AbstractText: Patients diagnosed with skin conditions have a higher risk of comorbid psychiatric conditions and ... not find an association between death by suicide and any skin condition including conditions where clinicians are generally concerned about the ... increased risk of death by suicide in individuals with major skindisorders in the US general population Keyword: Skindisorders.
In the course of the last 30 years, several studies have clearly documented that pruritus is a very frequent symptom of psoriasis and its impact on the patients' quality of life. The variety of available systemic treatments for psoriasis is increasing rapidly. Our objective was to assess their efficacy on pruritus based on a systematic literature review. A systematic literature search was performed using PubMed and Trip Database (from January 1990 to September 2016) to find published clinical trials for the treatments of psoriasis, then a meta-analysis was performed. Among 516 articles identified, 35 studies were retained in the systematic review. At baseline, the high prevalence of pruritus (80 to 100%) was confirmed. The meta-analysis included 13 trials using a 0 to 10 itch scale and highlighted that all treatments evaluated had a benefic impact on pruritus. Anti Il-17, JAK inhibitors, adalimumab, and apremilast were all shown to be effective in reducing pruritus in psoriasis with variable effect size magnitudes. Our systematic review highlights that systemic treatments, including UVB phototherapy, improve pruritus in psoriasis but that it is not necessarily correlated with lesion recovering. Nonetheless, these results must be displayed carefully because there are so many variable endpoints in different studies.
The activation and upregulation of IL-17 in prepsoriatic skin produces a "feed forward" inflammatory response in keratinocytes that is ... epidermal cell proliferation, and recruitment of leukocyte subsets into the skin... Emerging bispecific antibodies offer the potential for even better disease control, whereas small-molecule drugs offer future alternatives to the use of biologics and less costly long-term disease management Keyword: IL-17 ...
Dermatology (7), Muscular and Skeletal Diseases (1) Psoriasis (7), Psoriatic Arthritis (1), Hyperplasia (1), more mentions
... microRNA-143 (miR-143) expression in peripheral blood mononuclear cells (PBMCs) and disease severity in patients with psoriasis vulgaris... Disease severity in psoriasis vulgaris patients was graded with Psoriasis Lesions Area and ... findings suggest that miR-143 expression in PBMCs is negatively correlated the disease severity in psoriasis vulgaris Keyword: disease severity.
... A systematic literature search for psoriasis treatment in organ transplant patients was performed using MEDLINE and GOOGLE AbstractText: In mild to moderate disease, topical therapy should be a first-line treatment. In moderate to severe disease, first-line treatment is acitretin with narrow band ultraviolet light (NBUVB), NBUVB, or acitretin.
Nail psoriasis and onychomycosis can often be hard to differentiate clinically and may coexist, complicating each other's course. The aim of this study was to determine the prevalence of onychomycosis among patients with nail psoriasis not being treated with immunosuppressive agents, which constitute an independent risk factor for fungal infections. A cross-sectional study was performed. All adult patients with nail psoriasis who were not receiving antifungal and/or immunosuppressive treatment were recruited at the 2nd University Dermatology Department of Aristotle University of Thessaloniki from 10/2016 till 02/2017. If onychomycosis was clinically suspected, nail samples were collected and direct microscopy with 15% KOH solution and culture were performed. Target-NAPSI and DLQI score were also calculated. Of the 23 patients recruited, 20 were men and 3 were women, with a mean age of 53.43 years (48.25, 58.62), a mean target-NAPSI score of 10.72 (9.62, 11.77) and a mean DLQI score of 10.17 (7.46, 12.89). A total of 34.78% of patients tested positive for onychomycosis. Yeast were isolated in 37.50% of cases, non-dermatophyte filamentous fungi in 37.50% and T. rubrum in 12.50%. The prevalence of onychomycosis among nail psoriasis patients is higher than that among the general population of Greece (15%-20%). Yeast and moulds predominate in infection cases of nail psoriasis patients.
