DescriptorName: KidneyTransplantation... center, retrospective study of 594 adults with PCKD who had renaltransplants from 1994 to 2014... complications AbstractText: Five hundred sixty-five adults with PCKD received kidneytransplants (303 tx alone, 161 simultaneous, 27 pre... 16.3% of renaltransplant alone patients required nephrectomy at 10 years follow-up.
Kidney Disease (3) Polycystic Kidney Diseases (3), Thrombosis (2), Deep Vein Thrombosis (1), more mentions
AbstractText: Use of robotic surgery has increased in urological practice over the last decade... of patients who had undergone robotic-assisted or laparoscopic radical nephrectomy for renal mass at 416 US hospitals between January 2003 and September ... 95% CI, $473 to $1498) AbstractText: Among patients undergoing radical nephrectomy for renal mass between 2003 and 2015, the use of robotic-assisted ...
... to evaluate the influences of albumin 5% and balanced hydroxyethyl starch 6% (130/0.4) on renal function and kidney injury AbstractText: One-hundred urologic patients undergoing elective cystectomy were randomly assigned for this prospective, single-blinded, controlled study with two parallel groups to receive either albumin 5% or balanced hydroxyethyl starch ...
... estimated glomerular filtration rate (eGFR) within 2 years following radical nephrectomy for renal cell carcinoma AbstractText: A multi-center retrospective study was conducted ... term, a large proportion of patients recover to their preoperative renal function following radical nephrectomy for kidney tumors, and that recovery is more likely among those with ...
PURPOSE: Radical cystectomy (RC) is an inherently morbid procedure. The purpose of this review is to assess the timing and incidence of venous thromboembolism (VTE), review current guideline recommendations, and provide evidence for considering extended VTE prophylaxis among all patients undergoing RC.
MATERIALS AND METHODS: We conducted a PubMed search of available literature for RC and VTE, focusing on: incidence and timing, evidence supporting extended VTE prophylaxis (among RC and abdominal surgical oncology patients), current guideline recommendations, safety considerations, and direct oral anticoagulants. The search terms used included radical cystectomy, venous thromboembolism, prophylaxis, extended, and direct oral anticoagulants alone or in combination. Relevant articles were reviewed including original research, reviews and clinical guidelines. References from review articles and guidelines were also assessed to develop a narrative review.
RESULTS: The incidence of symptomatic VTE in short-term follow-up after RC is 3-11.6% of patients, of which more than 50% will occur after hospital discharge. Meta-analyses of clinical trials for patients undergoing major abdominal surgical oncology procedures suggests decreased risk of VTEs for patients receiving extended (4 weeks) VTE prophylaxis. Extended prophylaxis should be considered for all RC patients; although the relative risk of bleeding also increases, the overall net benefit of extended prophylaxis clearly favors use for at least 28 days post-operatively. Extra-renal eliminated prophylaxis agents are preferred given the risk of renal insufficiency in RC patients, with newer oral anticoagulants providing an alternative route of administration.
CONCLUSIONS: Patients undergoing RC are at high risk for VTE after hospital discharge. There is strong evidence that extended prophylaxis significantly decreases the risk of VTEs in surgical oncology patients. The use of extended prophylaxis post-RC has been poorly adopted, emphasizing the need for better adherence to current urology procedure specific guidelines, as extended prophylaxis for RC is the standard of care. Specific and typically rare circumstances may require case-by-case assessment.
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Of the other 8 reported prespecified secondary end points, including intraoperative complications, postoperative complications, plane of surgery, 30-day mortality, bladder dysfunction, and sexual dysfunction, none showed a statistically significant difference between groups AbstractText: Among patients with rectal adenocarcinoma suitable for curative resection, robotic-assisted laparoscopic surgery, as compared with ...
Oncology (5), Men's Health (2) Rectal Neoplasms (6), Adenocarcinoma (2), more mentions
... the recent developments in the applicability and clinical significance of epitope matching in kidneytransplantation... immunogenicity of mismatched donor epitopes and the applicability of HLA epitope matching in kidneytransplantation... clinicians to integrate epitope matching as an important parameter for donor selection in kidneytransplantation Keyword: acute rejection... Keyword: kidneytransplantation.
