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Immunology Science and Genetics
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Your search returned 15 results
from the time period: last 30 days.
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The Lancet. Infectious diseases 
... and characterised these strains for their antimicrobial susceptibility, multilocus sequence types, and genetic relatedness using VITEK-2 compact system, multilocus sequence typing, and whole genome ... a human neutrophil assay and Galleria mellonella model and to establish the genetic basis of their hypervirulence phenotype AbstractText: All five patients had undergone surgery ...
Infectious Diseases (2)
Infections (2), Pneumonia (1), Community-Acquired Infections (1), more mentions
Genome biology 
AbstractText: Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4(+) T cells ... Hi-C. By integrating promoter capture Hi-C data with genetic associations for five autoimmune diseases, we prioritised 245 candidate genes with a median distance ... cell state-specific functional effects, with achievable sample sizes Keyword: Autoimmune disease.
Immune System Diseases (4)
Autoimmune Diseases (4), more mentions
Nature reviews. Endocrinology 
Abstract: Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a reduced genetic load, a less intensive autoimmune process and a mild metabolic decompensation at onset compared with ... LADA is characterized by genetic, phenotypic and humoral heterogeneity, encompassing different degrees of insulin resistance and autoimmunity; this heterogeneity is probably a result of different pathological mechanisms ...
Endocrine Disorders (13), Immune System Diseases (7)
Autoimmune Diabetes (6), Diabetes Mellitus, Type 1 (1), Diabetes Mellitus, Type 2 (1), more mentions
Journal of human genetics 
We identified the pathogen lineage in 686 Thai TB cases and GWAS stratified by both infected pathogen lineage information and age at onset revealed a genome-wide ... The results suggested that host genetic risk in TB is depended upon the pathogen genetic background and demonstrate the importance of analyzing the interaction between host and pathogen genomes in TB.Journal of Human Genetics advance online publication, 7 September 2017; doi:10.1038/jhg.2017.82 ...
Cardiovascular Diseases (3)
Tuberculosis (3), more mentions
Science (New York, N.Y.) 
... in myeloid function, although the mechanism of myeloid cell-mediated immune surveillance remains unclear... features in Aspergillus fumigatus conidia, the most prevalent human mold pathogen... Genetic and pharmacologic studies indicate that AfBIR1 expression and activity underlie ... Immune surveillance exploits a fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung ...
Aspergillosis (1), more mentions
... type 16 (HPV16) infections become undetectable within 1-2 years, persistent HPV16 causes half of all cervical cancers. We used a novel HPV whole-genome sequencing technique to evaluate an exceptionally large collection of 5,570 HPV16-infected case-control samples to determine whether viral genetic variation influences risk of cervical precancer and cancer... Keyword: HPV epidemiology. Keyword: HPV genomics.
Oncology (1)
Neoplasms (1), Infections (1), more mentions
Additionally, using a reverse genetic screen, we identify the kinase SID-3 as a new ... STA-1, participates in the transcriptional regulatory network of the immune response... these results illustrate the complex evolutionary trajectory displayed by innate immune signaling pathways across metazoan organisms.IMPORTANCE Since innate immunity was discovered, a diversity of pathways has arisen as powerful ...
Immune System Diseases (9)
Infections (8), more mentions
American journal of human genetics 
Fully realizing the clinical potential of genetics requires that we accurately infer pathogenicity even for rare or private variation ... developed, but they can identify only a small fraction of pathogenic variants with the high confidence that is required in the ... clinical knowledge for the development of "lookup tables" of accurate pathogenicity predictions.
Frontiers in psychiatry 
... only in both nutritive and digestive activities but also in immunological processes... both environmental-diet, exposition to antibiotics, and infections-and host-genetic factors have a strong influence on gut microbiome, modulating the ... and in the etiology of the depressive syndrome, including nutritional, immunological, and energy homeostasis approaches Keyword: depression.
Infectious Diseases (1)
Depressive Disorder (5), Infections (1), more mentions
The Journal of cell biology 
Abstract: A propensity for rewiring genetic and epigenetic regulatory networks, thus enabling sustained cell proliferation, suppression of apoptosis, and the ability to evade the immune system, is vital to cancer cell propagation ... H3K9 methyltransferase SETDB1 as a novel, negative regulator of innate immunity... regulatory axis that cancer cells can exploit to circumvent the immune system.
Oncology (4)
Acute Myeloid Leukemia (2), Neoplasms (2), more mentions
Nature genetics 
... method to obtain robust estimates of the impact of local sequence features on mutation parameters and used these estimates to create a framework for measuring constraint at STRs by comparing observed versus expected mutation rates. Constraint scores identified known pathogenic variants with early-onset effects. Our metric will provide a valuable tool for prioritizing pathogenic STRs in medical genetics studies.
Proceedings of the National Academy of Sciences of the United States of America 
... The ability of root cells to distinguish mutualistic microbes from pathogens is crucial for plants that allow symbiotic microorganisms to infect ... Mtlyr4 mutants were also more susceptible to fungal and bacterial pathogens, while infection and colonization by rhizobia and arbuscular mycorrhizal fungi ... This establishes a foundation for genetic and biochemical dissection of the perception and the downstream responses ...
Infections (1), more mentions
Nature genetics 
We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through ... new regulators of processes central to IBD but also provides the integrated circuits of genetic, molecular, and clinical traits that can be directly queried to interrogate and refine the ...
Inflammatory Bowel Diseases (2), more mentions
PLoS pathogens 
This flow of genetic information results in a metabolic shift toward aerobic glycolysis in the surrounding non-infected cells... This exosome-based crosstalk provides viruses with a mechanism for non-infectious transfer of genetic material without production of new viral particles, which might expose them to the immune system. We suggest that viruses and cancer cells use this mechanism to ...
Oncology (2), Infectious Diseases (1)
Kaposi Sarcoma (2), Neoplasms (2), Infections (1), more mentions
Journal of virology 
... the capacity to integrate into telomeres, the essential capping structures of chromosomes that play roles in cancer and ageing. About 1% of people worldwide are carriers of chromosomally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait... These discoveries represent potentially important considerations in immune-compromised patients, in particular in organ transplantation and in stem cell therapy.
Oncology (1)
Neoplasms (1), more mentions