DescriptorName: Hepatitis E. DescriptorName: Hepatitis E virus... AbstractText: To determine the clinical phenotype and outcome in hepatitis E virus-associated neuralgic amyotrophy (HEV-NA) AbstractText: Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA were compared with NA cases without evidence ...
Infectious Diseases (5) Hepatitis E (4), Amyotrophic Neuralgia (2), Hepatitis (1), more mentions
AbstractText: Antiviral treatment for patients in HBeAg-positive chronic hepatitis B virus (HBV) infection is still controversial. We assessed whether antiviral treatment reduces liver disease progression in those patients AbstractText: This study included consecutive patients that tested positive for HBeAg with an HBV DNA >20,000 IU/mL, ALT <40 IU/L and without evidence of cirrhosis in eight large ...
Immune System Diseases (7), Infectious Diseases (2) Cirrhosis (4), Infections (3), Hepatocellular Carcinoma (2), more mentions
McMaster PLUS Selected
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This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients AbstractText: The clinical data from 1322 hospitalised patients with acute decompensation of cirrhosis or severe liver ...
Infectious Diseases (4) Cirrhosis (5), Chronic Liver Failure (3), Hepatitis B (3), more mentions
Abstract: Epidemiologic studies examining the association between hepatitis C virus and chronic kidney disease have yielded conflicting findings... of chronic kidney disease were nearly 3-fold higher in hepatitis C virus-infected persons with genotype 2 compared with genotype 1 ... Hepatitis C virus genotype distributions differ in regions around the world.
Kidney Disease (4), Infectious Diseases (4) Chronic Kidney Diseases (4), Hepatitis C (4), more mentions
AbstractText: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection has resulted in high rates of disease cure; however, not enough specialists currently are available to provide care AbstractText: To determine the efficacy of HCV treatment independently provided by nurse practitioners (NPs), primary care physicians (PCPs), or specialist ...
Infectious Diseases (2), Immune System Diseases (1) Infections (4), Hepatitis C (2), Cirrhosis (1), more mentions
Little is known about the role of MAIT cells in livers of patients with chronic hepatitis C virus (HCV) infection and their fate after antiviral therapy AbstractText: We collected blood samples from 42 patients with chronic HCV infection who achieved a sustained virologic response after 12 weeks of treatment with ...
Infectious Diseases (3), Immune System Diseases (3) Infections (5), Fibrosis (2), Cirrhosis (1), more mentions
Advances in autoimmunehepatitis that transform current concepts of pathogenesis and management can be anticipated ... To describe the advances that are likely to become transformative in autoimmunehepatitis, based on the direction of current investigations.Pertinent abstracts were identified ... and cellular interventions constitute the next generation of transformative advances in autoimmunehepatitis.
Infectious Diseases (4), Immune System Diseases (4) Autoimmune Hepatitis (4), more mentions
Abstract: Hepatitis A virus (HAV) infection is an ancient disease and likely to have afflicted mankind since humans first began to live in groups large enough ... hepatic infection it causes in humans, including recently recognized aspects of its molecular virology, evolution, natural history, pathogenesis, epidemiology and prevention Keyword: Hepatitis A virus.
Infectious Diseases (7), Vaccines (1) Hepatitis A (4), Jaundice (3), Hepatitis (2), more mentions
OBJECTIVE: Infections are common and associated with complications and mortality in acute liver failure (ALF). The temporal relationship between ammonia and infection in ALF patients is unclear. We aimed to evaluate the predictors of infection and its relationship with arterial ammonia levels.
MATERIALS AND METHODS: Consecutive ALF patients hospitalized between January 2004 and December 2015, without signs of infection at/within 48 h of admission, were included. Occurrence of infection after 48 h was documented and ammonia levels were estimated for five consecutive days. Multivariate logistic regression analysis was used to assess factors associated with development of infection. Generalized estimating equations (GEE) were used to evaluate five-day time trend of ammonia in patients with and without infection.
