DescriptorName: Angioedema... Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam... propensity score-matching was conducted and hazard ratios computed for angioedema events by per-protocol and intent-to-treat analyses... suggest that levetiracetam has the same or lower risk for angioedema than phenytoin, which does not currently carry a labeled warning for angioedema ...
Neurological and Central Nervous System Diseases (1) Angioedema (10), Epilepsy (1), Adverse Drug Reaction (1), more mentions
Cleaved high-molecular weight kininogen (cHK) in plasma is a biomarker for bradykinin formation. We developed an immuno-assay to detect cHK in plasma. cHK plasma levels are increased in asymptomatic C1-INH-HAE patients, and increase further during angioedema attacks..
Hereditaryangioedema (HAE) is an autosomal-dominant disorder owing to mutations in the C1 inhibitor gene... Angioedema can be peripheral, abdominal, or laryngeal. The typical duration of episodes is 3 days. Therapies include C1 inhibitor replacement for prophylaxis or acute therapy, whereas inhibition of kallikrein or blockade at the bradykinin receptor level can interrupt acute episodes of swelling.
AbstractText: Severe attacks of hereditaryangioedema (HAE) are debilitating and potentially life threatening, and can increase anxiety and the use of medical resources AbstractText: This post hoc assessment evaluated recombinant human C1 esterase inhibitor (rhC1-INH) used to treat acute severe HAE attacks AbstractText: In a double-blind, randomized-controlled ...
... quality of life (HR-QoL) is impaired in patients with hereditaryangioedema (HAE) but has notyet been satisfactorily described AbstractText: To study ... RAND Corporation Short Form 36 (RAND-36), the disease-specific Angioedema Quality of Life instrument (AE-QoL), the recently introduced Angioedema Activity Score (AAS) form, and questionnaires on sick leave and ...
Angioedema (2), Hereditary Angioedema (2), Depressive Disorder (2), more mentions
AbstractText: Hereditaryangioedema (HAE) with normal C1-INH (HAEnCI) may be linked to specific mutations in the coagulation factor 12 (FXII ... Two women died by asphyxiation due to a tongue swelling AbstractText: Hereditaryangioedema with a mutation in the PLG gene is a novel type of HAE... Keyword: hereditaryangioedema.
AbstractText: Hereditaryangioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen ... They had a familial history of angioedema and normal C1 inhibitor (C1-INH) levels, leading to the diagnosis of HAE with normal C1-INH (HAEnC1-INH) or ...
Abstract: Several treatment modalities have become available for management of acute hereditaryangioedema (HAE) attacks in the last 15 years... Keyword: Hereditaryangioedema. Keyword: Icatibant. Keyword: Treatment of HAE. Keyword: rh C1-INH.
Abstract: This article discusses orphan diseases, their prevalence, legislative incentives to encourage development of therapies, and the impact of treatment on health care payment systems. Specifically, the cost burden of hereditaryangioedema on patients, health care systems, and society is reviewed... Keyword: Hereditaryangioedema. Keyword: Orphan disease. Keyword: Pharmacoeconomics. Keyword: Treatment.
... progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies... However, hereditaryangioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society ... the emerging therapeutic options for the treatment of HAE Keyword: Angioedema.
BACKGROUND: In early 2015, clinicians throughout Zambia noted a range of unpredictable adverse events after the administration of propofol, including urticaria, bronchospasm, profound hypotension, and most predictably an inadequate depth of anesthesia. Suspecting that the propofol itself may have been substandard, samples were procured and sent for testing.
METHODS: Three vials from 2 different batches were analyzed using gas chromatography-mass spectrometry methods at the John L. Holmes Mass Spectrometry Facility.
RESULTS: Laboratory gas chromatography-mass spectrometry analysis determined that, although all vials contained propofol, its concentration differed between samples and in all cases was well below the stated quantity. Two vials from 1 batch contained only 44% ± 11% and 54% ± 12% of the stated quantity, whereas the third vial from a second batch contained only 57% ± 9%. The analysis found that there were no hexane-soluble impurities in the samples.
