Although the INTACT sysytem is most commonly used as an alternative biopsy technique for its diagnostic capabilities, this study assessed its clinical role as a definitive therapeutic excisional modality in selected cases of benignbreastdisease. It proved valuable in the majority of cases with avoidance of surgery where it was traditionally indicated, (98/111, 88.3%) and as definitive fibroadenoma ...
Breast Diseases (1), Fibroadenoma (1), Carcinoma (1), more mentions
PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer.
METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined.
RESULTS: The screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% (n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed.
CONCLUSIONS: Screening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis.
Oncology (12) Neoplasms (10), Breast Neoplasms (2), Noninfiltrating Intraductal Carcinoma (1), more mentions
... we investigate and quantify NK cell marker CD56 and activating ligand MICA in breast tissue with benignbreastdisease AbstractText: Serial tissue sections from 88 subjects, 44 with benignbreastdisease (BBD) who remained cancer-free, and 44 with BBD who later developed cancer, were stained with ... Keyword: Benignbreastdisease.
Oncology (4) Breast Diseases (3), Neoplasms (3), Neoplastic Cell Transformation (1), more mentions
Conclusion The BI-RADS features of mammographic breast density, calcification morphology, mass margins at mammography and MR imaging, and nonmass enhancement at MR imaging have the potential to serve as imaging biomarkers of breast cancer recurrence risk. Further prospective studies involving larger patient cohorts are needed to validate these preliminary findings.
... core needle biopsy of a lesion yields a diagnosis of intraductalpapilloma with atypia, excision is generally recommended to rule out a ... For intraductalpapillomas without atypia, however, recommendations for excision versus observation are variable ... study are to evaluate the rate of concurrent malignancies for intraductalpapilloma diagnosed on core needle biopsy and to assess the long ...
Additionally, dense breasts and benignbreastdisease were significantly associated with positive ultrasonography after BIRADS 0 to 2 (all P values < .05) AbstractText: After negative mammography ... only be recommended for BIRADS 0 to 2 but not BIRADS 3, especially for women with dense breasts or benignbreastdisease Keyword: Breast cancer.
Oncology (3) Breast Diseases (2), Breast Neoplasms (2), Neoplasms (1), more mentions