Dermatology (9) Psoriasis (8), Onychomycosis (7), Infections (2), more mentions
PURPOSE: The primary aim of this study was to evaluate the readability, understandability, suitability, and actionability of online psoriasis patient educational materials. A secondary aim was to identify areas for improvement.
MATERIALS AND METHODS: We conducted an evaluation study to assess online psoriasis patient educational materials from the American Academy of Dermatology and National Psoriasis Foundation available in July 2017. We used two validated assessment tools specific to online healthcare materials. Outcomes were expressed as percentages, where higher percentages corresponded to higher quality materials.
RESULTS: Overall, the educational materials had a mean understandability score (72.7%) that was understandable; a suitability score (58.8%) that was adequate; a reading grade level (10.5) that was not readable; and an actionability score (54.7%) that was not actionable. Areas of improvement include reading grade level, visual aids, word choice, specific steps for actions, and cultural appropriateness.
CONCLUSIONS: Online psoriasis patient educational materials are understandable and suitable, but they are written above the American Medical Association and National Institutes of Health's recommended 6th-8th grade reading level and are not actionable. Materials can benefit from decreasing reading grade level, including more visual elements, incorporating more actionable items, and being culturally inclusive.
BACKGROUND/AIMS: Fumaric acid esters (FAEs) are a well-established efficacious systemic treatment for psoriasis. Recent recommendations from the European Medicines Agency suggest monitoring of full blood count every 4 weeks for the duration of therapy for psoriasis. The aim of our study was to assess the incidence of lymphopenia in patients taking FAEs and the impact of recent recommendations for our practice.
METHODS: We reviewed 151 patients treated with FAEs for psoriasis between December 2013 and 2015.
RESULTS: Lymphopenia <700 × 109/L was detected within the last 12 months in 36/151 (24%) and lymphopenia <500 × 109/L in 10/151 (7%). Of 39 patients no longer on treatment, 7 (18%) stopped because of persistent lymphopenia.
CONCLUSION: The implementation of these recommendations would have significant resource implications and also likely influence the acceptability of FAEs to patients. Cessation of FAEs necessitates the need for alternative therapy, commonly biologic therapy.
Pathological, virological and immunological investigations were carried out on biopsied skin lesion, and peripheral blood mononuclear cells between the 2nd and ... In the context of HEV-associated cutaneous T cell lymphoproliferative disorders, antiviral treatment could be considered a first-line treatment instead of chemotherapy Keyword: CD30-positive cutaneous T cell lymphoproliferative disorder ...
Infectious Diseases (4), Immune System Diseases (3), Oncology (1) Lymphoproliferative Disorders (5), Hepatitis E (4), Infections (2), more mentions
AbstractText: To describe the minimal disease activity (MDA) rate over time in patients with psoriatic arthritis (PsA) receiving antitumour necrosis factor agents, evaluate prognostic factors of MDA achievement and identify the most common unmet criteria among MDA achievers AbstractText: Biologic Treatment Registry Across Canada (BioTRAC): ongoing ... Keyword: minimal disease activity.
Muscular and Skeletal Diseases (4), Dermatology (1), Immune System Diseases (1) Psoriatic Arthritis (3), Rheumatoid Arthritis (1), Psoriasis (1), more mentions
Abstract: The association between Lichenplanus (LP) and cancer has been under debate for decades... The risk of cancer was not increased in other locations where LP manifests (pharynx and skin... These data are important when considering treatment and follow-up of patients with LP diagnosis Keyword: Lichenplanus. Keyword: cancer risk.
Abstract: Human Leucocyte antigen (HLA) C*06:02 is identified as the allele associated with the highest risk for the development of the autoimmune skindisease psoriasis. However, the diversity and mode of peptide presentation by the HLA-C*06:02 molecule remains unclear. Here, we describe the endogenous peptide repertoire of approximately 3,000 sequences for HLA-C*06 ...
Dermatology (3), Immune System Diseases (1) Psoriasis (3), Skin Diseases (1), more mentions
AbstractText: psoriasis, a chronic relapsing inflammatory disease affecting primarily the skin, shows multiple comorbidities including depression, cardiovascular diseases and other relevant conditions... Inversely, psychosocial impairments may negatively influence the disease course AbstractText: To explore the feasibility of a model describing the interaction of psychosocial and clinical factors over the life ...
PURPOSE: To investigate the clinical effect of vitamin D3 supplementation on psoriasis from a community-dwelling population.
MATERIALS AND METHODS: Participants with psoriasis in a large randomized controlled trial examining the effect of vitamin D3 supplementation (100,000 IU monthly) in adults aged 50-84 years, were invited to participate in a psoriasis sub-study over 12 months. The primary outcome was the Psoriasis Area and Severity Index (PASI) and secondary outcomes were Physicians Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI). Trial identification number ACTRN12611000402943.
RESULTS: Twenty three were allocated to vitamin D and 42 to placebo. There was no significant difference at baseline between the two groups. Mean (SD) baseline 25-hydroxyvitamin D was 65.7 (25.7) nmol/L. There were no significant differences (p > 0.05) between the groups in all of the psoriasis outcome measures. Mean scores [95% CI] at 12 months for the Placebo vs. Vitamin D groups: PASI 2.2 [1.4, 3.0] vs 2.1 [1.0, 3.2]; PGA 1.4 [1.1, 1.7] vs 1.5 [1.1, 1.9]; PDI 2.1 [0.9, 3.2] vs 1.9 [0.4, 3.4]; and DLQI 2.5 [1.4, 3.6] vs 2.0 [0.5, 3.4].
CONCLUSION: Vitamin D3 supplementation (100,000 IU per month) is not recommended as a treatment for mild psoriasis.
... is unclear, and IL-33 expression in the lesional psoriatic skin after conventional systemic treatments has not been investigated... we aimed to compare IL-33 mRNA in patients' lesional skin samples and IL-33 protein expression in patients' serum before ... IL-33 mRNA levels in lesional skin and IL-33 protein levels in serum were downregulated after ...
... Functional outcomes are central in patients with chronic inflammatory musculoskeletal diseases... arthritis (PsA), a link that is still elusive in this disease AbstractText: We analysed 363 patients enrolled in the GO-REVEAL ... The effect of damage on function was seen in the disease activity-adjusted models using total mSvdHS (p=0.005), JSN (p ...
Muscular and Skeletal Diseases (3) Psoriatic Arthritis (3), Musculoskeletal Diseases (1), more mentions
In the present study, we found that the expression of PlxnB2 on keratinocytes was specifically increased in lesional skin of psoriasis patients, but not atopic dermatitis. Levels of soluble CD100 (sCD100) and membrane CD100 (mCD100) were elevated in sera of psoriasis patients and on keratinocytes of psoriatic skin, respectively. By binding to PlxnB2, sCD100 promoted the production of CXCL-1 ...
Dermatology (6) Psoriasis (5), Atopic Dermatitis (1), more mentions
Efficacy was analyzed by PASI50, PASI75, and PASI90, reflecting the improvement of skin lesions compared to the PASI-baseline... 7, 14.6%) and joint pain (n=5, 10.4%).Despite differences between real-world and trial patients, apremilast is safe and effective for the treatment of skin psoriasis in the daily practice.
Dermatology (7), Anti-Obesity and Weight Loss (1) Psoriasis (7), Arthralgia (1), Diarrhea (1), more mentions
... no studies have directly compared the health-related quality of life (HRQoL) in patients with moderate-to-severe manifestations of these conditions.To determine which disease is associated with more severe HRQoL impairment.Weighted averages of each of the following baseline HRQoL measures were determined and compared between HS and psoriasis ...
Dermatology (8) Psoriasis (6), Hidradenitis Suppurativa (2), more mentions