy. Seventeen months after the surgery, the patients presented with a firm nodule of right adductor magnus and a relapsing mass of thyroid. Needle core biopsy of the thyroid mass suggested the relapsing of thyroid IMT. The mass excision of the right adductor magnus was performed and an IMT was confirmed by histopathology. The patient underwent thyroid radiation therapy and steroid therapy.
OUTCOMES: The size of the tumor was smaller than the preradiation size and the patient is now under follow-up.
LESSONS: This is the seldom reported patient with recurrent thyroid IMT with metastasis. IMT of the thyroid is an unusual but distinct disease entity. The clinical and radiological features are not specific and its diagnosis is based on the histological features. Although tumor resection and radiation seem to be effective, no standard treatment for such disease has been established.
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... 2012 AbstractText: To assess the effects of bisphosphonates and other bone agents in addition to anti-cancer treatment: (i) in women with early breast cancer (EBC); (ii) in women with advanced breast cancer without bone metastases (ABC); and (iii) in women with metastatic breast cancer and bone metastases (BCBM) AbstractText: In this review update, we searched Cochrane ...
Oncology (9) Breast Neoplasms (8), Bone Resorption (1), Neoplasms (1), more mentions
Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma AbstractText: We ... reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014... 4 complication AbstractText: Cryoablation can be effective for achieving local oncologic control in bone metastases from renal cell carcinoma and may represent a valuable alternative to surgical metastasectomy in ...
The estimated required margins were 7.9 and 3.3 mm and increased by 53.9% and 2.5% of V5Gy(RBE), respectively, compared with planning AbstractText: TM ensured a better dose distribution than did BM. To enable TM, volumetric imaging is crucial and should replace 2D radiographs for carbon therapy of stage I lung cancer Keyword: Bone matching. Keyword: Carbon ion radiotherapy.
Blood tests revealed anemia and thrombocytopenia, and pathological results of a bone marrow biopsy confirmed the metastatic carcinoma AbstractText: It was diagnosed as an OBC based on the positive immunohistochemical staining of cytokeratin (CK) and gross cystic disease fluid protein-15 (GCDFP-15) AbstractText: Doctor advised her to check whether ...
Oncology (6), Blood Disorders and Hematology (3) Anemia (3), Thrombocytopenia (3), Breast Neoplasms (3), more mentions
Abstract: Transforming acidic coiled-coil-containing protein 3 (TACC3), a microtubule regulator, is associated with various cancers. However, the relationship between TACC3 and softtissuesarcomas (STS) remains unclear. We investigated the expression of TACC3 in 136 STS patient samples using immunohistochemical (IHC) staining, and the statistical associations between TACC3 expression and clinicopathological characteristics were evaluated.
We describe the multi-platform molecular landscape of 206 adult softtissuesarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (TP53 ...
AbstractText: Because recurrence is high after pulmonary metastasectomy (PM) for softtissuesarcoma (STS), repeat PM is commonly performed. Our objective was to define the selection criteria for repeat PM among patients experiencing recurrence and to identify factors associated with survival AbstractText: We reviewed a prospectively maintained database of 539 patients undergoing PM for STS.
AbstractText: Softtissuesarcomas are rare neoplasms that can occur in the thoracic wall, abdominal wall, extremities, and inguinal region. Wide local resection, with precise histological margin control, results in large skin defects that are challenging to close. Various repair procedures, such as vertical rectus abdominis flaps (VRAM), latissimus dorsi flaps, and tensor fascia lata (TFL) flaps are used to ...
AbstractText: Soft-tissuesarcomas (STS) are a group of rare, heterogeneous and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies... Keyword: softtissuesarcoma. Keyword: survival.
Oncology (4) Sarcoma (4), Leiomyosarcoma (1), Neoplasms (1), more mentions
... has shown that it can also be used for many other malignancies AbstractText: A 71-year-old male with a neuroendocrine tumor (NET) of unknown origin showed osteoblastic bone metastases positive to F-CH PET AbstractText: Diffuse bone and liver metastases were gallium-DOTATOC PET-positive with only mild uptake ...
... study was to determine the relevance of standardized uptake value (SUV) on [F]fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), focusing on tumor and bone marrow, to disease outcomes based on progression-free survival (PFS) and overall survival (OS) in patients with diffuse large B-cell lymphoma (DLBCL) receiving ...
AbstractText: Postoperative deep infection after bonetumor surgery remains a serious complication... is only a small number of reports about those for bonetumor surgery... aimed to identify risk factors for postoperative deep infection after bonetumor resection AbstractText: We reviewed data of 681 patients (844 bonetumors) who underwent surgery ...
