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Upper Respiratory Infections
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Your search returned 48 results
from the time period: last 90 days.
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The Journal of infectious diseases
Data on the relative contribution of influenza virus and other respiratory pathogens to respiratory infections in community-dwelling ... incidence in the consecutive seasons was 7.2% and 11.6%, and influenza virus caused 18.9% and 34.2% of ILI episodes... pathogen were detected in 80% of the ILI events with influenza virus, coronaviruses, rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza viruses, and Haemophilus influenzae being the most common ...
Human Influenza (11), Infections (3), Respiratory Tract Infections (2), more mentions
The Journal of allergy and clinical immunology
Hundreds of virus species and subtypes have been associated with these conditions, with influenza viruses (IFV), respiratory syncytial virus (RSV) and the rhinoviruses (RV) being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission or even just the ...
Vaccines (1)
Respiratory Tract Infections (2), Human Influenza (1), more mentions
The Journal of infectious diseases
Abstract: Respiratory syncytial virus (RSV) is increasingly recognized as a significant cause of adult respiratory illness. We evaluated routine viral testing and discharge diagnoses for identifying RSV and influenza burden. Polymerase chain reaction results performed in adults during emergency room visits or hospitalizations were reviewed. Peak RSV activity preceded influenza activity by 8 weeks.
Human Influenza (5), more mentions
Importance: Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. Objective: To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Design, Setting, and Participants: Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted in 54 family practices in England among 401 adults with acute cough and at least 1 lower respiratory tract symptom not requiring immediate antibiotic treatment and with no history of chronic pulmonary disease or use of asthma medication in the past 5 years. Interventions: Two 20-mg prednisolone tablets (n = 199) or matched placebo (n = 202) once daily for 5 days. Main Outcomes and Measures: The primary outcomes were duration of moderately bad or worse cough (0 to 28 days; minimal clinically important difference, 3.79 days) and mean severity of symptoms on days 2 to 4 (scored from 0 [not affected] to 6 [as bad as it could be]; minimal clinically important difference, 1.66 units). Secondary outcomes were duration and severity of acute lower respiratory tract infection symptoms, duration of abnormal peak flow, antibiotic use, and adverse events. Results: Among 401 randomized patients, 2 withdrew immediately after randomization, and 1 duplicate patient was identified. Among the 398 patients with baseline data (mean age, 47 [SD, 16.0] years; 63% women; 17% smokers; 77% phlegm; 70% shortness of breath; 47% wheezing; 46% chest pain; 42% abnormal peak flow), 334 (84%) provided cough duration and 369 (93%) symptom severity data. Median cough duration was 5 days (interquartile range [IQR], 3-8 days) in the prednisolone group and 5 days (IQR, 3-10 days) in the placebo group (adjusted hazard ratio, 1.11; 95% CI, 0.89-1.39; P = .36 at an α = .05). Mean symptom severity was 1.99 points in the prednisolone group and 2.16 points in the placebo group (adjusted difference, -0.20; 95% CI, -0.40 to 0.00; P = .05 at an α = .001). No significant treatment effects were observed for duration or severity of other acute lower respiratory tract infection symptoms, duration of abnormal peak flow, antibiotic use, or nonserious adverse events. There were no serious adverse events. Conclusions and Relevance: Oral corticosteroids should not be used for acute lower respiratory tract infection symptoms in adults without asthma because they do not reduce symptom duration or severity. Trial Registration: Identifier: ISRCTN57309858.
Infectious Diseases (4)
Respiratory Tract Infections (7), Cough (5), Asthma (3), more mentions
Lancet (London, England)
Determining the burden of respiratory syncytial virus disease: the known and the unknown..
Journal of clinical microbiology
A viral whole genome sequencing strategy, based on PCR amplification followed by Next-generation Sequencing, was used to investigate a nosocomial RSV-B outbreak in a hematology-oncology and stem cell transplant unit. RSV-B genomes from 16 patients and healthcare workers (HCWs) suspected to be involved in the outbreak were compared to RSV-B genomes acquired from outpatients during the same time period but epidemiologically unrelated to the outbreak. Phylogenetic analysis of the whole genome identified a cluster of 11 patients and HCWs with an identical RSV-B strain which were clearly distinct from strains recovered from individuals unrelated to the outbreak. Sequences variation of the G gene alone was insufficient to distinguish the outbreak strains from the outbreak unrelated strains, thereby demonstrating that WGS is valuable for local outbreak investigation.
Blood Disorders and Hematology (1), Oncology (1), more mentions
The Journal of infectious diseases 
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Africa, Western. DescriptorName: Basic Reproduction Number. DescriptorName: Coronavirus Infections. DescriptorName: Data Collection. DescriptorName: Epidemiological Monitoring. DescriptorName: Hemorrhagic Fever, Ebola. DescriptorName: Humans. DescriptorName: Internet. DescriptorName: Republic of Korea. DescriptorName: Spatio-Temporal Analysis. Abstract: The paucity of traditional epidemiological data during epidemic emergencies calls for alternative data streams to characterize the key features of an outbreak, including ...
Ebola Hemorrhagic Fever (6), Coronavirus Infections (1), more mentions
Emerging infectious diseases
... syndrome cases imported into the United States, comprising all passengers and crew on 4 international and domestic flights and 1 bus. Of 655 contacts, 78% were interviewed; 33% had serologic testing. No secondary cases were identified Keyword: Aircraft. Keyword: MERS-CoV. Keyword: Middle East respiratory syndrome coronavirus... Keyword: coronavirus. Keyword: disease notification. Keyword: disease outbreaks. Keyword: respiratory infections. Keyword: travel.
