Correction: In patients presenting to the emergency department with skin and softtissueinfections what is the diagnostic accuracy of point-of-care ultrasonography for the diagnosis of abscess compared to the current standard of care? A systematic review and meta-analysis..
AbstractText: To investigate predictors of 10-year risk of revision and 1-year risk of prostheticjointinfection (PJI) and death following total hip/total knee arthroplasty (THA/TKA) in (1) patients with rheumatoid arthritis (RA) compared with patients with osteoarthritis (OA); and (2) patients with RA treated with biological ...
Immune System Diseases (3), Muscular and Skeletal Diseases (2) Rheumatoid Arthritis (3), Infections (3), Osteoarthritis (1), more mentions
... retrospective cohort study was assembled with 679 patients undergoing revision knee (340 cases) or hip arthroplasty (339 cases) for presumed aseptic causes. For all patients three or more separate intra-operative cultures were obtained. Patients were diagnosed with a previously unsuspected prostheticjointinfection (PJI) if two or more cultures were positive with the same organism... Keyword: Prostheticjointinfection.
AbstractText: Tubercular prostheticjointinfection (TB-PJI) is an uncommon complication. Lack of evidence of systemic tuberculosis and clinical suspicion could bring a delay in the time of the diagnosis. The aims of this study are to underline the importance of awareness and suspicion of mycobacterial infection in the differential diagnosis in PJI and to evaluate the appropriateness of different ...
Cardiovascular Diseases (2) Infections (3), Tuberculosis (2), more mentions
Abstract: Older adults are at increased risk for septic arthritis and prostheticjointinfections (PJI), owing at least in part to comorbid conditions and frailty... Targeting important modifiable and nonmodifiable risk factors may prevent or reduce the burden of jointinfections in older adults... Keyword: Prostheticjointinfection. Keyword: Septic arthritis.
Muscular and Skeletal Diseases (4) Infections (5), Bacterial Arthritis (4), Staphylococcal Infections (1), more mentions
... aimed at describing the use of oral cyclines (i.e., doxycycline and minocycline) as suppressive antibiotic therapy (SAT) in patients with periprosthetic jointinfections (PJIs) AbstractText: Medical charts of all patients with surgical revisions for PJIs who were given cycline-based SAT because of a high ... Keyword: Periprosthetic jointinfection.
... defensin proteins in synovial fluid using the Synovasure lateral flow device and to determine its diagnostic reliability and accuracy compared with the prostheticjointinfection (PJI) criteria produced by the Musculoskeletal Infection Society (MSIS) AbstractText: A cohort of 121 patients comprising 85 total knee arthroplasties and 36 ... Keyword: Prostheticjointinfection.
The study aimed to retrospectively assess if strain typing of Propionibacterium acnes could help to distinguish between infection and contamination in isolates recovered from the central nervous system (CNS) and prosthetic joints (PJs). This was a retrospective cohort of all Propionibacterium species isolates from the Barnes-Jewish Hospital (St Louis, MO, USA) clinical microbiology laboratory from 2011 to 2014. Available frozen isolates were recovered, and strain type (IA-1, IA-2, IB, II, III, or nontypeable class A or B) was determined via polymerase chain reaction (PCR)-based methods. For CNS isolates, P. acnes was considered pathogenic if treating physicians administered ≥7 days of directed antibiotic therapy against P. acnes. During the study period, Propionibacterium species was isolated from clinical cultures 411 times. 152 isolates were available for analysis. Of the 152 isolates, 140 were confirmed to be P. acnes, 61 of which were from the CNS (45 contaminants, 16 infections). Strain type IA-1 was more common (50.0%, 8 out of 16) among CNS infections than among contaminants (22.2%, 10 out of 45). For PJ isolates 61.3% (19 out of 31) met the criteria for infection. The predominant strain type for CNS infection was IA-1 and for PJ isolates, IB. Strain type IA-1 was isolated more often in patients with CNS infections, which may indicate a predilection of this strain type to cause CNS infection. Future research should prospectively evaluate strain typing as a means of assisting in the diagnosis of CNS infections and confirm our findings.
OBJECTIVE: High plantar pressures are implicated in the development of diabetes-related foot ulcers. Whether plantar pressures remain high in patients with chronic diabetes-related foot ulcers over time is uncertain. The primary aim of this study was to compare plantar pressures at baseline and three and six months later in participants with chronic diabetes-related foot ulcers (cases) to participants without foot ulcers (controls).
