Abstract: During influenza pandemics, secondary pneumococcal infections cause excessive mortality... immunization with an attenuated pneumococcal pep27 mutant provides protection from influenzavirusinfection, and also from secondary pneumococcal challenge... to reduce the morbidity and mortality due to secondary pneumococcal infections during influenza pandemics Keyword: Streptococcus pneumoniae. Keyword: influenza A virus.
Vaccines (3) Human Influenza (5), Pneumococcal Infections (4), Secondary Infections (1), more mentions
... pathogen were detected in 80% of the ILI events with influenzavirus, coronaviruses, rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza viruses, and Haemophilus influenzae being the most common ... Influenza vaccination reduced influenzavirusinfection by 73% (95% confidence interval [CI], 26%-90%) and 51 ... Vaccination reduces the number of influenzavirusinfections but not the overall number of ILI episodes: other pathogens ...
Vaccines (1) Human Influenza (16), Infections (4), Respiratory Tract Infections (3), more mentions
Although miRNA's involvement in the regulation of influenzavirusinfection and endothelial cell (EC) function has been well documented, little is known about the miRNA profiles in influenza-infected endothelial cells ... the present study aims to explore the differential miRNAs in influenzavirus-infected ECs and analyze their target genes involved in EC permeability ...
Human Influenza (12), Infections (5), Acute Lung Injury (1), more mentions
Background: Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness of influenza vaccine for older adults has been reported to be lower than for younger adults, and the impact of frailty on vaccine effectiveness (VE) and outcomes is uncertain. We aimed to study VE against influenza hospitalization in older adults, focusing on the impact of frailty.
Methods: We report VE of trivalent influenza vaccine (TIV) in people ≥65 years of age hospitalized during the 2011-2012 influenza season using a multicenter, prospective, test-negative case-control design. A validated frailty index (FI) was used to measure frailty.
Results: Three hundred twenty cases and 564 controls (mean age, 80.6 and 78.7 years, respectively) were enrolled. Cases had higher baseline frailty than controls (P = .006). In the fully adjusted model, VE against influenza hospitalization was 58.0% (95% confidence interval [CI], 34.2%-73.2%). The contribution of frailty was important; adjusting for frailty alone yielded a VE estimate of 58.7% (95% CI, 36.2%-73.2%). VE was 77.6% among nonfrail older adults and declined as frailty increased.
Conclusions: Despite commonly held views that VE is poor in older adults, we found that TIV provided good protection against influenza hospitalization in older adults who were not frail, though VE diminished as frailty increased.
Clinical Trials Registration: NCT01517191.
DescriptorName: Humans. DescriptorName: Influenza A Virus, H3N2 Subtype... In the humaninfluenzavirus, reassortment happens most frequently between co-existing variants within the same lineage. This process breaks genetic linkage and fitness correlations between viral genome segments, but the resulting net effect on viral fitness has remained unclear. In this paper, we determine rate and average selective effect of reassortment ...
Abstract: Influenza is an acute viral respiratory disease that affects persons of all ages and is associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands of deaths during annual winter epidemics of variable severity in the United States. Elderly persons have the highest influenza-associated hospitalization and mortality rates.
Immune System Diseases (2) Human Influenza (4), Infections (1), more mentions
The growth of digital communication technologies for public health is offering an unconventional means to engage the general public in monitoring community health. Here we present Influenzanet, a participatory system for the syndromic surveillance of influenza-like illness (ILI) in Europe. Through standardized online surveys, the system collects detailed profile information and self-reported symptoms volunteered by participants resident in the Influenzanet countries. Established in 2009, it now includes 10 countries representing more than half of the 28 member states of the European Union population. The experience of 7 influenza seasons illustrates how Influenzanet has become an adjunct to existing ILI surveillance networks, offering coherence across countries, inclusion of nonmedically attended ILI, flexibility in case definition, and facilitating individual-level epidemiological analyses generally not possible in standard systems. Having the sensitivity to timely detect substantial changes in population health, Influenzanet has the potential to become a viable instrument for a wide variety of applications in public health preparedness and control.
