BACKGROUND: Infectious diseases of wildlife are increasing worldwide with implications for conservation and human public health. The microbiota (i.e. microbial community living on or in a host) could influence wildlife disease resistance or tolerance. White-nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans (Pd), has killed millions of hibernating North American bats since 2007. We characterized the skin microbiota of naïve, pre-WNS little brown bats (Myotis lucifugus) from three WNS-negative hibernation sites and persisting, previously exposed bats from three WNS-positive sites to test the hypothesis that the skin microbiota of bats shifts following WNS invasion.
RESULTS: Using high-throughput 16S rRNA gene sequencing on 66 bats and 11 environmental samples, we found that hibernation site strongly influenced the composition and diversity of the skin microbiota. Bats from WNS-positive and WNS-negative sites differed in alpha and beta diversity, as well as in microbiota composition. Alpha diversity was reduced in persisting, WNS-positive bats, and the microbiota profile was enriched with particular taxa such Janthinobacterium, Micrococcaceae, Pseudomonas, Ralstonia, and Rhodococcus. Some of these taxa are recognized for their antifungal activity, and specific strains of Rhodococcus and Pseudomonas are known to inhibit Pd growth. Composition of the microbial community in the hibernaculum environment and the community on bat skin was superficially similar but differed in relative abundance of some bacterial taxa.
CONCLUSIONS: Our results are consistent with the hypothesis that Pd invasion leads to a shift in the skin microbiota of surviving bats and suggest the possibility that the microbiota plays a protective role for bats facing WNS. The detection of what appears to be enrichment of beneficial bacteria in the skin microbiota of persisting bats is a promising discovery for species re-establishment. Our findings highlight not only the potential value of management actions that might encourage transmission, growth, and establishment of beneficial bacteria on bats, and within hibernacula, but also the potential risks of such management actions.
However, patient self-evaluation indicated that the use of topical adhesive pads for 3 weeks may offer subjective improvement in crow's feet zone over a 2 hour period. Topical adhesive pads are safe to use and tolerable for most users Keyword: anti-aging. Keyword: cosmeticdermatology... Keyword: skintreatment. Keyword: wrinkles.
Indeed, disturbances of the stratum corneum have been noted in allergic diseases (eczema and food allergy), psoriasis, rosacea, acne vulgaris and with the skin aging process. The built environment, global biodiversity losses and declining nature relatedness are contributing to erosion of diversity at a micro-ecological level, including our own microbial habitats.
Here, we tested the effects of landcover, forest connectivity and infection by the chytrid fungus Batrachochytrium dendrobatidis (Bd) on amphibian skinbacterial diversity along deforestation gradients in Brazilian landscapes ... We found that forest corridors shaped composition of host skin microbiomes; high forest connectivity predicted greater similarity of skinbacterial communities among host populations ... Bd link but failed to find a significant effect of skinbacterial diversity reducing Bd infections.
Here, we report that the human skin odour profile is affected by malaria infection... the chemical composition and attractiveness to Anopheles coluzzii mosquitoes of skin odours from participants that were infected by Controlled Human Malaria Infection with Plasmodium falciparum ... We found a significant reduction in mosquito attraction to skin odour during infection for one experiment, but not in a second experiment, possibly ...
Abstract: The study aimed to develop evidence-based recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases. The task force comprised an expert group of specialists in rheumatology, dermatology and gastroenterology, and pharmacologists, patients and a regulator from ten countries. Four key topics regarding biosimilars were identified through a process of discussion and consensus.
Muscular and Skeletal Diseases (3), Dermatology (1) Rheumatic Diseases (1), more mentions
... use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists AbstractText: To ... and presence of ingredients represented in the North American Contact Dermatitis Group (NACDG) series were conducted using Wilcoxon rank sum tests... and botanicals for fragrances were derived from the American Contact Dermatitis Society's Contact Allergen Management Program database AbstractText: A total of ...
... the CSP+ , consistent with a more general role of the VMPFC in flexible value updating. Supporting a specific role in extinction retention, we further observed a cross-day association between VMPFC activation and skin conductance, a classic index of conditioned responses. Finally, cocaine users showed VMPFC abnormalities for both CSs, which, in the case of the CSD+ , correlated with craving.
Abstract: Human Leucocyte antigen (HLA) C*06:02 is identified as the allele associated with the highest risk for the development of the autoimmune skindisease psoriasis. However, the diversity and mode of peptide presentation by the HLA-C*06:02 molecule remains unclear. Here, we describe the endogenous peptide repertoire of approximately 3,000 sequences for HLA-C*06 ...
Dermatology (3), Immune System Diseases (1) Psoriasis (3), Skin Diseases (1), more mentions