Respiratory Tract Infections (1), Zoonoses (1), more mentions
AbstractText: The pathogenesis, viral localization and histopathological features of Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) in human are not sufficiently described... Keyword: Middle East respiratory syndrome coronavirus. Keyword: electron microscopy. Keyword: extra pulmonary. Keyword: histopathology. Keyword: pulmonary. Keyword: renal.
Infectious Diseases (1)
Infections (4), Acute Kidney Injury (1), Myositis (1), more mentions
The Annals of thoracic surgery
Middle East respiratory syndrome-coronavirus (MERS-CoV) resembles a severe form of community-acquired pneumonia initially reported in Saudi Arabia in 2012. The MERS-CoV epidemic poses a big challenge because of its high mortality. In January 2015, a patient who was potentially incubating MERS-CoV arrived from the emergency department of another hospital and was admitted with acute coronary ...
Cardiovascular Diseases (1)
Acute Coronary Syndrome (1), Pneumonia (1), more mentions
Bulletin of the World Health Organization 
... the economic impact of achieving forecasted coverages for vaccination against Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella, Streptococcus pneumoniae and yellow fever ... le taux de couverture prévu est atteint, des vaccinations contre Haemophilus influenzae type B, l'hépatite B, le papillomavirus humain, l'encéphalite japonaise, la rougeole, Neisseria meningitidis sérogroupe A, le rotavirus, la rubéole, Streptococcus pneumoniae et la fièvre jaune ...
Vaccines (3), Infectious Diseases (2)
Hepatitis B (2), Rubella (1), Japanese Encephalitis (1), more mentions
Antimicrobial agents and chemotherapy
Generally, clarithromycin-resistant Haemophilus influenzae with a nonsense mutation in acrR exhibited susceptibility to azithromycin, although one strain was found to be nonsusceptible. We aimed to clarify the differences. This strain had an amino acid substitution, Arg327Ser, in AcrB. Introduction of this substitution into H. influenzae Rd caused an increase in the MIC of azithromycin, suggesting that this substitution contributed ...
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 
We assessed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNα/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory or relapsed NMIBC. Methods In this open-label, multicenter (n = 13), parallel-arm, phase II study ( identifier: NCT01687244), 43 patients with HG BCG-refractory or relapsed ...
Oncology (2)
Urinary Bladder Neoplasms (2), Hematuria (1), Nocturia (1), more mentions
Diagnostic microbiology and infectious disease 
Abstract: We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group ... Keyword: Middle East respiratory syndrome coronavirus.
Pneumonia (4), Respiratory Failure (2), Infections (2), more mentions
Lancet (London, England) 
... esterase inhibitor, 13 (45%) of 29 patients given the once-weekly regimen, and eight (29%) of 28 patients given placebo. Headache (twice-weekly treatment) and nasopharyngitis (once-weekly treatment) were the most common adverse events. Two (7%) adverse events (fatigue and headache) were deemed possibly related to treatment with recombinant human C1 esterase inhibitor, but both resolved without additional treatment.
Headache (2), Allergy (1), Nasopharyngitis (1), more mentions
Cell reports 
The major hit from our screen, B4GALNT2, showed inhibitory activity against influenza viruses with an α2,3-linked sialic acid receptor preference. B4GALNT2 overexpression prevented the infection of every avian influenza virus strain tested, including the H5, H9, and H7 subtypes, which have previously caused disease in humans... Keyword: avian influenza virus. Keyword: glycotransferase.
Avian Influenza (4), Human Influenza (4), Infections (4), more mentions
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Macrolide efflux encoded by mef(E)/mel and ribosomal methylation encoded by erm(B) confer most macrolide resistance in Streptococcus pneumoniae. Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) in 2000 reduced macrolide-resistant invasive pneumococcal disease (MR-IPD) due to PCV7 serotypes (6B, 9V, 14, 19F, and 23F).In this study, the impact of PCV7 and PCV13 on MR ...
Vaccines (2), Infectious Diseases (1), more mentions
The European respiratory journal
Abstract: Non-typeable Haemophilus influenzae (NTHi) is the most common pathogen in primary ciliary dyskinesia (PCD) patients. We hypothesised that abnormal ciliary motility and low airway nitric oxide (NO) levels on airway epithelial cells from PCD patients might be permissive for NTHi colonisation and biofilm development.We used a primary epithelial cell co-culture model to investigate NTHi infection.
Infectious Diseases (3)
Kartagener Syndrome (2), Infections (1), more mentions
Nature communications 
... enzyme digestion and high-throughput sequencing) to enable in vivo quantitative analyses of upstream regulatory sequences. Using the genome-reduced bacterium Mycoplasma pneumoniae, we show that ELM-seq has a large dynamic range and causes minimal toxicity. We use ELM-seq to determine key sequences (known and putatively novel) of promoter and untranslated regions that influence transcription and translation efficiency.
Infectious Diseases (1), more mentions
Antimicrobial agents and chemotherapy
Resveratrol has been shown to inhibit the replication of several viruses, including herpes simplex viruses 1 and 2, papillomaviruses, severe acute respiratory syndrome virus, and influenza virus. Alone, resveratrol does not inhibit HIV-1 infection of activated T cells, but it does synergize with nucleoside reverse transcriptase inhibitors in these cells to inhibit reverse transcription.
Infectious Diseases (1), Immune System Diseases (1)
Infections (3), Severe Acute Respiratory Syndrome (1), Herpes Simplex (1), more mentions
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