In Ontario, Canada, during 1998-2010, nontuberculousmycobacteria (NTM) from pulmonary sites comprised 96% of species/patient combinations isolated; annual rates of isolation and ... NTM isolates from nonpulmonary sites comprised 4% of species/patient combinations; annual rates and cases were ... NTM increases were driven exclusively by pulmonary isolates and disease.
Abstract: Limited data are available describing extrapulmonary nontuberculousmycobacteria (NTM) infections in the general population... We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites ... Compared with pulmonary NTM infection, more extrapulmonary infections are caused by rapid-growing NTM species ... Keyword: extrapulmonary nontuberculousmycobacteria... Keyword: nontuberculousmycobacteria.
Cardiovascular Diseases (1) Infections (7), Tuberculosis (1), more mentions
Nontuberculousmycobacteria (NTM) are increasingly recognized as clinically significant pathogens in this population ... risk (0 to 1 points, n = 820 [77.3%], 3-year NTM risk 1.2%), intermediate risk (2 points, n = 161 [15.4%], 3-year NTM risk 7.1%), and high risk (3 points, n = 56 [5.4%], 3-year NTM risk 14.3 ...
Infections (5), Viremia (3), Graft vs Host Disease (1), more mentions
Background: Poor knowledge of health care workers may be responsible for the under-diagnosis and low notification of Buruli ulcer (BU) in high-burden settings. This study assessed health care workers' knowledge, attitude and risk perception of BU in Southern Nigeria.
Methods: We conducted a cross-sectional survey among 186 health care workers recruited from 58 health facilities in four states of Southern Nigeria. A semi-structured interviewer-administered questionnaire was administered to all participants.
Results: The overall mean knowledge score was 8.8±2.7 (maximum 15). Only 29.0% (54/186) of the respondents had a good knowledge of BU. The mean (SD) attitude score was 4.5±1.2 (maximum 6). Also, 61.3% (114/) of the respondents had a good attitude towards BU. The overall mean (SD) risk perception score was 2.6±1.3 (maximum 5). Only 26.3% (49/) of the respondents had a good risk perception of BU disease. Previous training was an independent predictor of good knowledge (aOR 4.6), good attitude (aOR 3.8) and good risk perception (aOR 2.9) to BU.
Conclusions: Health care workers in endemic settings of Nigeria have poor knowledge of and poor risk perception of BU disease. Training of health care workers is recommended to address the identified gaps to ensure earlier diagnosis and referral to specialist centres.
We explored in detail the nationwide existence of Mycobacterium riyadhense in Saudi Arabia. In 18 months, 12 new cases of M. riyadhense infection were observed, predominantly among Saudi nationals, as a cause of pulmonary disease. M. riyadhense may be emerging as a more common pathogen in Saudi Arabia.
Mycobacterium gordonae, a low pathogenicity organism, is rarely implicated in skin and soft tissue infections. We present a 77-year-old returned diabetic traveler from rural Sudan with cutaneous M. gordonae infection. Several months of ciprofloxacin, rifampin and ethambutol led to resolution of his plaque, without signs of recurrence at 6-month follow-up.
Chronic pulmonary aspergillosis (CPA) is associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). An Aspergillus-positive respiratory specimen often reflects colonization, and thus the clinical significance of Aspergillus isolation in MAC-LD patients is not well understood. The objective of this study was to investigate the clinical characteristics and outcomes of MAC-LD patients in whom Aspergillus was isolated from respiratory specimens. We performed a retrospective review of the medical records of 329 MAC-LD patients. We compared the characteristics and mortality rates between patients with Aspergillus isolation and those without. All Aspergillus species detected from respiratory specimens within the follow-up period were reviewed. Aspergillus was detected in 40 (12.2%) of the 329 patients. There were no significant differences in the clinical characteristics and mortality rates between patients with and without Aspergillus isolation. Among the 40 patients with Aspergillus isolation, 9 (22.5%) developed CPA. CPA was most often caused by A. fumigatus. In the 40 Aspergillus-positive patients, patients with A. fumigatus isolation had a significantly higher mortality rate than those without (P < 0.001). The multivariate Cox proportional hazards model showed older age (P = 0.050), presence of respiratory comorbidities (P = 0.008), hypoalbuminemia (P < 0.001), and isolation of A. fumigatus (P = 0.005) to be prognostic factors for mortality in MAC-LD patients. There was no significant difference in the mortality rates between patients with Aspergillus isolation and those without. However, isolation of A. fumigatus may be associated with poor prognosis in MAC-LD patients.
Lung Diseases (2), Hypoalbuminemia (1), Pulmonary Aspergillosis (1), more mentions
... and hematopoietic stem cell transplant recipients but carry significant morbidity and mortality. Donor screening strategies for tuberculosis should be emphasized in high-risk populations. Both tuberculosis and nontuberculous mycobacterial infections can have pulmonary and extrapulmonary manifestations of infections. Recommended treatment regimens typically involve multiple drugs with significant adverse effects and drug interactions Keyword: Mycobacterium tuberculosis. Keyword: Nontuberculousmycobacteria. Keyword: Transplantation.
Cardiovascular Diseases (3), Stem Cell Research (2) Infections (4), Tuberculosis (3), more mentions
We report two unrelated cases of tenosynovitis caused by Mycobacterium malmoense in kidney transplant recipients. Both patients received immunosuppression and were referred to our tertiary hospital because of persisting complaints lasting >6 months not responding to corticosteroids or surgery. The mycobacterial cultures were positive for the slow-growing M. malmoense after several weeks of incubation. The patient in Case 1 was treated with a combination of surgical debridement and antibiotics, whereas the patient in Case 2 was only treated surgically. Both cases illustrate the doctor's delay in diagnosing mycobacterial infections, and remind us that nontuberculous mycobacterial infections should be part of the differential diagnosis of tenosynovitis, especially in immunocompromised patients. This article is protected by copyright. All rights reserved.
Infectious Diseases (1) Tenosynovitis (4), Infections (3), more mentions
Abstract: Nontuberculousmycobacteria are human pathogens with increasing incidence and prevalence worldwide... Keyword: atypicalmycobacteria. Keyword: bacteria. Keyword: nontuberculous mycobacterium. Keyword: pulmonary. Keyword: tuberculosis and other mycobacteria.
Cardiovascular Diseases (1) Lung Diseases (1), Tuberculosis (1), more mentions
Abstract: Typical cutaneous non-tuberculousmycobacteria (NTM) infections show a histopathology pattern of granulomas with admixed Langhans giant cells, and abscesses may ... Anti-NTM treatment was initiated... RDD-like histopathological features, which may be a pitfall in the diagnosis of disseminated cutaneous NTM infections Keyword: Mycobacterium kansasii... Keyword: non-tuberculousmycobacteria.
Infections (5), Sinus Histiocytosis (3), Granuloma (1), more mentions