... the role of second opinions in pathology for diagnosis of melanocyticlesions is limited AbstractText: To assess current laboratory policies, clinical use ... of second opinions, and pathologists' perceptions of second opinions for melanocyticlesions AbstractText: Cross-sectional data collected from 207 pathologists in 10 US states who diagnose melanocyticlesions ...
... year-old woman was diagnosed with BRAF V600 mutation positive melanoma of unknown primary (MUP) with metastasis to the lung, liver ... Control CT performed after two months revealed disease stabilization... months of treatment with dabrafenib the patient developed disseminated skin lesions with extended seborrheic keratosis G2 (according to international common toxicity ... Keyword: melanoma.
... histologic evaluation have been the gold standard to diagnose skin tumors... RCM has been proven beneficial in management of various cutaneous lesions... clinical significance and future of RCM to diagnose common skin cancers... required to better compare the sensitivity and specificity of skin cancer diagnosis using RCM Keyword: Melanocytic skin cancer.
Abstract: The assessment of melanoma by light microscopy with hematoxylin-eosin staining remains an often ... Adjunctive genetic assessment to augment the diagnosis of melanoma includes comparative genomic hybridization or fluorescent in situ hybridization to ... Although these techniques may bolster the dermatopathologic assessment of melanoma, none of them, at the present time, are singularly diagnostic.
Oncology (6) Melanoma (6), Nevus (1), Epithelioid and Spindle Cell Nevus (1), more mentions
Abstract: Early diagnosis and treatment of melanoma improve survival... emerging that may augment the diagnosis, assessment, and management of melanoma but penetrance into everyday practice is low... be placed on the incorporation of technology for clinically suspicious pigmentedlesions to facilitate better, more cost-effective management Keyword: Diagnosis... Keyword: Melanoma.
... bioactive component of C. asiatica, on oxidative stress in human melanocytes and its possible mechanism of action AbstractText: In H2O2-induced oxidative conditions, madecassoside inhibited melanocyte dendrite retraction, improved MMP and reduced the accumulation of [Ca2 ... showed that madecassoside attenuated the damage of mitochondria in human melanocytes caused by oxidative stress.
... meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification ... Any given melanoma was 64% less likely to be nevus-associated than de ... CI] 0.29-0.44; P < .001; I(2) = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P ...
Hyperpigmentation of skin is caused by several factors. UV exposure, in addition to oxidative stress elevates inflammatory mediators stimulating melanogenesis. Herbal derived compounds for improving skin lightness are gaining interest as they are perceived to be milder, safer and healthier than fully synthetic products. This review briefly addresses the causes of skin hyperpigmentation and extensively summarizes the status of herbs currently used in skin lightening cosmetics. The properties of active compounds and their dose rate information is summarized where available, along with human or anamial relevant models for activity testing. This review will be of value to cosmetic formulators and dermatologists who are searching for naturally-derived ingredients for improving skin lightness, in line with consumer preference and expectations.
Abstract: Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies... 1227 participants in the international population-based Genes, Environment and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes ... and NRAS+ with older age relative to WT (BRAF-/NRAS-) melanomas (all P <0.05... Keyword: melanocytes... Keyword: pigmentation.
The calculated overall incidences of targeted cancer therapy-induced all-grade pigmentary changes in the skin and hair were 17.7% (95% confidence interval [CI], 11.9-25.4) and 21.5% (95% CI, 14.9-30.1), respectively. The relative risk of all-grade pigmentary changes of skin and hair were 93.7 (95% CI, 5.86-1497.164) and 20.1 (95% CI, 8.35-48.248.
... of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition. The depth of melanin pigment is the key factor to predict prognosis and treatment outcome... The evaluation of pigmentation using noninvasive tools helps define the level of pigmentation in the skin, pigmentation intensity, and guides therapeutic approaches ...
Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. When it does occur, the underlying inflammatory conditions should be sought and treated as the first step to reduce the progression of inflammation and PIH (which is an inflammatory consequence). If the inflammatory conditions subsides or there is no evidence of inflammation at the time of diagnosis, the treatments of PIH should be considered as the next step. Understanding the available treatment options helps the physician choose the appropriate treatment for each patient. Having a reproducible model for PIH is essential for the development of treatment modalities. The second article in this 2-part continuing medical education series on PIH specifically addresses the evidence that supports medical and procedural treatments of PIH and other forms of acquired hyperpigmentation. It also describes a PIH model and provides an algorithm for clinical practice along with discussion about the prevention of PIH.
Vitiligo is an acquired pigmentary disorder affecting 0.5-1% of the world's population... of life (QOL) due to the disfigurement caused by the disease [1... our scores to studies of patients with depression, chronic lung disease, psoriasis, atopic dermatitis, arthritis, cancer, congestive heart failure, myocardial infarction, type 2 diabetes, hypertension, and ...
Dermatology (2), Muscular and Skeletal Diseases (1), Cardiovascular Diseases (1) Vitiligo (4), Lung Diseases (1), Atopic Dermatitis (1), more mentions