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Allergen Immunotherapy
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Your search returned 23 results
from the time period: last 30 days.
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The Journal of allergy and clinical immunology 
AbstractText: Three years treatment with either sublingual or subcutaneous allergen immunotherapy has been shown to be effective and to induce long ... immune response displayed significant and coordinate alterations during 2 years allergen desensitization, followed by reversal at 3 years, reflecting a lack of a durable immunological effect ... partially inhibited one year following discontinuation AbstractText: Two years of allergen immunotherapy were effective but insufficient for long-term tolerance.
Allergy (1), more mentions
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the US and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries - such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines. Customs and traditions, such as diet and infant feeding practices, also differ between Asian populations. Hence, there are unique challenges in adapting guidelines on early allergenic food introduction to the Asian setting. In this paper, we review the evidence and discuss the possible approaches to guide the timely introduction of allergenic food in high-risk infants in Asia. This article is protected by copyright. All rights reserved.
Food Hypersensitivity (5), Peanut Hypersensitivity (2), Wheat Hypersensitivity (1), more mentions
Allergy and asthma proceedings
AbstractText: Studies on real-life adherence to subcutaneous allergen immunotherapy (SCIT) for respiratory allergy are scarce. The aim of this study was to evaluate adherence to SCIT AbstractText: The patients prescribed SCIT for allergic rhinitis and/or asthma in 2009-2011 were contacted in 2014 and asked whether they completed at least the 3 years of SCIT and/or whether ...
Asthma (2), Allergy (1), Rhinitis (1), more mentions
Aggressive behavior 
... we suggest that frequent and repetitive exposure to hate speech leads to desensitization to this form of verbal violence and subsequently to lower evaluations of ... After desensitization training individuals were less sensitive to hate speech and more prejudiced toward ... elucidate the effects of exposure to hate speech on outgroup prejudice Keyword: desensitization.
Oncotarget
Loss of immunosurveillance is a major cause of cancer progression. Here, we demonstrate that gelsolin, a constituent of ejaculate, induces apoptosis of activated lymphocytes in prostate cancer. Gelsolin was highly expressed in prostate cancer cells, and was associated with tumor progression, recurrence, metastasis, and poor prognosis. In vitro, secreted gelsolin inactivated CD4(+) T cells by binding to CD37, and induced apoptosis of activated CD8(+) T lymphocytes by binding to Fas ligand during cell contact dependent on major histocompatibility complex I. Moreover, secreted gelsolin bound to sortilin, which in turn bound to Wiskott-Aldrich syndrome protein family member 3, thereby enhancing the endocytosis and intracellular transport of essential lipids needed to facilitate tumor growth and expansion. Under normal conditions, gelsolin is a seemingly harmless protein that prevents immune responses in female recipients. In disease states, however, this protein can inhibit immunosurveillance and promote cancer progression.
Oncology (7)
Neoplasms (5), Prostatic Neoplasms (4), Wiskott-Aldrich Syndrome (1), more mentions
Cancer letters
Multidrug resistance is one major barrier to successful chemotherapy. Although several studies have attempted to overcome resistance of cancer cells to anti-cancer drugs, key determinants of resistance remain largely unknown. The objective of this study was to investigate whether microRNAs might play a role in the acquisition of resistance. Human colorectal cancer HCT-116 cell lines were transduced with a lentivirus library containing 578 precursor microRNAs (miRNAs) to establish cell lines resistant to 5-fluorouracil (5-FU). Specific miRNAs were identified from four different resistant clones and a miR-195-expressing resistant clone (HCT-116_lenti-miR-195) was further investigated. The HCT-116_lenti-miR-195 cells showed resistant phenotype. These cells grew faster after 5-FU treatment compared to control cells (HCT-116_lenti-control). Check point kinase 1 (CHK1) and G2 check point kinase WEE1 were found to be direct targets of miR-195. Downregulation of miR-195 sensitized HCT-116 cells after 5-FU treatment. Our results demonstrate that miR-195 can promote acquisition of drug resistance to 5-FU.
Oncology (5)
Neoplasms (3), Colorectal Neoplasms (1), Colonic Neoplasms (1), more mentions
Immunology and allergy clinics of North America
Food allergy results from a loss of oral tolerance toward ingested antigens. Oral immunotherapy is thought to initiate desensitization through interaction of an allergen with mucosal dendritic cells that initiate downstream immune system modulation through regulatory T cells and effector T cells Keyword: CD4(+) T cells. Keyword: Dendritic cells. Keyword: Food allergy.
Food Hypersensitivity (2), more mentions
Current opinion in allergy and clinical immunology
Volumes are however small or highly diluted through reflex tearing AbstractText: Secretions reflect the local inflammatory activity and provide valuable information about the immunological reaction to allergens at the target organ. There is increasing evidence of the potential clinical role of their analysis, for diagnosis, and monitoring of allergic rhino-conjunctivitis.
