transabdominal, transcervical) for prenataldiagnosis AbstractText: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (3 March 2017), ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP; 3 March 2017), and reference lists of retrieved studies AbstractText: All randomised trials comparing AC and CVS by either transabdominal or ...
... by a venal portal thrombosis.Outcome of intrahepatic portosystemic shunt diagnosedprenatally is good in the majority of cases... There is very few studies with only patients diagnosed in antenatal and it is a large series of cases. Outcome of intrahepatic portosystemic shunt diagnosedprenatally is good in the majority of cases.
OBJECTIVE: Isolated agenesis of the corpus callosum (ACC) on fetal ultrasound has a varied prognosis. Microarray and exome sequencing might aid in prenatal counseling.
METHOD: This study includes 25 fetuses with apparently isolated complete ACC (cACC) on ultrasound. All cases were offered SNP array. Complementary exome sequencing (ES) was offered postnatally in selected cases. Clinical physical and neurodevelopmental follow-up was collected.
RESULTS: Eighteen cases opted for SNP array testing, which detected a causal anomaly in 2/18(11.1%;95%CI2.0-31%). Among ongoing pregnancies without a causal anomaly on microarray, 30%(95%CI8.5-60) showed intellectual disability (ID). Postnatal MRI and physical examination often (64%;95%CI38-85 and 64%;95%CI38-85, respectively) revealed additional physical anomalies in cases without a causal anomaly on microarray. Two cases appeared truly isolated after birth. Postnatal sequencing in four of sixteen cases without a causal anomaly on microarray but with ID and/or additional postnatal physical anomalies, revealed two single gene disorders. Therefore, the estimated diagnostic yield of ES in chromosomally normal cACC fetuses is between 2/4(50%;95%CI11-89) and 2/16(13.3%;95%CI2.4-36).
CONCLUSION: In accordance with current guidelines, we conclude that microarray should be offered in case of isolated cACC on ultrasound. ES is likely to be informative for prenatal counseling and should be offered if microarray is normal.
Non-invasive prenataldiagnostics (NIPD) of monogenic diseases therefore relies on parental haplotyping and statistical assessment of inherited alleles ... be implemented in any clinic to provide families carrying a severe monogenic disease with a prenataldiagnostic test based on a simple blood draw Keyword: CAH... Keyword: non-invasive prenataldiagnosis.
... pregnancy (OR 0.24; 95% CI 0.90-0.65) were significantly more likely to make an informed choice AbstractText: The findings highlight the challenges of ensuring informed choice in routine prenatalcare where NIPT is not discussed at multiple points, less time is available for counselling and written consent is not required.
... as an alternative service delivery model for women with a positive prenatalscreening result AbstractText: Women were recruited from a prenatal genetics service and ... and satisfaction following individual and group genetic counseling for a positive prenatalscreen... individual genetic counseling appears acceptable to women in a high-risk prenatalscreening population.
Re: Association between inadequate antenatalcare utilisation and severe perinatal and maternal morbidity: an analysis in the PreCARE cohort: Antenatalcare utilisation and severe perinatal/maternal morbidity in PreCARE cohort..
Bilateral tubal ectopicpregnancies are a rare subset of ectopicpregnancy that can pose a diagnostic dilemma for clinicians ... no single diagnostic feature to help clinicians delineate bilateral tubal ectopicpregnancies from other types of ectopicpregnancy prior to passing the discriminatory zone (such as heterotopic pregnancy ... implications of this case suggest that diagnosis of bilateral tubal ectopicpregnancies requires clinicians to have a high level of suspicion in any pregnant female with a suspected or known ectopicpregnancy who presents with pelvic pain regardless of prior diagnosis or ...
... CMV) infection AbstractText: Women were screened with CMV serology during prenatalcare before 20 weeks of gestation and followed for at least ... 2:1 to either a brief behavioral intervention during their prenatalcare visit or to standard care (a brochure... for all) AbstractText: A brief behavioral intervention delivered in the prenatalcare setting was modestly effective at changing behaviors related to CMV ...
The enthusiasm of researchers, prospective parents, and the biomedical industry should be balanced with a measured approach. Optimal counseling for a particular screening or prenataldiagnostic test to be chosen, or declined, involves a comprehensive understanding of the available tests, the conditions to be screened for, time, and good communication skills. This article is protected by copyright.
Abstract: Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopicpregnancy in women. Despite these disease associations, which parallel those of Chlamydia trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular ...
Pelvic inflammatory disease (PID) is an important cause of infertility and ectopicpregnancy, and Chlamydia trachomatis and Neisseria gonorrhoeae are recognized microbial causes. Emerging data demonstrate an association between M. genitalium and PID, and limited data suggest associations with infertility and preterm birth, yet the attributable risk for female genital tract infections remains to be defined.
Women's Health (1) Pelvic Inflammatory Disease (5), Infertility (4), Premature Birth (3), more mentions
... million commercially insured and 8 million Medicaid enrollees annually to estimate prenatalcare and follow-up testing among women who had stillbirths between January ... women with stillbirths, we estimated the proportions of women who received prenatalcare and prenatal syphilis testing within 280 days before stillbirth, and testing at the ...
Syphilis (12), Infections (1), Congenital Syphilis (1), more mentions
Among medically low-risk women, the model demonstrated effective care variations including 82% attendance at prenatal education classes, 99% receiving midwifery-led prenatalcare, and 84% with midwifery- attended birth. Patient preferences were adhered to with 83% of women achieving birth at their preferred site of birth, and 95% of women using their preferred infant feeding method.
Who receives care and when: queuing strategies and antenatalcare to groups of mothers. Who provides care: lay health workers for caring for people with hypertension, lay health workers to deliver care for mothers and children or infectious diseases, lay health workers to deliver community-based neonatal care packages, midlevel health professionals for abortion care, social support to pregnant women ...
Immune System Diseases (8), Cardiovascular Diseases (1), Infectious Diseases (1) Pneumonia (1), Communicable Diseases (1), Hypertension (1), more mentions