To report perioperative and oncological outcomes of patients with nodal and bone involvement treated with postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and simultaneous bone resection (BR).Between 2008 and 2016, 14 consecutive unselected TC patients with nodal and bone involvement underwent PC-RPLND and BR. Surgery was performed together with orthopedic surgeons.
Muscular and Skeletal Diseases (2), Oncology (1) Necrosis (2), Neoplasms (2), Teratoma (2), more mentions
We compared the oncological outcomes of sphincter-saving resection (SSR) and abdominoperineal resection (APR) in 409 consecutive patients with very low rectal cancer (i.e., tumors within 3 cm from the anal verge); 335 (81.9%) patients underwent APR and 74 (18.1%) underwent SSR. The APR group comprised higher proportions of men (67.5% vs 55.4%, P = .049) and advanced-stage patients (P < .001). Preoperative chemoradiotherapy (PCRT) was more frequently administered in the SSR group (83.8% vs 52.8%, P < .001). Overall, the systemic and local recurrence rates were 29.1% and 6.1%, respectively. On stratification according to PCRT and pathologic stage, the mode of surgery did not affect the recurrence type. Moreover, recurrence-free survival (RFS) did not differ according to the mode of surgery in different cancer stages. RFS was associated with ypT and ypN stages in patients who received PCRT, while pN stage, lymphovascular invasion (LVI), and circumferential resection margin (CRM) involvement were risk factors for RFS in those who did not receive PCRT. Notably, SSR was not found to be a risk factor for RFS in either subgroup. Patients who were stratified according to cancer stage and PCRT also showed no differences in RFS according to the mode of surgery. Our results demonstrate that, regardless of PCRT administration, SSR is an effective treatment for very low rectal cancer, while CRM is an important prognostic factor for patients who did not receive PCRT.
... intraosseous failure after stereotactic body radiation therapy (SBRT) for coxal bonemetastasis AbstractText: Patients treated with SBRT to coxal bonemetastasis were identified by retrospective chart review ... the recurrent tumor and the nearest edge of the initial bonemetastasis in cases of marginal/out-of-field recurrence AbstractText: Seventeen ... defining the optimal clinical target volume in SBRT for coxal bonemetastasis to obtain sufficient local tumor control is difficult.
Oncology (6) Neoplasms (4), Renal Cell Carcinoma (1), more mentions
RATIONALE: Detection of skull metastases is as important as detection of brain metastases because early diagnosis of skull metastases is a crucial determinant of treatment. However, the skull can be a blind spot for assessing metastases on routine brain magnetic resonance imaging (MRI). To the best of our knowledge, the finding of skull metastases on arterial spin labeling (ASL) has not been reported. ASL is a specific MRI sequence for evaluating cerebral blood flow using magnetized endogenous inflow blood. This study uses ASL as a routine sequence of brain MRI protocol and describes 3 clinical cases of skull metastases identified by ASL. The study also highlights the clinical usefulness of ASL in detecting skull metastases.
PATIENT CONCERNS: Three patients with known malignancy underwent brain MRI to evaluate for brain metastases.
DIAGNOSES: All of the skull metastases were conspicuously depicted on routine ASL images, and the lesions correlated well with other MRI sequences.
INTERVENTIONS: Three patients received palliative chemotherapy.
OUTCOMES: Three patients are being followed up regularly at the outpatient department.
LESSONS: The routine use of ASL may help to detect lesions in blind spots, such as skull metastases, and to facilitate the evaluation of intracranial pathologies without the use of contrast materials in exceptional situations.
Oncology (2) Neoplasm Metastasis (1), Skull Base Neoplasms (1), more mentions
RATIONALE: Post-therapy or diagnostic whole-body radioiodine scintigraphy is widely employed to evaluate the residual, recurrence, or metastases of differentiated thyroid carcinoma because of the high sensitivity and accuracy. However, it has pitfalls.
PATIENT CONCERNS: We described a 63-year-old male with a history of papillary thyroid carcinoma who was referred for iodine-131 ablation therapy. The post-therapy iodine-131 whole-body images demonstrated abnormal increased uptake of the tracer in the regions of bilateral upper abdomen.
DIAGNOSES: The single photon emission computed tomography/computed tomography (SPECT/CT) showed the abnormal Iactivity was corresponded to multiple irregular cystic low densities in the both kidneys on the low-dose computed tomography images, so the diagnosis of polycystic kidney disease was confirmed.
INTERVENTIONS AND OUTCOMES: The patient responded well to the lifestyle-based treatments.
LESSONS: Polycystic kidney disease was one of the etiologies of the false-positive findings in the radioiodine scintigraphy.