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Immunology Science and Genetics
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Your search returned 47 results
from the time period: last 30 days.
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Nature communications 
Abstract: Red Queen host-parasite co-evolution can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Queen arms race) or results in a balanced polymorphism (Red Queen dynamics) and long-term preservation of genetic variation (trans-species polymorphism. These two Red Queen processes are opposite extremes of the co-evolutionary spectrum.
AbstractText: Helicobacter pylori is remarkable for its genetic variation. Yet little isknown about its genetic changes during early stages of human infection, as the bacteria ... Functional effects of genetic changes observed in H pylori strains during human infection were ... differentvolunteers to obtain a robust estimate of the frequency of genetic and epigenetic changes inthe absence of inter-strain recombination... Keyword: pathogen.
Vaccines (3), Oncology (1)
Infections (6), Neoplasms (1), more mentions
Abstract: Background -The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown... A lower clinical risk factor burden was associated with later AF onset after adjusting for genetic predisposition (P value <0.001... Keyword: epidemiology. Keyword: genetics. Keyword: lifetime risk. Keyword: polygenic risk.
Cardiovascular Diseases (3), Endocrine Disorders (1)
Atrial Fibrillation (3), Heart Failure (1), Myocardial Infarction (1), more mentions
Nature communications 
Abstract: Genetic factors and mechanisms underlying food allergy are largely unknown... food demonstrates that association of the HLA locus is peanut allergy-specific whereas the other four loci increase the risk for any food allergy ... All identified loci are involved in immunological regulation or epithelial barrier function, emphasizing the role of both mechanisms in food allergy ...
Food Hypersensitivity (5), Peanut Hypersensitivity (1), more mentions
Nature genetics 
Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology..
Nature ecology & evolution 
Abstract: Armillaria species are both devastating forest pathogens and some of the largest terrestrial organisms on Earth... fungi revealed a significant genome expansion in Armillaria, affecting several pathogenicity-related genes, lignocellulose-degrading enzymes and lineage-specific genes expressed ... results suggest that the evolution of the unique dispersal and pathogenicity mechanisms of Armillaria might have drawn upon ancestral genetic toolkits for wood-decay, morphogenesis and complex multicellularity ...
Scientific reports 
Abstract: Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations... The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses.
Dengue (3), Infections (1), more mentions
BMJ (Clinical research ed.) 
DescriptorName: Genetic Predisposition to Disease. DescriptorName: Genetic Variation... with risk of cancer.Design Mendelian randomisation study.Setting Large genetic epidemiology networks (the Genetic Associations and Mechanisms in Oncology (GAME-ON), the Genetic and Epidemiology of Colorectal Cancer Consortium (GECCO), and the Prostate Cancer Association ... Specifically, the odds ratios per 25 nmol/L increase in genetically determined 25(OH)D concentrations were 0.92 (95% confidence interval ...
Oncology (21)
Neoplasms (8), Colorectal Neoplasms (4), Prostatic Neoplasms (4), more mentions
Journal of neurology, neurosurgery, and psychiatry 
... review, we describe and compare the clinical features associated with pathogenic LGI1 and CASPR2 antibodies, illustrate emerging laboratory techniques for antibody determination and describe the immunological mechanisms that may mediate antibody-induced pathology ... Finally, data have suggested that CASPR2 and LGI1 modulation via genetic or autoimmune mechanisms may share common intermediate molecules.
Immune System Diseases (2), Neurological and Central Nervous System Diseases (1), Pain Management (1)
Isaacs Syndrome (1), Neuralgia (1), Primary Dysautonomias (1), more mentions
Nature communications 
Abstract: While constantly rising, the prevalence of allergies is globally one of the highest among chronic diseases... Hence, therapeutic gene networks monitoring disease-associated cytokines coupled with in situ production, secretion and systemic delivery of immunomodulatory biologics may foster advances in the treatment of allergies.