AbstractText: Cognition in ESRD may be improved by kidneytransplantation, but mechanisms are unclear... magnetic resonance imaging among patients with ESRD before and after kidneytransplantation AbstractText: Thirty-seven patients with ESRD scheduled for kidneytransplantation and 22 age-, sex-, and education-matched healthy subjects underwent ... Patients were imaged before and 1 and 6 months after kidneytransplantation.
AbstractText: Evidence that kidneytransplantation is associated with better survival compared to dialysis stems from ... relative risk of death in recipients of a deceased donor kidneytransplant after ≥10 years of dialysis treatment compared with waitlisted patients ... and did not derive survival benefit until 657 days after transplantation, despite receiving good-quality kidneys.
AbstractText: The role of surgery in metastatic bladder cancer (BCa) is unclear AbstractText: In this collaborative review article, we reviewed the contemporary literature on the surgical management of metastatic BCa and factors associated with outcomes to support the development of clinical guidelines as well as informed clinical decision-making AbstractText ...
Oncology (8) Urinary Bladder Neoplasms (4), Neoplasms (1), more mentions
... nonresident aliens have similar outcomes to US citizens after receiving kidneytransplants covered by Medicaid, a joint federal and state health insurance ... in the US Renal Data System who received their first kidneytransplant from 1990 to 2011 AbstractText: Citizenship status, categorized as US ... Policymakers should consider expanding coverage for kidneytransplantation in nonresident aliens, including undocumented immigrants, given the associated high-quality outcomes in these patients Keyword: Kidneytransplantation ...
Reply to Francesco Massari, Vincenzo Di Nunno, and Andrea Ardizzoni's Letter to the Editor re: Robert J. Motzer, Alain Ravaud, Jean-Jacques Patard, et al. Adjuvant Sunitinib for High-risk Renal Cell Carcinoma After Nephrectomy: Subgroup Analyses and Updated Overall Survival Results. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2017.09.008.
Re: Robert J. Motzer, Alain Ravaud, Jean-Jacques Patard, et al. Adjuvant Sunitinib for High-risk Renal Cell Carcinoma After Nephrectomy: Subgroup Analyses and Updated Overall Survival Results. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2017.09.008..
AbstractText: To evaluate the risk of post-transplantation malignancy in renaltransplant recipients exposed to pre-transplantation cyclophosphamide for treatment of glomerular ... study AbstractText: Tertiary academic medical center AbstractText: Six hundred adult renaltransplant recipients transplanted between 1993 and 2014; 54 patients were exposed to pre ... GN-CYC and PKD groups AbstractText: In our observational study, renaltransplant recipients exposed to pretransplantation cyclophosphamide appeared to have a higher risk of developing a malignancy compared with unexposed renaltransplant recipients ...
We then analyzed 1,245 consecutive non-renaltransplant patients who underwent outpatient cystourethroscopy, 610 of whom after protocol initiation. UTI rates and antibiotic use were analyzed for association with protocol change using Fisher's exact test AbstractText: Cultures had an overall 20% rate of resistance to fluoroquinolones (40% of cultures that grew Escherichia coli.
... between innovator tacrolimus and 2 generics in individuals with a kidney or liver transplant AbstractText: From December 2013 through October 2014, a prospective, replicate ... conducted at the University of Cincinnati in individuals with a kidney (n = 35) or liver transplant (n = 36... comparisons for AUC and Cmax in both individuals with a kidneytransplant and those with a liver transplant.
Abstract: Direct-acting antivirals have revolutionized the treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease, with implications for the timing of antiviral treatment among kidneytransplant candidates and for the use of HCV viremic donors... Keyword: kidneytransplantation.
Infectious Diseases (3), Immune System Diseases (1), Kidney Disease (1) Hepatitis C (2), Infections (1), Chronic Kidney Diseases (1), more mentions
... antibodies after the treatment of ABMR is unknown AbstractText: We included patients from the French multicenter RITUX ERAH study diagnosed with acute antibody-mediated rejection (ABMR) within the first year of renaltransplantation, with circulating anti-HLA DSAs and treated randomly by rituximab or placebo (and intravenous immunoglobulins, plasma exchange.