... erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatoryboweldiseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the ... 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatoryboweldiseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 ... conferred the highest cardiovascular risk and population impact, followed by inflammatoryboweldiseases Keyword: Arthritis.
Cardiovascular Diseases (6), Immune System Diseases (4), Muscular and Skeletal Diseases (1) Cardiovascular Diseases (5), Inflammatory Bowel Diseases (4), Rheumatoid Arthritis (3), more mentions
In addition, increased hepatic lipid content as well as impaired fasting proinsulin conversion at baseline ... detected phenotypes that independently predicted long-term glycaemic control AbstractText: Increased hepatic lipid content and impaired proinsulin conversion are new predictors, independent of ... to the confirmed factors, impaired insulin secretion and insulin sensitivity Keyword: Fattyliver.
Endocrine Disorders (4) Insulin Sensitivity (5), Diabetes Mellitus, Type 2 (2), Diabetes Mellitus (2), more mentions
Abstract: A major challenge in inflammatoryboweldisease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) using functional and regulatory annotations that relate to the cells ...
We combined blood tests for KRAS gene mutations with carefully thresholded protein biomarkers to determine whether the combination of these markers was superior to any single marker. The cohort tested included 221 patients with resectable pancreatic ductal adenocarcinomas and 182 control patients without known cancer... Keyword: pancreaticcancer. Keyword: protein biomarkers.
Common variant genome-wide association studies (GWASs) have, to date, identified >24 risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS comparing 6,476 PD cases with 302,042 controls, followed by a meta-analysis with a recent study of over 13,000 PD cases and 95,000 controls at 9,830 overlapping variants. We then tested 35 loci (P < 1 × 10(-6)) in a replication cohort of 5,851 cases and 5,866 controls. We identified 17 novel risk loci (P < 5 × 10(-8)) in a joint analysis of 26,035 cases and 403,190 controls. We used a neurocentric strategy to assign candidate risk genes to the loci. We identified protein-altering or cis-expression quantitative trait locus (cis-eQTL) variants in linkage disequilibrium with the index variant in 29 of the 41 PD loci. These results indicate a key role for autophagy and lysosomal biology in PD risk, and suggest potential new drug targets for PD.
Neurological and Central Nervous System Diseases (2) Parkinson Disease (2), more mentions
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Delivery of Health Care. DescriptorName: Epidemics. DescriptorName: Health Care Costs. DescriptorName: Healthcare Disparities. DescriptorName: Hepatitis C. DescriptorName: Humans. DescriptorName: Incidence. DescriptorName: Indians, North American. DescriptorName: United States. DescriptorName: United States Department of Veterans Affairs. DescriptorName: United States Indian Health Service. DescriptorName: Veterans.
... hospitals in London, Middlesex and Nottinghamshire AbstractText: A total of 444 patients aged 16-75 years seen in cardiology, endocrinology, gastroenterology, neurology and respiratory medicine clinics who scored ≥ 20 points on the Health Anxiety Inventory (HAI) and satisfied diagnostic requirements for ... Gastroenterology and cardiology patients showed the greatest CBT gains.
Neuroscience (3) Depressive Disorder (3), Hypochondriasis (1), more mentions
Abstract: Hepatitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae... Keyword: hepatitis B virus. Keyword: overlapping open reading frames. Keyword: viral gene evolution. Keyword: virus discovery. Keyword: virus origins. Keyword: virus-host long-term co-evolution.
Infectious Diseases (3) Hepatitis B (3), Contagious Ecthyma (2), more mentions
... impact of achieving forecasted coverages for vaccination against Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella ... lograr las coberturas previstas de vacunación frente a Haemophilus influenzae tipo b, hepatitis B, virus del papiloma humano, encefalitis japonesa, sarampión, Neisseria meningitidis serogrupo A ...
Vaccines (3), Infectious Diseases (2) Hepatitis B (2), Rubella (1), Japanese Encephalitis (1), more mentions
Fast food diet and energy expenditure profiles of the participants during the intervention were assessed as well as body composition (DXA), cardiometabolic profile (lipid, hepatic enzymes, glycated hemoglobin, glucose, insulin, hsC-reactive protein (hsCRP) and blood pressure) and estimated maximal oxygen consumption (VO2 max) pre- and post-experiment. We found significant improvements for fat mass, lean body mass, estimated VO₂ ...