CONCLUSIONS: None of the analyzed vials contained the stated amount of propofol; however, our analysis did not detect additional contaminants that would explain the adverse events reported by clinicians. Our results confirm the presence of substandard propofol in Zambia; however, anecdotal accounts of substandard anesthetic medicines in other countries abound and warrant further investigation to provide estimates of the prevalence and scope of this global problem.
Urticaria (2), Bronchial Spasm (2), Hypotension (2), more mentions
Urticaria commonly presents with intensely pruritic wheals, sometimes with edema of the subcutaneous or interstitial tissue. It has a lifetime prevalence of about 20%. Although often self-limited and benign, it can cause significant discomfort, continue for months to years, and uncommonly represent a serious systemic disease or life-threatening allergic reaction. Urticaria is caused by immunoglobulin E- and non-immunoglobulin E-mediated release of histamine and other inflammatory mediators from mast cells and basophils. Diagnosis is made clinically; anaphylaxis must be ruled out. Chronic urticaria is idiopathic in 80% to 90% of cases. Only a limited nonspecific laboratory workup should be considered unless elements of the history or physical examination suggest specific underlying conditions. The mainstay of treatment is avoidance of triggers, if identified. The first-line pharmacotherapy is second-generation H1 antihistamines, which can be titrated to greater than standard doses. First-generation H1 antihistamines, H2 antihistamines, leukotriene receptor antagonists, high-potency antihistamines, and brief corticosteroid bursts may be used as adjunctive treatment. In refractory chronic urticaria, patients can be referred to subspecialists for additional treatments, such as omalizumab or cyclosporine. More than one-half of patients with chronic urticaria will have resolution or improvement of symptoms within a year.
BACKGROUND: An altered gut microbiota composition has recently been linked to some types of allergies.
OBJECTIVE: To compare the relative amounts of Akkermansia muciniphila, Clostridium leptum, Faecalibacterium prausnitzii, and Enterobacteriaceae as members of gut microbiota among patients with chronic urticaria (CU) and healthy controls.
METHODS: A total of 20 patients with CU and 20 healthy individuals matched by age and sex participated in the study. Fresh fecal samples were collected, and DNA extracted from stool samples was analyzed by real-time polymerase chain reaction for the qualitative and quantitative assays of the so-called bacteria.
RESULTS: The frequencies of A muciniphila, C leptum, and F prausnitzii in healthy controls' stool samples were significantly more than those of patients with CU (P < .001, P < .01, and P < .05, respectively), whereas the Enterobacteriaceae family was detected in all patients and healthy controls' stool samples. The relative amounts of A muciniphila in healthy control positive samples were significantly higher than those of samples from patients with CU (P < .001). Furthermore, there was a corresponding increase of relative amounts of C leptum and F prausnitzii in healthy control positive samples compared with those of patients with CU (P = .09 and P = .08, respectively). The mean of the relative amounts of Enterobacteriaceae family in the stool samples from patients with CU was more than that of healthy controls; however, the difference was nearly significant (P = .12).
CONCLUSION: The results reveal a change of frequency and relative amounts of A muciniphila, C leptum, and F prausnitzii in patients with CU compared with healthy controls. This is the first study, to our knowledge, to show the change of microbiota composition in patients with CU.
Angioedema is frequently categorized into histamine- or bradykinin-mediated disease... Histaminergic angioedema is the most frequent cause of angioedema... It is further classified into angioedema presenting with or without urticaria. Some patients with acute angioedema may have disease that becomes chronic... basophils are central to the underlying pathophysiology of histamine-mediated angioedema.
... inhibitors are the most common classes of drugs that cause angioedema. Drug-induced angioedema is known to occur via mechanisms mediated by histamine, bradykinin ... Nonallergic angioedema occurs in patients with genetic variants that affect metabolism or ... The mainstay in treatment of nonallergic drug-induced angioedema is cessation of the offending agents.
Infectious Diseases (2), Muscular and Skeletal Diseases (1) Angioedema (5), more mentions