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Carbapenem-Resistant Superbugs
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Your search returned 17 results
from the time period: last 90 days.
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Antimicrobial agents and chemotherapy
Against Enterobacteriaceae isolates displaying carbapenem-resistant Enterobacteriaceae (CRE) (n = 265), multidrug-resistant (MDR) (n = 1,210), and extensively drug-resistant (XDR) (n = 161) phenotypes, meropenem-vaborbactam displayed MIC50/90 values of 0.5/32, 0.03/1, and 0.5/32 μg/ml, respectively, whereas meropenem activities were 16/>32, 0.06/32, and ...
Infection control and hospital epidemiology
Carbapenem-Resistant Enterobacteriaceae: A Strategic Roadmap for Infection Control-CORRIGENDUM..
Infections (2), more mentions
Digestive diseases and sciences
BACKGROUND: Numerous published outbreaks, including one from our institution, have described endoscope-associated transmission of multidrug-resistant organisms (MDROs). Individual centers have adopted their own protocols to address this issue, including endoscope culture and sequestration. Endoscope culturing has drawbacks and may allow residual bacteria, including MDROs, to go undetected after high-level disinfection. AIM: To report the outcome of our novel protocol, which does not utilize endoscope culturing, to address our outbreak. METHODS: All patients undergoing procedures with elevator-containing endoscopes were asked to permit performance of a rectal swab. All endoscopes underwent high-level disinfection according to updated manufacturer's guidance. Additionally, ethylene oxide (EtO) sterilization was done in the high-risk settings of (1) positive response to a pre-procedure risk stratification questionnaire, (2) positive or indeterminate CRE polymerase chain reaction (PCR) from rectal swab, (3) refusal to consent for PCR or questionnaire, (4) purulent cholangitis or infected pancreatic fluid collections. Two endoscopes per weekend were sterilized on a rotational basis. RESULTS: From September 1, 2015 to April 30, 2016, 556 endoscopy sessions were performed using elevator-containing endoscopes. Prompted EtO sterilization was done on 46 (8.3%) instances, 3 from positive/indeterminate PCR tests out of 530 samples (0.6%). No CRE transmission was observed during the study period. Damage or altered performance of endoscopes related to EtO was not observed. CONCLUSION: In this pilot study, prompted EtO sterilization in high-risk patients has thus far eliminated endoscope-associated MDRO transmission, although no CRE infections were noted throughout the institution during the study period. Further studies and a larger patient sample will be required to validate these findings.
Infections (2), Cholangitis (1), more mentions
Journal of clinical microbiology
... and Acinetobacter baumannii, is necessary to prevent their dissemination within health care settings. We performed a method comparison study of 11 phenotypic carbapenemase detection assays to evaluate their accuracy for the detection of CPNFs. A total of 96 carbapenem-resistant glucose-nonfermenting isolates were included, of which 29% produced carbapenemases... Keyword: carbapenem-resistant. Keyword: carbapenem-resistant organisms. Keyword: carbapenemase-producing.
Antimicrobial agents and chemotherapy
Minocycline, a semi-synthetic tetracycline developed in the 1970s, has become an important treatment option against MDR A. baumannii infections, particularly those caused by carbapenem-resistant strains (1).…..
Infections (1), more mentions
Journal of clinical microbiology
Enterobacter cloacae is an important nosocomial bacteria that is prevalent in hospital intensive care units (ICUs) (1-4).….
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Importance of carbapenemase production detection in Carbapenem Resistant Enterobacteriaceae. Looking beyond epidemiological purposes..
American journal of infection control 
Abstract: In this study, we retrospectively evaluated clinical outcomes of 75 patients with dual colistin- and carbapenem-resistant Klebsiella pneumoniae bloodstream infections over a 5-year period in a single tertiary care hospital in ... Our findings indicate the urgent need for new antibiotics to treat these infections Keyword: Carbapenem resistance.
Infectious Diseases (1)
Infections (3), more mentions
The Lancet. Infectious diseases 
All five representative carbapenem-resistant K pneumoniae strains belonged to the ST11 type, which is the most prevalent carbapenem-resistant K pneumoniae type in China, and originated from the same ... Genomic analyses showed that the emergence of these ST11 carbapenem-resistant hypervirulent K pneumoniae strains was due to the acquisition of ...
Infectious Diseases (2)
Infections (2), Pneumonia (1), Community-Acquired Infections (1), more mentions
The Lancet. Infectious diseases 
Convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae..
Emerging infectious diseases
During 2013-2016, we isolated blaNDM- and blaVIM-harboring Enterobacteriaceae and nonfermentative bacteria from patients in the Philippines. Of 130 carbapenem-resistant isolates tested, 45 were Carba NP-positive; 43 harbored blaNDM, and 2 harbored blaVIM. Multidrug-resistant microbial pathogen surveillance and antimicrobial drug stewardship are needed to prevent further spread of New Delhi metallo-β-lactamase variants.
Antimicrobial agents and chemotherapy
... by Acinetobacter baumannii, especially in the Northwest United States where carbapenem resistant A. baumannii remain relatively rare. However, between June 2012 and October 2014, an outbreak of carbapenem-resistant A. baumannii occurred in 16 patients from 5 healthcare facilities ... isolate to gain insight into the genetic location of the carbapenem resistance gene.
Infectious Diseases (1)
Infections (1), more mentions
Antimicrobial agents and chemotherapy
Their 30-day mortality rate was 57.0%, and the carbapenem resistance rate of their isolates was 87.0. Among patients with carbapenem-resistant Acinetobacter bacteremia, breakthrough bacteremia during carbapenem therapy was associated with a significantly higher 14-day mortality (51.7% versus 37.4%, respectively; P = 0.025 by bivariate analysis) and a higher ...
Bacteremia (11), more mentions
Intensive care medicine
In the last decade, antibiotic stewardship and infection prevention and control have been unable to prevent the rapid spread of resistant Gram-negative bacteria (GNB), in particular carbapenem-resistant Pseudomonas aeruginosa (and other non-fermenting GNB), extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant Enterobacteriaceae (CRE. The situation appears more optimistic currently for Gram-positive, where Staphylococcus aureus, and ...
Infectious Diseases (6), Vaccines (1)
Infections (3), more mentions
15. Sparing carbapenem usage.  
Date: 06/22/2017
The Journal of antimicrobial chemotherapy
AbstractText: Carbapenem resistance in Gram-negative bacteria is increasing in many countries and use of carbapenems and antibiotics to which resistance is linked should be reduced to slow its emergence. There are no directly equivalent antibiotics and the alternatives are less well supported by clinical trials. The few new agents are expensive AbstractText: To provide guidance on strategies to reduce ...
Infectious Diseases (3)
Infections (1), more mentions
Antimicrobial agents and chemotherapy
... important CHDLs have been identified in A. baumannii, including OXA-23, OXA-24/40, OXA-58, OXA-143, OXA-235, and the chromosomally encoded OXA-51. The selection and dissemination of carbapenem-resistant A. baumannii strains constitutes a serious global threat. Carbapenems have been successfully utilized as last resort antibiotics for the treatment of multi-drug-resistant A. baumannii infections.
Infectious Diseases (1)
Infections (3), more mentions
Emerging infectious diseases
During antimicrobial drug resistance testing for Vibrio spp. from coastal waters of Germany, we identified 4 nontoxigenic, carbapenem-resistant V. cholerae isolates. We used whole-genome sequencing to identify the carbapenemase gene blaVCC-1. In addition, a molecular survey showed that more blaVCC-1-harboring isolates are present in coastal waters of Germany.