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Pediatric Urology
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Your search returned 71 results
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International journal of surgery (London, England)
OBJECTIVES: To report the results of a novel surgical technique for achieving urinary continence in patients with bladder exstrophy complex (BEC) by ureteric-urethral engraftment (UUE) technique. PATIENTS AND METHODS: Sixteen female patients with BEC and a mean ± SD age of 3.48 ± 1.75 years were referred for primary exstrophy repair from 2009 to 2012. From these, 9 patients were operated by single-stage bladder closure (group I); while 7 patients underwent the novel technique of UUE to compare the continence achievement (group II). In UUE technique, distal ureter was applied for total urethral replacement while the lower part of engraft was fixed in external genitalia. No osteotomy was performed in none of the groups. Continence and upper urinary tract evaluation were performed in the follow-ups with 3 months intervals for the first year and biannually thereafter. The patients were followed-up for a mean ± SD duration of 72 ± 6 months. RESULTS: All patients in both groups experienced an uneventful postoperative period. In group II, 5 patients were continent day and night and voided per urethra without need for augmentation or intermittent catheterization technique (71.42%); while 55.55% of patients in group I achieved total continence (n = 5). Partial continence was achieved in 4 (44.44%) and 2 (28.57%) patients in group I and II, respectively. However, 3 patients in UUE group had postoperative vesicoureteral reflux that was successfully managed by Deflux injection. CONCLUSION: The eventual clinical outcomes of BEC children undergoing the UUE technique were promising. This practicable, safe, and reproducible option will add one complementary stage to the previously used reconstruction techniques. These patients would necessitate further surveillance with upper urinary tract evaluations during the adult life.
Urology (4), Pediatrics (1)
Bladder Exstrophy (3), Urinary Incontinence (1), Vesico-Ureteral Reflux (1), more mentions
Results of this analysis showed that compared with childhood-onset SLE, pulmonary involvement was significantly higher with adult-onset SLE (RR: 1.51, 95% CI: 1.18-1.93; P = .001), whereas renal involvement was significantly higher with childhood-onset SLE (RR: 0.65, 95% CI: 0.55-0.77; P = .00001. Raynaud phenomenon and photosensitivity were significantly higher in adult-onset SLE (RR: 1.29, 95 ...
Immune System Diseases (2), Blood Disorders and Hematology (1)
Systemic Lupus Erythematosus (2), Raynaud Phenomenon (1), Pleurisy (1), more mentions
The Journal of urology
Re: Better Defining the Spectrum of Adult Hypospadias: Examining the Effect of Childhood Surgery on Adult Presentation..
Hypospadias (2), more mentions
4. This Month in Pediatric Urology.  
Date: 09/08/2017
The Journal of urology
This Month in Pediatric Urology..
Urology (2), more mentions
Pediatric research
... obstruction vs.ConclusionThis study shows, for the first time, the PDGFRα(+) cell expression in the human UPJ. Altered SK3 channel expression observed in PDGFRα(+) cells in UPJ obstruction suggests that the impairment of SK3 activity across the UPJ may perturb upper urinary tract peristalsis in this urological condition.Pediatric Research advance online publication, 13 September 2017; doi:10.1038/pr.2017.193.
Urology (1)
Hydronephrosis (1), more mentions
BACKGROUND: Starting resuscitation before clamping the umbilical cord at birth may progressively increase pulmonary blood flow while umbilical venous blood flow is still contributing to maintenance of oxygenation and left ventricle preload. OBJECTIVE: To evaluate the feasibility, safety, and effects of intact cord resuscitation (ICR) on cardiorespiratory adaptation at birth in newborn infants with CDH. STUDY DESIGN: Prospective, observational, single-center pilot study. METHODS: Physiologic variables and outcomes were collected prospectively in 40 consecutive newborn infants with an antenatal diagnosis of isolated CDH. RESULTS: Infants were managed with immediate cord clamping (ICC group) from 1/2012 to 5/2014 or the cord was clamped after initiation of resuscitation maneuvers (ICR group) from 6/2014 to 4/2016 (20 in each group). Ante- and postnatal markers of CDH severity were similar between groups. Resuscitation before cord clamping was possible for all infants in the ICR group. No increase in maternal or neonatal adverse events was observed during the period of ICR. The pH was higher and the plasma lactate concentration was significantly lower at one hour after birth in the ICR than in the ICC group (pH=7.17±0.1 vs 7.08±0.2; lactate=3.6±2.3 vs 6.6±4.3mmol/l, p<0.05). Mean blood pressure was significantly higher in the ICR than in the ICC group at H1 (52±7.7 vs 42±7.5mmHg), H6 (47±3.9 vs 40±5.6mmHg) and H12 (44±2.9 vs 39±3.3mmHg) (p<0.05). CONCLUSION: Commencing resuscitation and initiating ventilation while the infant is still attached to the placenta is feasible in infants with CDH. The procedure may support the cardiorespiratory transition at birth in infants with CDH.