METHODS: Standardised protocols were used to measure mean peak plantar pressure and pressure-time integral at 10 plantar foot sites (the hallux, toes, metatarsals 1 to 5, mid-foot, medial heel and lateral heel) during barefoot walking. Measurements were performed at three study visits: baseline, three and six months. Linear mixed effects random-intercept models were utilised to assess whether plantar pressures differed between cases and controls after adjusting for age, sex, body mass index, neuropathy status and follow-up time. Standardised mean differences (Cohen's d) were used to measure effect size.
RESULTS: Twenty-one cases and 69 controls started the study and 16 cases and 63 controls completed the study. Cases had a higher mean peak plantar pressure at several foot sites including the toes (p = 0.005, Cohen's d = 0.36) and mid-foot (p = 0.01, d = 0.36) and a higher pressure-time integral at the hallux (p<0.001, d = 0.42), metatarsal 1 (p = 0.02, d = 0.33) and mid-foot (p = 0.04, d = 0.64) compared to controls throughout follow-up. A reduction in pressure-time integral at multiple plantar sites over time was detected in all participants (p<0.05, respectively).
CONCLUSIONS: Plantar pressures assessed during gait are higher in diabetes patients with chronic foot ulcers than controls at several plantar sites throughout prolonged follow-up. Long term offloading is needed in diabetes patients with diabetes-related foot ulcers to facilitate ulcer healing.
Endocrine Disorders (9), Anti-Obesity and Weight Loss (2) Foot Ulcer (8), Diabetes Mellitus (7), Diabetic Foot (1), more mentions
AbstractText: Skin and softtissueinfections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA. Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin. Of these, dalbavancin and oritavancin offer extended dosing intervals AbstractText: We performed a systematic review, network meta-analysis and ...
Infectious Diseases (2) Soft Tissue Infections (2), more mentions
... is limited AbstractText: To use whole-genome sequences to describe the diversity and distribution of resistance mechanisms among community-associated S. aureus isolates AbstractText: S. aureus isolates from skin and softtissueinfections (SSTIs) and nasal colonization were collected from patients within 10 primary care clinics from 2007 to 2015.
Anti-Obesity and Weight Loss (1) Soft Tissue Infections (2), more mentions
Mycobacterium abscessus complex (MABC) is the most common non-tuberculous mycobacterium that causes complicated skin and softtissueinfections (cSSTIs. The selection of antimycobacterial agents for successful treatment of such infections is a critical issue.To investigate the antimicrobial susceptibility patterns of MABC isolates from skin and soft tissue to a variety of antimycobacterial agents.Sixty-seven MABC isolates were ...
NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. perfringens type A strain CVCC 46 were 0.91 μM. Based on the fractional inhibitory concentration index (FICI) result, an additive or synergic effect was observed between NZ2114 (FICI = 0.5~0.75) or MP1102 (FICI = 0.375~1.0) and antibiotics. The flow cytometry, scanning and transmission electron microscopy analysis showed that both NZ2114 and MP1102 induced obviously membrane damage, such as the leakage of cellular materials, partial disappearance of the cell membrane and membrane peeling, as well as retracting cytoplasm and ghost cell. The gel retardation and circular dichroism (CD) detection showed that NZ2114 and MP1102 could bind to C. perfringens genomic DNA and change the DNA conformation. Moreover, NZ2114 also interfered with the double helix and unwind the genomic DNA. The cell cycle analysis showed that C. perfringens CVCC 46 cells exposed to NZ2114 and MP1102 were arrested at the phase I. These data indicated that both NZ2114 and MP1102 have potential as new antimicrobial agents for gas gangrene infection resulting from resistant C. perfringens.
Infectious Diseases (1) Gas Gangrene (4), Infections (1), more mentions
The Journal of bone and joint surgery. American volume
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DescriptorName: Time Factors. AbstractText: Despite the availability of a battery of tests, the diagnosis of periprosthetic jointinfection (PJI) continues to be challenging. Serum D-dimer assessment is a widely available test that detects fibrinolytic activities that occur during infection. We hypothesized that patients with PJI may have a high level of circulating D-dimer and that the presence of ...
AbstractText: Two large randomized trials recently demonstrated efficacy of methicillin-resistant Staphylococcus aureus (MRSA)-active antibiotics for drained skinabscesses... emergency departments, demonstrating superiority of trimethoprim-sulfamethoxazole (320/1,600 mg twice daily for 7 days) compared with placebo for patients older than 12 years with a drained skinabscess.