RESULTS: Of 540 consecutive patients, 120 were infected at admission/within 48 h and were excluded. Of the rest 420 patients, 144 (34.3%) developed infection after 48 h and 276 (65.7%) remained non-infected. Infected patients had higher mortality than non-infected patients (61.8% vs 40.0%, p < .001). On multivariate analysis, presence of cerebral edema(HR 2.049; 95%CI, 1.30-3.23), ammonia level on day 3 of admission (HR 1.006; 95%CI, 1.003-1.008), and model for end stage liver disease (MELD) score (HR 1.051; 95%CI, 1.026-1.078) were associated with development of infection. GEE showed group difference in serial ammonia values between infected and non-infected patients indicating lack of ammonia decline in infected patients.
CONCLUSIONS: Cerebral edema, elevated ammonia on day 3, and higher MELD score predict the development of infection in ALF. Ammonia persists at high levels in infected patients, and elevated ammonia on day 3 is associated with complications and death.
... risk of liver decompensation and death among patients with chronic viralhepatitis.We conducted a population wide cohort study using a hospital ... Adults with chronic viralhepatitis without prior liver decompensation were identified from 2000 to 2012 ... competing risk.A total of 69 184 patients with chronic viralhepatitis (2053 statin users and 67 131 statin non-users) were ...
AbstractText: Hepatitis B vaccine is an effective measure to prevent hepatitis B virus infection. Whether chronic hepatitis C virus (HCV) infection decreases humoral and cell-mediated immunity responses to hepatitis B vaccination is still controversial AbstractText: Patients with chronic HCV infection who were not in treatment and healthy controls, matched ...
Infectious Diseases (17), Vaccines (6) Hepatitis B (12), Chronic Hepatitis C (4), Infections (3), more mentions
Background: Postpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described. Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women.
Methods: Pregnant women at Cairo University were screened for anti-HCV antibodies and HCV RNA, and viremic women were tested for quantitative HCV RNA at 3, 6, 9, and 12 months postpartum. Spontaneous clearance was defined as undetectable viremia twice at least 6-months apart. Associations between viral load and demographic, obstetrical, HCV risk factors, and interleukin-28B gene (IL28B) polymorphism (rs12979860) were assessed.
Results: Of 2514 women, 97 (3.9%) had anti-HCV antibodies, 54 (2.1%) were viremic and of those, 52 (2.1%) agreed to IL28B testing. From pregnancy until 12 months postpartum, IL28B-CC allele women had a significant viral decline (P = .009). After adjusting, the IL28B-CC allele had a near significant difference compared to the CT allele (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.75,1.00; P = .05), but not the TT allele (OR, 0.91; 95% CI, 0.61,1.38; P = .64). All 14/52 (26.9%) women who subsequently cleared were among the 15 with undetectable viremia at 12 months, making that time point a strong predictor of subsequent clearance (sensitivity = 100%, specificity = 97.4%, positive predictive value = 93.3%, negative predictive value = 100%).
Conclusions: IL28B-CC genotype and 12-month postpartum undetectable viremia were the best predictors for viral decline and subsequent clearance. These 2 predictors should influence clinical decision making.
Infectious Diseases (2) Viremia (3), Chronic Hepatitis C (1), Hepatitis C (1), more mentions
Interferon-based regimens are associated with a substantial survival benefit for persons infected with hepatitis C virus (HCV. Survival data with direct-acting antiviral agents are not available. We conducted this study to quantify the effect of paritaprevir/ritonavir, ombitasvir, dasabuvir (PrOD) and ledipasvir/sofosbuvir (LDV/SOF) regimens upon mortality.In the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES ...
Infectious Diseases (3), Immune System Diseases (2), Blood Disorders and Hematology (1) Hepatitis C (2), Cirrhosis (1), Chronic Kidney Diseases (1), more mentions