Hernia (2), more mentions
The Journal of urology
CT scans may be over utilized in pediatric patients with renal trauma.We performed a retrospective chart review of all renal trauma cases (<18 years old) in ... to detect an abnormality requiring urologic intervention is 50% and 94%, respectively.Repeat CT scans in pediatric patients with renal trauma are common.
Pediatric radiology
A highly sensitive and radiation-free imaging modality, fMRU can provide detailed morphological and functional information that can facilitate conservative and/or surgical management of children with renal fusion anomalies. This paper reviews the embryological basis of the different types of renal fusion anomalies, their imaging appearances at fMRU, complications associated with fusion anomalies, and the important role of fMRU ...
Urology (3)
Urolithiasis (1), Congenital Abnormalities (1), Infections (1), more mentions
Critical care medicine
... between the production of cell-free plasma hemoglobin and acute kidney injury in infants and children undergoing cardiopulmonary bypass for cardiac surgery AbstractText: Prospective observational study ... during cardiopulmonary bypass and male gender are associated with subsequent renal dysfunction in low-risk pediatric patients, especially in those older than 2 years ...
Acute Kidney Injury (3), Hemolysis (1), more mentions
Pediatric nephrology (Berlin, Germany)
To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and quantity of FOXP3(+) T regulatory lymphocytes in diagnostic kidney biopsies from pediatric patients.A total of 33 patients (14 TIN and 19 TINU) were enrolled.
Uveitis (7), Tubulointerstitial Nephritis (2), more mentions
The early impact of renal transplantation on subclinical cardiovascular measures in pediatric patients has not been widely investigated. This analysis is performed for pediatric patients participating in the prospective 4C study and focuses on the early effects of RRT modality on cardiovascular comorbidity in patients receiving a preemptive transplant or started on dialysis.We compared measures indicating subclinical cardiovascular organ ...
Anti-Obesity and Weight Loss (2), Kidney Disease (1), Cardiovascular Diseases (1)
Chronic Kidney Failure (1), Hypertension (1), Obesity (1), more mentions
Acta paediatrica (Oslo, Norway : 1992)
AIM: The metabolic changes that occur during the postnatal weaning period appear to be particularly important for future health and breast milk is considered to provide the optimal source of infant nutrition. This pilot study from September 2013 to May 2015 examined the effect of breastfeeding on prostaglandin metabolism in healthy term infants. METHODS: Urine samples were collected from 19 infants at one month of age in the Juntendo University Hospital, Tokyo, Japan. The 13 infants in the breast-fed group received less than 540 mL/week of their intake from formula and the other nine were exclusively fed on formula. At six months we sampled 14 infants: six breastfed and five receiving formula. The infants were from normal single pregnancies and free from perinatal complications. We analysed urinary prostaglandin metabolites - tetranor prostaglandin E2 metabolite (t-PGEM) and tetranor prostaglandin D2 metabolite (t-PGDM) - using liquid chromatography tandem-mass spectrometry. RESULTS: Urinary t-PGDM excretion at one and six months was significantly lower in breast-fed infants than formula-fed infants. However, urinary t-PGEM excretion at one and six months was not significantly different between the groups. CONCLUSION: Our study showed that the type of feeding in early infancy affected prostaglandin metabolism in healthy term infants. This article is protected by copyright. All rights reserved.
Radiographics : a review publication of the Radiological Society of North America, Inc
Malignant renal tumors account for 7% of childhood cancers, and Wilms tumors are by far the most common-but not in older ... Knowledge of the clinical, biologic, and histopathologic features of renal tumors in older children and adolescents and their effects on the imaging appearance can help the radiologist offer ...
Oncology (2)
Neoplasms (5), Wilms Tumor (2), von Hippel-Lindau Disease (1), more mentions
Transplant international : official journal of the European Society for Organ Transplantation
AbstractText: Data about health-related quality of life (HRQOL) in adult recipients after pediatric kidney transplantation (KTx) are scarce AbstractText: In this nationwide questionnaire-based study, HRQOL and social status in young adult men having undergone KTx during childhood (n=29) was studied and compared to age- and gender-matched ...
Oncology (5)
Leukemia (4), Precursor Cell Lymphoblastic Leukemia-Lymphoma (1), more mentions
European journal of pediatrics
Lichen sclerosus is a chronic skin disease, mainly localised at the introitus and perineum. When the condition remains untreated, gradual atrophy of skin structures leads to permanent scarring, making early diagnosis and treatment crucial. We reviewed all patients diagnosed with lichen sclerosus presenting to a tertiary referral centre for paediatric and adolescent gynaecology between January 2011 and December 2015 to assess disease presentation and response to treatment. We identified 15 cases, with a mean age at diagnosis of 8.8 years. Their main presenting symptoms were vulvar pruritus and vulvar soreness. Seven girls had already atrophic changes, and in four girls, this amounted to clitoral phimosis, labial resorption or labial adhesion formation. The median delay in diagnosis was 7 months. Thirteen patients received local treatment with potent corticosteroids, responding well to treatment. However, 4 girls relapsed within 2 to 36 months. Two adolescents required surgical treatment, one because of urinary retention and the second because of dyspareunia caused by clitoral entrapment. CONCLUSIONS: There was a delay in diagnosis in most patients and this resulted in irreversible genital skin changes, which would have been preventable, had treatment been instituted promptly. The response to treatment with local corticosteroids was usually effective, leading to both symptom alleviation and prevention of disease progression. Atrophic changes and skin complications however were not reversed. What is Known: • Lichen sclerosus affects women of all ages, including girls, particularly prior to adolescence. • Lichen sclerosus responds well to local corticosteroid treatment. What is New: • In the majority of patients with lichen sclerosus there was a long delay between onset of symptoms and diagnosis. • Nearly half of the children diagnosed with lichen sclerosus had irreversible atrophic genital skin changes at the time of first presentation. These changes may have been prevented by a timely diagnosis and intervention.
