We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlate with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.
Infectious Diseases (1) Infections (1), Hepatitis C (1), more mentions
AbstractText: Chronic hepatitis C virus (HCV) infection is a major burden on individuals and health care systems. The Extension for Community Healthcare Outcomes (Project ECHO) enables primary care providers to deliver best-practice care for complex conditions to underserved populations. The US Congress passed the ECHO Act in late 2016, requiring the Department of Health and Human Services to investigate ...
Infectious Diseases (2) Infections (6), Hepatitis C (1), Chronic Hepatitis C (1), more mentions
AbstractText: Antiviral treatment for patients in HBeAg-positive chronic hepatitis B virus (HBV) infection is still controversial. We assessed whether antiviral treatment reduces liver disease progression in those patients AbstractText: This study included consecutive patients that tested positive for HBeAg with an HBV DNA >20,000 IU/mL, ALT <40 IU/L and without evidence of cirrhosis in eight large ...
Immune System Diseases (7), Infectious Diseases (2) Cirrhosis (4), Infections (3), Hepatocellular Carcinoma (2), more mentions
Abstract: The U.S. Department of Veterans Affairs (VA) is the nation's largest care provider for hepatitis C virus (HCV)-infected patients and is uniquely suited to inform national efforts to eliminate HCV. An extensive array of delivery of services, policy guidance, outreach efforts, and funding has broadened the reach and capacity of the VA to deliver direct-acting antiviral ...
Infectious Diseases (3), Immune System Diseases (2) Infections (4), Hepatitis C (3), more mentions
McMaster PLUS Selected
This article has been identified as especially clinically relevant or newsworthy by at least 3
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This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients AbstractText: The clinical data from 1322 hospitalised patients with acute decompensation of cirrhosis or severe liver ...
Infectious Diseases (4) Cirrhosis (5), Chronic Liver Failure (3), Hepatitis B (3), more mentions
... due to adverse events AbstractText: Treatment with MMF as rescue therapy for AIH appears well tolerated and is moderately effective in achieving an overall remission rate of 60. Response rates are lower and infection rates are higher in those with cirrhosis. Further prospective studies of MMF are warranted in this population Keyword: Mycophenolate. Keyword: autoimmunehepatitis. Keyword: cirrhosis. Keyword: remission.
Infectious Diseases (2), Immune System Diseases (2) Cirrhosis (3), Autoimmune Hepatitis (2), Liver Diseases (1), more mentions
AbstractText: Advances in autoimmunehepatitis that transform current concepts of pathogenesis and management can be anticipated ... To describe the advances that are likely to become transformative in autoimmunehepatitis, based on the direction of current investigations AbstractText: Pertinent abstracts were ... and cellular interventions constitute the next generation of transformative advances in autoimmunehepatitis.
Infectious Diseases (4), Immune System Diseases (4) Autoimmune Hepatitis (4), more mentions
... risk of liver decompensation and death among patients with chronic viralhepatitis AbstractText: We conducted a population wide cohort study using a ... Adults with chronic viralhepatitis without prior liver decompensation were identified from 2000 to 2012 ... risk AbstractText: A total of 69 184 patients with chronic viralhepatitis (2053 statin users and 67 131 statin non-users) were ...
Abstract: Hepatitis A virus (HAV) infection is an ancient disease and likely to have afflicted mankind since humans first began to live in groups large enough ... hepatic infection it causes in humans, including recently recognized aspects of its molecular virology, evolution, natural history, pathogenesis, epidemiology and prevention Keyword: Hepatitis A virus.
Infectious Diseases (7), Vaccines (1) Hepatitis A (4), Jaundice (3), Hepatitis (2), more mentions
OBJECTIVE: Infections are common and associated with complications and mortality in acute liver failure (ALF). The temporal relationship between ammonia and infection in ALF patients is unclear. We aimed to evaluate the predictors of infection and its relationship with arterial ammonia levels.
MATERIALS AND METHODS: Consecutive ALF patients hospitalized between January 2004 and December 2015, without signs of infection at/within 48 h of admission, were included. Occurrence of infection after 48 h was documented and ammonia levels were estimated for five consecutive days. Multivariate logistic regression analysis was used to assess factors associated with development of infection. Generalized estimating equations (GEE) were used to evaluate five-day time trend of ammonia in patients with and without infection.
RESULTS: Of 540 consecutive patients, 120 were infected at admission/within 48 h and were excluded. Of the rest 420 patients, 144 (34.3%) developed infection after 48 h and 276 (65.7%) remained non-infected. Infected patients had higher mortality than non-infected patients (61.8% vs 40.0%, p < .001). On multivariate analysis, presence of cerebral edema(HR 2.049; 95%CI, 1.30-3.23), ammonia level on day 3 of admission (HR 1.006; 95%CI, 1.003-1.008), and model for end stage liver disease (MELD) score (HR 1.051; 95%CI, 1.026-1.078) were associated with development of infection. GEE showed group difference in serial ammonia values between infected and non-infected patients indicating lack of ammonia decline in infected patients.
CONCLUSIONS: Cerebral edema, elevated ammonia on day 3, and higher MELD score predict the development of infection in ALF. Ammonia persists at high levels in infected patients, and elevated ammonia on day 3 is associated with complications and death.
AbstractText: Hepatitis B vaccine is an effective measure to prevent hepatitis B virus infection. Whether chronic hepatitis C virus (HCV) infection decreases humoral and cell-mediated immunity responses to hepatitis B vaccination is still controversial AbstractText: Patients with chronic HCV infection who were not in treatment and healthy controls, matched ...
Infectious Diseases (17), Vaccines (6) Hepatitis B (12), Chronic Hepatitis C (4), Infections (3), more mentions
In addition to liver disorders, Hepatitis C virus (HCV) is also associated with extrahepatic immune manifestations and B-cell non-Hodgkin lymphoma (NHL), especially marginal zone lymphoma, de novo or transformed diffuse large B-cell lymphoma and to a lesser extent, follicular lymphoma. Epidemiological data and clinical observations argue for an association between HCV and lymphoproliferative disorders.
Infectious Diseases (2), Oncology (2), Immune System Diseases (1) Lymphoma (4), Infections (3), Follicular Lymphoma (2), more mentions