Abstract: Lysine acetylation is a post-translational modification known to regulate protein functions. Here we identify several acetylation sites of the influenza A virus nucleoprotein (NP), including the lysine residues K77, K113 and K229... These results suggest that NP acetylation at K77, K113 and K229 impacts multiple steps in viral replication of influenza A viruses.
The viral ribonucleoprotein (vRNP) of influenza A virus is formed by virion RNA (vRNA), viral polymerase complex, and ... hnRNP A2/B1 may act as a positive regulator in viral RNA synthesis of influenza A virus... research demonstrate that host proteins can regulate the replication of influenza A virus by interacting with NP.
... T and NK cell mediated immunity (CMI) responses in pandemic influenza A(H1N1)pdm09 (pdm09) virusinfected non-vaccinated pregnant women participating in the Norwegian Influenza Pregnancy ... higher frequencies of IFNγ+ CD8+ T cells responding to pdm09 virus or conserved CD8 T cell-restricted influenza A virus epitopes, compared to controls ...
Vaccines (1) Human Influenza (10), Infections (3), H1N1 Influenza (2), more mentions
Abstract: The present study conducted serosurveillance for the presence of antibody to pandemic influenza A (H1N1) 2009 virus (H1N1pdm virus) in archival serum samples collected between 2009 and 2013 from 317 domestic elephants living in 19 provinces situated in various parts of Thailand. To obtain the most accurate data, hemagglutination-inhibition (HI) assay was employed as the screening test; and ...
Human Influenza (2), Infections (2), H1N1 Influenza (2), more mentions
DescriptorName: Influenza A virus... Abstract: Influenza A virus (IAV) continues to pose an enormous and unpredictable global public health threat, largely due to the continual evolution of escape from preexisting immunity and the potential for zoonotic emergence. Understanding how the unique genetic makeup and structure of IAV populations influences their transmission and evolution is essential for developing more-effective vaccines ...
Abstract: Influenzavirusinfection remains one of the largest disease burdens on humans ... Influenza-associated bacterial co-infections contribute to severe disease and mortality during pandemic and seasonal ... The mechanisms of severe morbidity following influenza-bacteria co-infections mainly include failure of an antibacterial immune response and pathogen ... study of mechanisms of severe disease, caused by bacterial co-infections following influenzavirus pathogenesis, are summarized.
Human Influenza (7), Coinfections (6), Infections (2), more mentions
DescriptorName: Amino Acid Substitution. DescriptorName: Antigens, Viral. DescriptorName: Hemagglutinin Glycoproteins, InfluenzaVirus... DescriptorName: Influenza A Virus, H3N2 Subtype. DescriptorName: Influenza Vaccines. DescriptorName: Influenza, Human. Abstract: The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health.
... September 23, 2017,* the United States experienced low-level seasonal influenzavirus activity; however, beginning in early September, CDC received reports of a small number of localized influenza outbreaks caused by influenza A(H3N2) viruses ... 21-September 23, 2017, CDC confirmed a total of 33 influenza variant virus(†) infections; two were influenza A(H1N2) variant (H1N2v) viruses (Ohio) and 31 were influenza A(H3N2) variant (H3N2v) viruses (Delaware , Maryland , North Dakota , Pennsylvania , and ...
Vaccines (3) Human Influenza (17), H1N1 Influenza (2), Infections (1), more mentions
DescriptorName: Cameroon. DescriptorName: Epitopes. DescriptorName: Evolution, Molecular. DescriptorName: Glycosylation. DescriptorName: Hemagglutinin Glycoproteins, InfluenzaVirus... DescriptorName: Influenza A Virus, H3N2 Subtype... The presence of several antigenic site mutations among H3N2 virus strains between 2014-2016 influenza seasons in Cameroon confirms the progressing evolution of circulating H3N2 strains.
When hemagglutinin (HA) glycoproteins from influenza A virus (IAV) are expressed in cells, ER stress is induced, resulting in rapid HA degradation via proteasomes... Here, we used influenza A virus (IAV) to investigate how host innate immunity is activated. We found that IAV hemagglutinin (HA) glycoproteins induce ER stress, resulting in HA degradation via ERAD and consequent inhibition of IAV ...
Immune System Diseases (5) Human Influenza (4), Infections (2), more mentions