Lichen Sclerosus et Atrophicus (8), Atrophy (2), Phimosis (2), more mentions
A time-to-event analysis with a Kaplan-Meier curve showed no significant differences between the three techniques AbstractText: Although CCC is an effective solution for children who cannot perform urethral catheterization, 52% requires surgical revision. Since no differences were found in outcome between APV, TBF and Monti, we conclude that a TBF CCC is a good alternative for the ...
Urology (2)
Pathologic Constriction (2), Neurogenic Urinary Bladder (1), more mentions
Only five cases of bilobed testis have been reported in the literature to date. This report is of bilateral, undescended, bilobed testes in a 15-month-old male who has multiple other malformations of possible genetic etiology Keyword: Bilobed Testes. Keyword: Cryptorchidism. Keyword: Pediatric Urology. Keyword: Polyorchidism. Keyword: Undescended Testes.
Urology (1)
Cryptorchidism (2), more mentions
Journal of perinatology : official journal of the California Perinatal Association
... 0.0001), but not with LA/Ao ratio (P=0.69) or blood flow velocity through the ductus (P=0.06).Our findings indicate that there is a positive correlation between ductal diameter and urinary NT-proBNP in preterm infants.Journal of Perinatology advance online publication, 14 September 2017; doi:10.1038/jp.2017.139.
Patent Ductus Arteriosus (2), more mentions
Pediatric research
BACKGROUND: Creatine is not included in commercial pediatric parenteral products; the entire creatine requirement must be met by de novo synthesis from arginine during parenteral nutrition (PN). Poor arginine status is common during PN in neonates which may compromise creatine accretion. We hypothesized that creatine supplementation will improve creatine status and spare arginine in PN-fed piglets. METHODS: Piglets (3-5 d old) were provided PN with or without creatine for 14 d. Tissue concentrations of creatine metabolites and activities of creatine synthesizing enzymes were measured as well as tissue protein synthesis rates and liver lipid parameters. RESULTS: Creatine provision lowered kidney and pancreas L-arginine:glycine amidinotransferase (AGAT, EC number activities and plasma guanidinoacetic acid (GAA) concentration, suggesting down-regulation of de novo creatine synthesis. Creatine increased plasma creatine concentrations to sow-fed reference levels and increased the creatine concentrations in most tissues, but not brain. PN creatine resulted in greater protein synthesis in the liver and in the kidney, but not in the pancreas, skeletal muscle or gut. Creatine supplementation also reduced liver cholesterol concentrations, but not triglyceride or total fat. CONCLUSIONS: The addition of creatine to PN may optimize the accretion of creatine and reduce the metabolic burden of creatine synthesis in rapidly growing neonates.Pediatric Research accepted article preview online, 28 August 2017. doi:10.1038/pr.2017.208.
The Journal of pediatrics
OBJECTIVE: To compare the efficacy and safety of lidocaine gel vs nonanesthetic gel (NAG) in reducing transurethral bladder catheterization (TUBC) procedural pain in children. STUDY DESIGN: A systematic literature search was done using electronic medical databases and trial registries up to September 2016 with no language restrictions. Randomized controlled trials (RCTs) that assessed the efficacy and safety of lidocaine gel vs NAG in reducing TUBC-associated pain in children were screened, identified, and appraised. Risks of bias and study quality of the eligible trials were assessed according to the Cochrane Collaboration recommendations. Various pain assessment scales from the included studies were extracted as mean differences and standard deviations for each treatment group. Standardized mean differences (SMDs) were generated with 95% CIs for between-group difference estimation. Effect estimates were pooled using the inverse variance method with a random-effects model. Subgroup analysis was performed for different age groups. RESULTS: Five RCTs (with a total of 369 children) were included. Overall pooled effect estimates showed that compared with NAG, lidocaine gel has no significant benefit in decreasing TUBC-associated pain in children (SMD, -0.22; 95% CI, -0.65 to 0.21). Effect estimates from 4 studies revealed no difference in pain reduction between the lidocaine gel and NAG in children aged <4 years (SMD, 0.01; 95% CI, -0.22 to 0.24). No serious adverse events from the lidocaine gel use were reported in any of the studies. CONCLUSIONS: Lidocaine gel does not appear to reduce TUBC pain compared with NAG, specifically in children aged <4 years. PROSPERO REGISTRATION NUMBER: CRD42016050018.
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