We therefore investigated the impact of [(18)F]-florbetaben (FBB)-PET on the diagnostic management of patients with suspected dementia that was still unclarified after [(18)F]-fluordeoxyglucose (FDG)-PET.All subjects were referred in-house with a suspected dementia syndrome due to neurodegenerative disease ... The highest impact was observed for distinguishing Alzheimer's dementia (AD) from fronto-temporal dementia (FTLD), where FBB-PET altered the most likely diagnosis in 41% of cases.FBB ... high additive value in establishing a final diagnosis in suspected dementia cases when prior investigations such as FDG-PET are inconclusive.
Neuroscience (7), Neurological and Central Nervous System Diseases (1) Dementia (7), Alzheimer Disease (1), Neurodegenerative Diseases (1), more mentions
... advent of biomarkers in clinical management and findings of molecular neuroimaging studies in the evaluation of patients with suspected dementia, the impact of functional neuroimaging has increased considerably these last years and has been integrated into many clinical guidelines in the field of dementia ... single PET brain perfusion and dopaminergic neurotransmission, 18F-fluorodeoxyglucose (18F-FDG) PET is used in advanced diagnosis procedures.
... primary care cohort suggests that the diagnostic accuracy of volumetric imaging markers may be similar in the dementia stage of AD, but may be inferior for cases with ... AbstractText: Evidence is still widely lacking on the use of imaging markers for early and differential diagnosis of AD dementia, and detection of prodromal AD in primary care ...
Diagnostic specificity of (18)F-FDGPET for diagnosing MSA, PSP and CBD was consistently shown to ... impairment (PD-MCI) being a prodromal stage of PD with dementia (PDD... Taken together, current literature underscores the utility of (18)F-FDGPET for diagnostic evaluation of parkinsonism and its promising role for ...
Neurological and Central Nervous System Diseases (2), Neuroscience (2) Parkinsonian Disorders (4), Parkinson Disease (2), Dementia (1), more mentions
... to study whether decreased gray matter volume predicted progression to dementia in the total sample, and stratified for baseline amyloid status.Dementia at follow-up occurred in 122 (44%) subjects over an ... pattern of decreased gray matter volume associated with progression to dementia was consistent for amyloid-positive and amyloid-negative subjects.
Our understanding of the clinical and radiological spectrum of CAA has continued to evolve, and there are new insights into ... context of ageing and intracerebral haemorrhage, as well as in Alzheimer's and other dementias... years, are now being reviewed to reflect these new wide-ranging clinical and radiological findings... Keyword: vascular dementia.
Neuroscience (3), Cardiovascular Diseases (2), Neurological and Central Nervous System Diseases (1) Alzheimer Disease (2), Cerebral Amyloid Angiopathy (2), Vascular Dementia (1), more mentions
... cerebral amyloid angiopathy is particularly important when planning to start or restart anticoagulation after an intracerebral hemorrhage. Given the lack of randomized trial data to guide management strategies, we discuss a heart-brain team approach that includes clinician-patient shared decision making for the use of pharmacologic and nonpharmacologic approaches to diminish stroke risk Keyword: Alzheimer’s dementia. Keyword: atrial fibrillation.
... tomography (Tc-HMPAO SPECT) and I ioflupane (I-FP-CIT also called DaTSCAN) imaging in a dementia diagnostic center were analyzed... lacks sensitivity; therefore, absence of the sign cannot be used to rule out dementia with Lewy bodies. A positive finding provides strong evidence to rule in dementia with Lewy bodies.
... is associated with white matter abnormalities or risk of clinical dementia in older people (n=126; mean age 86.4, SD: 7.7 ... histological lesions, increased fibrinogen was related to increased risk of dementia (odds ratio, 2.26; 95% confidence interval, 1.25-4.08; P=0.007 ... older people and that this may be related to clinical dementia risk, additional to standard MRI biomarkers Keyword: dementia.
Correction to: Effect of Long-Term Vascular Care on Progression of Cerebrovascular Lesions: Magnetic Resonance Imaging Substudy of the PreDIVA Trial (Prevention of Dementia by Intensive Vascular Care)..
AbstractText: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are nowadays recognized as spectrum disorders with a molecular link, the TAR DNA-binding protein 43 (TDP-43), rendering it a surrogate biomarker for these disorders AbstractText: We measured cerebrospinal fluid (CSF) levels of TDP-43, beta-amyloid ... Keyword: Frontotemporal dementia.
Neurological and Central Nervous System Diseases (8), Neuroscience (3) Amyotrophic Lateral Sclerosis (8), Frontotemporal Dementia (3), more mentions
... was to investigate the characteristic iron levels in the frontotemporal dementia subtypes using susceptibility-weighted imaging and report its association with behavioral profiles AbstractText: This prospective study included 46 patients with frontotemporal dementia (34 with behavioral variant frontotemporal dementia and 12 with primary progressive aphasia) and 34 age-matched ... a new biomarker in the diagnostic work-up of frontotemporal dementia and help distinguish frontotemporal dementia subtypes.
... reading frame 72 repeat expansion (C9orf72RE) AbstractText: Presymptomatic C9orf72RE carriers (n = 18) and first-degree family members without a pathogenic expansion (healthy controls [HC], n = 15) underwent a standardized protocol of neuropsychological tests, T1-weighted MRI, and diffusion tensor imaging within our cohort study of autosomal dominant frontotemporal dementia (FTD.
Neuroscience (2), Neurological and Central Nervous System Diseases (1) Amyotrophic Lateral Sclerosis (1), Frontotemporal Dementia (1), more mentions
... or management of NCBCs associated with AD, including depression, aggression or agitation, anxiety, apathy, psychosis, and sleep disorder. The authors identified dissociable neural substrates with multimodalimaging: depression implicates the lateral and superior prefrontal cortex; apathy and agitation implicate the dorsal anterior cingulate; psychosis implicates right lateralized frontal and medial temporal areas; and anxiety implicates mesial temporal regions... Keyword: Dementia.
This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed ... group of neurodegenerative diseases including Parkinson disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB.
Neurological and Central Nervous System Diseases (2), Neuroscience (1) Movement Disorders (2), Parkinsonian Disorders (2), Neurodegenerative Diseases (2), more mentions
Semantic dementia, including the semantic variant of primary progressive aphasia (svPPA), is ... Seven patients (five with svPPA and two with 'right' semantic dementia) and 12 healthy controls underwent positron emission tomography brain imaging with [(18)F]AV-1451 ... with those areas known to be most affected in semantic dementia... distribution of [(18)F]AV-1451 binding potential, separated semantic dementia from controls with 86% sensitivity and 100% specificity.[(18)F ...
... PET to assess amyloid-β plaque load and [F]fluorodeoxyglucose (FDG) PET to assess glucose metabolism.The behavioral variant of FTD (bvFTD ... The percentages of progressive nonfluent aphasia (PNFA) and semantic dementia (SD) were similar... Patterns of hypometabolism, determined by [F]FDGPET, were more specific to subtypes of FTLD and may help ...
Materials and Methods In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery ...