DescriptorName: Angioedema... Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam... propensity score-matching was conducted and hazard ratios computed for angioedema events by per-protocol and intent-to-treat analyses... suggest that levetiracetam has the same or lower risk for angioedema than phenytoin, which does not currently carry a labeled warning for angioedema ...
Neurological and Central Nervous System Diseases (1) Angioedema (10), Epilepsy (1), Adverse Drug Reaction (1), more mentions
Diagnosis is made clinically; anaphylaxis must be ruled out. Chronicurticaria is idiopathic in 80% to 90% of cases... In refractory chronicurticaria, patients can be referred to subspecialists for additional treatments, such as omalizumab or cyclosporine. More than one-half of patients with chronicurticaria will have resolution or improvement of symptoms within a year.
... allergies AbstractText: To compare the relative amounts of Akkermansia muciniphila, Clostridium leptum, Faecalibacterium prausnitzii, and Enterobacteriaceae as members of gut microbiota among patients with chronicurticaria (CU) and healthy controls AbstractText: A total of 20 patients with CU and 20 healthy individuals matched by age and sex participated in the ...
AbstractText: Emerging evidence suggests that chronicurticaria (CU) is associated with chronic, low grade, inflammatory process AbstractText: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database AbstractText: A cross-sectional study of CU patients ... All rights reserved Keyword: Chronicurticaria.
Anti-Obesity and Weight Loss (4), Cardiovascular Diseases (3), Endocrine Disorders (3) Urticaria (4), Hypertension (3), Obesity (3), more mentions
AbstractText: Comprehensive data regarding the epidemiology of chronicurticaria (CU) in general populations are scant AbstractText: To investigate the prevalence, incidence, and comorbidities of CU in general population AbstractText: The data were sourced from the National Health Insurance Research Database (NHIRD) for 2009-2012. Patients who had a primary/secondary ICD-9-CM diagnosis code of 708.1, 708.8, or 708.9 ...
... in airways and the skin are extensively discussed, MC-mediated disorders of the GI tract remain relatively uncommon. Since the GI tract is one of the three main environment-interacting tissues, it is reasonable that MC-mediated disorders of the GI may have the same weight and impact as asthma or chronicurticaria (CU. This article is protected by copyright.
Urticaria (2), Irritable Bowel Syndrome (1), Asthma (1), more mentions
... CSU versus PsO of all severities (overall PsO), mild and moderate/severe PsO.his retrospective cross-sectional analysis compared data from adult patients with chronicurticaria (CU), used as a proxy for CSU, and PsO from the National Health and Wellness Survey in France, Germany, Italy, Spain, and the United ...
BACKGROUND: In early 2015, clinicians throughout Zambia noted a range of unpredictable adverse events after the administration of propofol, including urticaria, bronchospasm, profound hypotension, and most predictably an inadequate depth of anesthesia. Suspecting that the propofol itself may have been substandard, samples were procured and sent for testing.
METHODS: Three vials from 2 different batches were analyzed using gas chromatography-mass spectrometry methods at the John L. Holmes Mass Spectrometry Facility.
RESULTS: Laboratory gas chromatography-mass spectrometry analysis determined that, although all vials contained propofol, its concentration differed between samples and in all cases was well below the stated quantity. Two vials from 1 batch contained only 44% ± 11% and 54% ± 12% of the stated quantity, whereas the third vial from a second batch contained only 57% ± 9%. The analysis found that there were no hexane-soluble impurities in the samples.
CONCLUSIONS: None of the analyzed vials contained the stated amount of propofol; however, our analysis did not detect additional contaminants that would explain the adverse events reported by clinicians. Our results confirm the presence of substandard propofol in Zambia; however, anecdotal accounts of substandard anesthetic medicines in other countries abound and warrant further investigation to provide estimates of the prevalence and scope of this global problem.
Urticaria (2), Bronchial Spasm (2), Hypotension (2), more mentions
Cleaved high-molecular weight kininogen (cHK) in plasma is a biomarker for bradykinin formation. We developed an immuno-assay to detect cHK in plasma. cHK plasma levels are increased in asymptomatic C1-INH-HAE patients, and increase further during angioedema attacks..
Angioedema is frequently categorized into histamine- or bradykinin-mediated disease... Histaminergic angioedema is the most frequent cause of angioedema... It is further classified into angioedema presenting with or without urticaria. Some patients with acute angioedema may have disease that becomes chronic... basophils are central to the underlying pathophysiology of histamine-mediated angioedema.
... inhibitors are the most common classes of drugs that cause angioedema. Drug-induced angioedema is known to occur via mechanisms mediated by histamine, bradykinin ... Nonallergic angioedema occurs in patients with genetic variants that affect metabolism or ... The mainstay in treatment of nonallergic drug-induced angioedema is cessation of the offending agents.
Infectious Diseases (2), Muscular and Skeletal Diseases (1) Angioedema (5), more mentions
Hereditary angioedema (HAE) is an autosomal-dominant disorder owing to mutations in the C1 inhibitor gene... Angioedema can be peripheral, abdominal, or laryngeal. The typical duration of episodes is 3 days. Therapies include C1 inhibitor replacement for prophylaxis or acute therapy, whereas inhibition of kallikrein or blockade at the bradykinin receptor level can interrupt acute episodes of swelling.
AbstractText: Severe attacks of hereditary angioedema (HAE) are debilitating and potentially life threatening, and can increase anxiety and the use of medical resources AbstractText: This post hoc assessment evaluated recombinant human C1 esterase inhibitor (rhC1-INH) used to treat acute severe HAE attacks AbstractText: In a double-blind, randomized-controlled ...
... of life (HR-QoL) is impaired in patients with hereditary angioedema (HAE) but has notyet been satisfactorily described AbstractText: To study ... RAND Corporation Short Form 36 (RAND-36), the disease-specific Angioedema Quality of Life instrument (AE-QoL), the recently introduced Angioedema Activity Score (AAS) form, and questionnaires on sick leave and ...
Angioedema (2), Hereditary Angioedema (2), Depressive Disorder (2), more mentions
AbstractText: Hereditary angioedema (HAE) with normal C1-INH (HAEnCI) may be linked to specific mutations in the coagulation factor 12 (FXII ... Two women died by asphyxiation due to a tongue swelling AbstractText: Hereditary angioedema with a mutation in the PLG gene is a novel type of HAE... Keyword: hereditary angioedema.