DescriptorName: Lung Diseases. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Mycobacterium avium-intracellulare Infection. DescriptorName: Retrospective Studies. DescriptorName: Tomography, X-Ray Computed. AbstractText: Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described.
Lung Diseases (8), Bronchiectasis (4), Bronchiolitis (2), more mentions
... 1.05, 95% CI 1.02 to 1.08, p = 0.002), Staphylococcus aureus infection (HR 3.40, 95% CI 1.00 to 11.76; p = 0.05), infection with unknown microorganism (HR 12.50, 95% CI 2.97 to 52.63 ... HR 8.70, 95% CI 3.55 to 21.28; p <0.0001), whereas infection on pacemaker or defibrillator (HR 0.30, 95%CI 0.10 to ...
Endocarditis (3), Infections (3), Staphylococcal Infections (1), more mentions
The Global Polio Eradication Initiative has reduced the global incidence of polio by 99% and the number of countries with endemic polio from 125 to 3 countries. The Polio Eradication and Endgame Strategic Plan 2013-2018 (Endgame Plan) was developed to end polio disease. Key elements of the endgame plan include strengthening immunization systems using polio assets, introducing inactivated polio vaccine (IPV), and replacing trivalent oral polio vaccine with bivalent oral polio vaccine ("the switch"). Although coverage in the Eastern Mediterranean Region (EMR) with the third dose of a vaccine containing diphtheria, tetanus, and pertussis antigens (DTP3) was ≥90% in 14 countries in 2015, DTP3 coverage in EMR dropped from 86% in 2010 to 80% in 2015 due to civil disorder in multiple countries. To strengthen their immunization systems, Pakistan, Afghanistan, and Somalia developed draft plans to integrate Polio Eradication Initiative assets, staff, structure, and activities with their Expanded Programmes on Immunization, particularly in high-risk districts and regions. Between 2014 and 2016, 11 EMR countries introduced IPV in their routine immunization program, including all of the countries at highest risk for polio transmission (Afghanistan, Pakistan, Somalia, and Yemen). As a result, by the end of 2016 all EMR countries were using IPV except Egypt, where introduction of IPV was delayed by a global shortage. The switch was successfully implemented in EMR due to the motivation, engagement, and cooperation of immunization staff and decision makers across all national levels. Moreover, the switch succeeded because of the ability of even the immunization systems operating under hardship conditions of conflict to absorb the switch activities.
Vaccines (10) Poliomyelitis (15), Tetanus (2), Diphtheria (2), more mentions
DescriptorName: Staphylococcal Infections... day all-cause mortality AbstractText: Analyses included 36 868 patients in 124 hospitals (mean [SD] age, 66.4 [12.5] years; 36 036 [97.7%] male), including 19 325 (52.4%) with infection due to methicillin-resistant S aureus and 17 543 (47.6%) with infection due to methicillin-susceptible S aureus.
Abstract: NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positivebacteria... exposed to NZ2114 and MP1102 were arrested at the phase I. These data indicated that both NZ2114 and MP1102 have potential as new antimicrobial agents for gas gangrene infection resulting from resistant C. perfringens.
Infectious Diseases (1) Gas Gangrene (4), Infections (1), more mentions
DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Protective Factors. DescriptorName: Staphylococcal Infections. DescriptorName: Staphylococcus aureus. DescriptorName: Statistics as Topic. DescriptorName: Time. AbstractText: To ascertain whether persons treated with statins experience a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB) as compared with nonusers AbstractText: Using population-based medical registries, we conducted a case-control study including all adults with ...
DescriptorName: Mycobacterium Infections, Nontuberculous... From 2009 to 2015, the medical records of patients, with respiratory specimens positive for NTMs, visiting or admitted to two Okinawan hospitals, were retrospectively analyzed... Results indicate four hundred sixteen patients had bacterial cultures positive for NTM. The most common NTM was M. abscessus complex (MABC) (n = 127; 30.5%), followed by M. intracellulare (n = 85; 20.4.
DescriptorName: Mycobacterium Infections, Nontuberculous... presence of bronchiectasis are associated with pulmonary nontuberculous mycobacterial (NTM) infections. The biologic relationship between the body habitus and NTM infection is not well defined and the body habitus profile of ... University of Illinois Medical Center on patients with pulmonary NTM infections between 2010 and 2015.
Bronchiectasis (11), Infections (4), Communicable Diseases (1), more mentions
DescriptorName: Mycobacterium Infections, Nontuberculous... is a common cause of skin, soft tissue, and bone infections. However, disseminated M. abscessus infection that mimics cancer metastasis with an underlying relatively immunocompetent condition ... lymphadenopathy AbstractText: We report a case of disseminated M. abscessus infection, which involved parotid glands with multiple lymphadenopathies in a person ...
Oncology (5) Infections (5), Neoplasms (4), Lymphadenopathy (3), more mentions
Abstract: Antibiotic resistant bacterialinfections are a significant problem in the healthcare setting, in many ... species identification in many clinical microbiology laboratories and is well positioned to be applied towards antimicrobial susceptibility testing... This method was previously successfully applied to Gram-negative pathogens and mycobacteria; here, we evaluated this method with the Gram-positive pathogen Staphylococcus aureus ...
DescriptorName: Pseudomonas Infections... DescriptorName: Staphylococcal Infections... In cystic fibrosis (CF), an elevation of specific IgG4 has been associated with colonization and infection by Pseudomonas aeruginosa. IgG4 elevation may be a marker of chronic infection or inflammatory stimulation. The aim of this study was to explore the prevalence of elevated IgG4 levels in CF and its correlation with the major clinical ...
Cystic Fibrosis (3), Infections (2), Staphylococcal Infections (1), more mentions
Abstract: Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide... Further, using subtractive proteomics and modelomics approaches for target identification, a set of 23 proteins was selected as essential for the bacteria. Considering human as a host, eight of these proteins (glpX, nusB, rpsH, hisE, smpB, bioB, DIP1084, and ...
DescriptorName: Clostridium Infections... is an urgent need for rapid and accurate microbiological diagnostic assay for detection of Clostridium difficile infection (CDI... STATA 13.0 software was used to analyze the tests for sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic ...
Of the total number of readmissions due to infection, methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus ... 13.38% in FL, and 13.11% in MA.The rate of infection is similar across all 3 states and is a leading ... Programs to reduce the likelihood of MRSA or MSSA infection would reduce readmissions due to infection.
AbstractText: Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells AbstractText: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls. Single nucleotide polymorphisms (SNPs) were genotyped using Illumina HumanCoreExome BeadChips.
Autochthonous leprosy has been reported in New York City, where there are no wild armadillos. Recent autochthonous cases also have been reported in Georgia and Florida and blamed on armadillos, including cases with no known armadillo exposure. International migration needs to be considered as a cause of autochthonous leprosy.
Diffuse multibacillary leprosy of Lucio and Latapí is mainly reported in Mexico and Central America. We report a case in a 65-year-old man in Peru. He also had Lucio's phenomenon, characterized by vascular thrombosis and invasion of blood vessel walls by leprosy bacilli, causing extensive skin ulcers.
Multibacillary Leprosy (2), Leprosy (1), Thrombosis (1), more mentions
Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998-May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases-patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease. Risk factors associated with severe disease included age, time period (range of years of diagnosis), and location of lesions over a joint. We highlight the changing epidemiology and pathogenicity of M. ulcerans disease in Australia. Further research, including genomic studies of emergent strains with increased pathogenicity, are urgently needed to improve the understanding of disease to facilitate implementation of effective public health measures to halt its spread.