Allergy (2), more mentions
Trends in ecology & evolution 
... smaller genomes, and fewer genes, than their nonpathogenic, or less pathogenic relatives... We focus on the population genetic processes that might lead to reductive genome evolution, and show how several of these could be connected to pathogenicity ... evidence for most of the processes having acted in bacterial pathogens, including several different modes of genome reduction acting in the ...
American journal of human genetics 
Abstract: Although genetic correlations between complex traits provide valuable insights into epidemiological and etiological studies, a precise quantification of which genomic regions ... Notably, we find 6 genomic regions that contribute to the genetic correlation of 10 pairs of traits that show negligible genome-wide correlation, further showcasing the power of local genetic correlation analyses ...
Nature reviews. Microbiology 
Therefore, co-infection provides reciprocal advantages to both pathogens. In this Review, we describe the epidemiological associations between the two pathogens, selected interactions of each pathogen with the host and our current understanding of how they ... and consequences of HIV-1 depletion of T cells on immune responses to M. tuberculosis.
Immune System Diseases (10), Cardiovascular Diseases (6)
Tuberculosis (6), Coinfections (4), Infections (3), more mentions
Molecular ecology 
... are important mediators of plant defense responses to diverse aboveground pathogen and insect challengers... ISR), systemic susceptibility (ISS), or neither against the bacterial foliar pathogen Pseudomonas syringae pv... CH267, which induces ISS against bacterial pathogens, tips the JA/SA tradeoff towards JA-dependent defenses against ... cost of a subset of SA-mediated defenses against bacterial pathogens.
Nature microbiology 
... albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen... CRISPR-Cas9-based 'gene drive array' platform to facilitate efficient genetic analysis in C. albicans... This platform transforms our ability to perform genetic interaction analysis in C. albicans and is readily extended to other fungal pathogens ...
Infections (1), more mentions
Genome medicine 
... exome sequencing, has become a routine clinical procedure to identify pathogenic variants responsible for a patient's phenotype... We investigated the capacity of this NGM platform to identify pathogenic SV in a series of patients diagnosed with Duchenne muscular ... AbstractText: We showed the ability of NGM technology to detect pathogenic structural variants otherwise missed by PCR-based techniques or chromosomal ...
Muscular and Skeletal Diseases (2)
Duchenne Muscular Dystrophy (2), more mentions
Nature ecology & evolution 
... original diversity, and generation of new diversity as aneuploidy-prone chromosomes tolerate higher mutation rates. Our results reveal high aneuploidy turnover and haplotype selection as a unique evolutionary adaptation mechanism that L. donovani uses to preserve genetic diversity under strong selection. This unexplored process may function in other human diseases, including fungal infection and cancer, and stimulate innovative treatment options.
Oncology (1)
Aneuploidy (3), Leishmaniasis (1), Infections (1), more mentions
Nature genetics 
... coexist in the same individuals, partly because of a shared genetic origin... enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity... genes CpG methylation was found to influence transcription independently of genetic effects... hay fever and eczema partly coexist because they share many genetic risk variants that dysregulate the expression of immune-related genes.
Dermatology (1)
Asthma (3), Seasonal Allergic Rhinitis (3), Eczema (3), more mentions
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 
... investigate the prevalence of PD-L1 and the characteristics of immune environment in this disease AbstractText: A total of 99 archival ... a low mutational load with a complex mutational landscape of genetic variations more frequently associated with the p53/DNA repair and ... samples, either in the tumor cells (TC) or the infiltrating immune cells.
Oncology (5)
Neoplasms (7), Mesothelioma (3), more mentions
Nature reviews. Neuroscience 
... early neurodevelopmental events have been implicated in pathogenesis, initially by epidemiological and circumstantial data but more recently by brain-specific molecular and genetic findings ... Review revisits the neurodevelopmental model of schizophrenia from a current genetics perspective, delineating the complex genetic basis of the disorder and highlighting gene expression and epigenetic ...
Neuroscience (6)
Schizophrenia (6), more mentions
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