Conjunctivitis (1), more mentions
Critical care medicine
AbstractText: Alarm fatigue is a widely recognized safety and quality problem where exposure to high rates of clinical alarms results in desensitization leading to dismissal of or slowed response to alarms. Nonactionable alarms are thought to be especially problematic. Despite these concerns, the number of clinical alarm signals has been increasing as an everincreasing number of medical technologies are added ...
The journal of allergy and clinical immunology. In practice 
AbstractText: Peanut oral immunotherapy, using a variety of approaches, has been previously shown to induce desensitization in peanut-allergic subjects, but no products have been approved for clinical use by regulatory agencies AbstractText: We performed the first phase 2 multicentered study to assess the safety and efficacy of ... Keyword: Desensitization.
Peanut Hypersensitivity (2), Food Hypersensitivity (1), more mentions
Immunology and allergy clinics of North America
Although oral immunotherapy (OIT) is effective at inducing desensitization, the temporary nature of this effect and high rates of adverse reactions have highlighted a need for novel strategies to improve tolerance induction and safety. One such strategy is the use of an adjuvant together with food immunotherapy to either suppress allergic reactions and/or modulate the underlying allergic immune response.
Food Hypersensitivity (2), Allergy (1), more mentions
Liver international : official journal of the International Association for the Study of the Liver
Before desensitization, the median isoagglutinin titre was 1:8 (range, 1:2-1:64... simplified protocol using rituximab and IVIG for ABO-I LDLT was safe and effective in achieving sufficient desensitization and comparable outcomes in patients with the titre no higher than 1:64 Keyword: ABO incompatibility. Keyword: desensitization.
Pathologic Constriction (1), Infections (1), more mentions
European journal of pain (London, England)
... in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features.
Pain Management (1)
Chronic Pain (6), Neuralgia (1), Visceral Pain (1), more mentions
Cell reports 
Molecular modeling and simulation experiments provide insight into oxytocin-TRPV1 interactions, which resemble DkTx. Together, our findings suggest the existence of endogenous regulatory pathways that modulate nociception via direct action of oxytocin on TRPV1, implying its analgesic effect via channel desensitization Keyword: MD simulations. Keyword: TRPV1 ion channel. Keyword: molecular dynamics simulations.
Allergy and asthma proceedings
... tool in evaluating HSRs to biologics; however, its predictive value depends on the type of reaction and the monoclonal antibody. Desensitization is a new approach to safely reintroduce biologics when they are first-line therapies, and it is available for immediate and delayed reactions. Research is needed to further understand the mechanisms of reactions to monoclonal antibodies and their management.
Clinical transplantation
Abstract: The endeavor to study desensitization in kidney transplantation hasn't been matched by an effort to investigate strategies to prevent sensitization. In this study (NCT02437422), we investigated the safety, impact on sensitization and pharmacokinetics of SANGUINATE (SG), a hemoglobin-based oxygen carrier, as a potential alternative to packed red blood cells (PRBC) in transplant candidates with end-stage renal disease ...
Kidney Disease (2)
Chronic Kidney Failure (5), Myocardial Infarction (1), more mentions
Drug safety
The most common override reasons in the inpatient and outpatient settings were 'administer per desensitization protocol' (n = 64, 31.7%) and 'patient does not have this allergy' (n = 7, 63.6%), respectively. No harm was associated with overrides in either setting, particularly because many medications were not administered AbstractText: Overrides of 'definite' anaphylaxis DAI alerts were common and often appropriate.
Anaphylaxis (6), Allergy (3), Drug Hypersensitivity (1), more mentions
Oncotarget
Methylation by protein arginine methyl transferase 1 (PRMT1) desensitizes the mitochondrial Ca(2+) uptake machinery and reduces mitochondrial Ca(2+) accumulation in cancer cells. In case of PRMT1-driven methylation, proper mitochondrial Ca(2+) uptake is reestablished by increased activity of uncoupling protein 2 (UCP2), pointing to an importance of these proteins for cancer cell survival and activity.
Oncology (8)
Neoplasms (7), Carcinoma (3), Lung Neoplasms (2), more mentions
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
This decrease was associated with the AMPT-induced reduction of monetary earning in HC in contrast to rBN participants. Our findings contributed to the theory of a desensitized dopaminergic system in bulimia nervosa. A disrupted processing of reward magnitudes and effort costs might increase the probability of maintenance of bulimic symptoms.Neuropsychopharmacology accepted article preview online, 06 November 2017.
Bulimia (5), more mentions
20. Screen Violence and Youth Behavior.  
Date: 11/02/2017
Pediatrics 
The vast majority of laboratory-based experimental studies have revealed that violent media exposure causes increased aggressive thoughts, angry feelings, physiologic arousal, hostile appraisals, aggressive behavior, and desensitization to violence and decreases prosocial behavior (eg, helping others) and empathy. Still, to more fully understand the potential for long-term harm from media violence exposure, the field is greatly in need ...
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