... in dexamethasone suppression test (DST) during the diagnosis of primary pigmented nodular adrenocortical disease in Chinese adrenocorticotropic hormone-independent Cushing syndrome AbstractText: Retrospective study AbstractText: The patients diagnosed with primary pigmented nodular adrenocortical disease (PPNAD, n = 25), bilateral macronodular adrenal hyperplasia (BMAH, n = 27 ... Keyword: Primary pigmented nodular adrenocortical disease.
... the group reveals a novel and exciting mechanism of how mRNAs appear as potent miR sponges that sequester tumour-suppressive miRs, thereby lessening the function of these miRs. Here, they convincingly present how the sequestration of tumour-suppressive miR-16 can de-repress its target genes and promote melanoma progression.
AbstractText: Diffused-type giant cell tumor(Dt-GCT) is a rare, aggressive disorder of the joint synovium, bursa and tendon sheaths ... Patients were managed with open synovectomy for the tumor tissue and bone grafting for bony erosions... rays and MRI scans were used for evaluation of the tumor and bony erosions pre- and post-operatively.
Muscular and Skeletal Diseases (2) Giant Cell Tumors (3), Neoplasms (3), Pigmented Villonodular Synovitis (1), more mentions
Abstract: We report 2 ovarian sex cord-stromal tumors, a luteinized adult granulosa cell tumor and a cellular fibroma, with melanin pigment ... As far as we are aware, melanin pigment has not been described previously in an ovarian sex cord-stromal tumor, although it has been reported in a testicular Sertoli cell tumor ... We review ovarian neoplasms containing melanin pigment.
Sex Cord-Gonadal Stromal Tumors (3), Ovarian Neoplasms (1), Granulosa Cell Tumor (1), more mentions
... the present study was to evaluate the response of metastatic melanoma to treatment with ipilimumab by means of (18)F-FDG ... included in the analyses consisted of 41 patients with metastatic melanoma who underwent (18)F-FDG PET/CT before and after ... This cut-off was lower for lesions with larger functional diameters (three new lesions larger than 1.0 cm and two new lesions larger than 1.5 cm ...
... tea, exhibited a potent growth inhibitory effect on cisplatin-resistant ovarian cancer A2780/CP70 cells and were less cytotoxic to normal ovarian IOSE ... and TF2b induced apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells... TF2a and TF2b might help prevent and treat platinum-resistant ovarian cancer.
... selectively modulate immune function, targeted JAK inhibitors are promising candidates for some skin diseases such as psoriasis and atopic dermatitis... treatment with NB-UVB which is considered a gold standard therapy for both diseases... In psoriatic patients, the JAK1 level positively correlated with the female participants, disease duration and PASI change.
... and protein expression levels of elevated chemokines in HaCaT cells stimulated with interferon (IFN)-γ or tumor necrosis factor (TNF)-α were tested by quantitative real-time polymerase chain reaction and Luminex... In the epidermis of lesions, the expression levels of CCL5 and CXCL10 in active vitiligo were significantly increased.
... long-term efficacy and safety of this transplantation technique AbstractText: In this open-label and single-arm clinical trial, we enrolled 300 patients with stable vitiligo. We obtained a partial thickness normo-pigmented skin specimen from the patients' thigh-buttock junction with an area of one tenth to one third of the recipient site area... Keyword: Melanocyte. Keyword: Regenerative medicine.
Abstract: PDT is widely applied for the treatment of non-melanoma skin cancer pre-malignant and malignant lesions (actinic keratosis, basal cell carcinoma and in situ squamous cell ... Given the demonstrated role of cancer associated fibroblasts (CAFs) in tumor progression and the putative CAFs features of some cancer-prone genodermatoses fibroblasts, in this study, we have further characterized ...
... compared to controls, and tissue CXCL-10 +ve cells expression was stronger in active versus stable cases. Positive correlations were noted between the different serum and tissue markers. CXCL-10 was the most specific whereas IL-6 was the most sensitive serum marker to distinguish active from stable disease. This article is protected by copyright. All rights reserved Keyword: CD8.
AbstractText: Vitamin D has a role in variety of autoimmune diseases including vitiligo... in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and non responding skin after ... VDR expression was significantly higher in repigmented skin compared to non responding lesion.
Immune System Diseases (1) Vitiligo (8), Autoimmune Diseases (1), more mentions
... generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions... To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN Keyword: generalized... Keyword: oral lesions.
... systematically in keratinocytes in situ in highly, moderately and lightly pigmented human skin, classified according to their Individual Typological Angle (ITA ... of skin samples revealed qualitatively and quantitatively that in highly pigmented skin, although melanosomes are mostly isolated and distributed throughout the ... or melanophagosomes but that they present, similarly to melanosomes in melanocytes, features of non-acidic, non-degradative organelles.
Abstract: Vitiligo repigmentation is a complex process in which the melanocyte-depleted interfollicular epidermis (IE) is repopulated by melanocyte precursors from hair follicle (HF) bulge that proliferate, migrate, and differentiate into mature melanocytes on their way to the epidermis ... microdissection and subsequent whole transcriptome RNA sequencing of HF bulge melanocyte precursors, and compared their gene signature to that of regenerated mature epidermal melanocytes from the NBUVB-treated vitiligo skin ...
Abstract: Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat ... Patient 1 tolerated the infusion well but died from progressive disease after 6 weeks... transfer of tyrosinase-reactive TCR-transduced T cells into metastatic melanoma patients had clinical and/or biological activity without serious adverse ... Keyword: Metastatic melanoma.