... occurred on July 26, 2017 in 4 sessions: (1) benign pancreaticdiseases, (2) high-risk pancreaticdiseases, (3) diagnostic and therapeutics, and (4) new technologies ... themes included the need for large multicenter consortia of various pancreaticdiseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreaticdisorders, the technique of sampling pancreatic lesions, and the performance of ...
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6. Chronicpancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share consistent number of epidemiologic risk factors ...
... patients who have BTC with positive regional lymph nodes, including the impact of surgery and adjuvant therapy (AT), is unclear AbstractText: This was a retrospective cohort study of patients who had T1-T3N1M0 gallbladder cancer (GBC) and intrahepatic cholangiocarcinoma (IHC) in the National Cancer Database (2004-2012... Keyword: intrahepatic cholangiocarcinoma.
Abstract: Cholangiocarcinoma is a rare form of gastrointestinal cancer with a poor prognosis... RE provides a therapeutic option for patients with unresectable cholangiocarcinoma... Keyword: Cholangiocarcinoma. Keyword: Intrahepatic. Keyword: Liver radioembolisation (RE. Keyword: Treatment.
Oncology (1) Cholangiocarcinoma (4), Gastrointestinal Neoplasms (1), more mentions
OBJECT: Acute pancreatitis (AP) keeps as severe medical diagnosis and treatment problem. Early evaluation for severity and risk stratification in patients with AP is very important. Some scoring system such as acute physiology and chronic health evaluation-II (APACHE-II), the computed tomography severity index (CTSI), Ranson's score and the bedside index of severity of AP (BISAP) have been used, nevertheless, there're a few shortcomings in these methods. The aim of this study was to construct a new modeling including intra-abdominal pressure (IAP) and body mass index (BMI) to evaluate the severity in AP.
METHODS: The study comprised of two independent cohorts of patients with AP, one set was used to develop modeling from Jinling hospital in the period between January 2013 and October 2016, 1073 patients were included in it; another set was used to validate modeling from the 81st hospital in the period between January 2012 and December 2016, 326 patients were included in it. The association between risk factors and severity of AP were assessed by univariable analysis; multivariable modeling was explored through stepwise selection regression. The change in IAP and BMI were combined to generate a regression equation as the new modeling. Statistical indexes were used to evaluate the value of the prediction in the new modeling.
RESULTS: Univariable analysis confirmed change in IAP and BMI to be significantly associated with severity of AP. The predict sensitivity, specificity, positive predictive value, negative predictive value and accuracy by the new modeling for severity of AP were 77.6%, 82.6%, 71.9%, 87.5% and 74.9% respectively in the developing dataset. There were significant differences between the new modeling and other scoring systems in these parameters (P < 0.05). In addition, a comparison of the area under receiver operating characteristic curves of them showed a statistically significant difference (P < 0.05). The same results could be found in the validating dataset.
CONCLUSIONS: A new modeling based on IAP and BMI is more likely to predict the severity of AP.
... of the cause of pain effects long-term outcome after gallstone surgery AbstractText: A cohort study was conducted based on patients ... with SF-36 along with three single-items focusing on gallstone specific symptoms... who responded to the questionnaire SF-36 and the three gallstone specific items preoperatively... month and in patients convinced of having pain related to gallstones Keyword: Cholecystectomy.
Acute pancreatitis is one of the most common GI conditions requiring acute hospitalisation and has a rising incidence. In recent years, important insights on the management of acute pancreatitis have been obtained through numerous randomised controlled trials. Based on this evidence, the treatment of acute pancreatitis has gradually developed towards a tailored, multidisciplinary effort, with distinctive roles for gastroenterologists, radiologists and surgeons. This review summarises how to diagnose, classify and manage patients with acute pancreatitis, emphasising the evidence obtained through randomised controlled trials.
... submitted to the Federal Adverse Event Reporting System, we confirmed a previously reported risk of pancreatitis associated with eluxadoline. The need for hospitalization in at least half of these instances and a recent report of 2 fatalities should prompt reassessments of the agent's risk-benefit ratio Keyword: FAERS search. Keyword: IBS. Keyword: SphincterofOddidysfunction. Keyword: functional gastrointestinal disorders.
Pancreatitis (6), Irritable Bowel Syndrome (2), Sphincter of Oddi Dysfunction (1), more mentions
... disorder characterized by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease (IBD) is usually present and there is a high risk of cholangiocarcinoma and colorectal cancer... We survey advances made in the understanding of PSC pathogenesis, and summarize the ongoing efforts to develop an effective therapy based on these insights Keyword: Cholangiocarcinoma. Keyword: IgG4-associated cholangitis.
OBJECTIVE: Studies on the risk of acute pancreatitis in patients with primary Sjogren's syndrome (pSS) are limited. We evaluated the effects of pSS on the risk of acute pancreatitis in a nationwide, population-based cohort in Taiwan.
STUDY DESIGN: Population-based retrospective cohort study.
SETTING: We studied the claims data of the >97% Taiwan population from 2002 to 2012.
PARTICIPANTS: We identified 9468 patients with pSS by using the catastrophic illness registry of the National Health Insurance Database in Taiwan. We also selected 37 872 controls that were randomly frequency matched by age (in 5 year bands), sex and index year from the general population.
PRIMARY OUTCOME MEASURE: We analysed the risk of acute pancreatitis by using Cox proportional hazards regression models including sex, age and comorbidities.
RESULTS: From 23.74 million people in the cohort, 9468 patients with pSS (87% women, mean age=55.6 years) and 37 872 controls were followed-up for 4.64 and 4.74 years, respectively. A total of 44 cases of acute pancreatitis were identified in the pSS cohort versus 105 cases in the non-pSS cohort. Multivariate Cox regression analysis indicated that the incidence rate of acute pancreatitis was significantly higher in the pSS cohort than in the non-pSS cohort (adjusted HR (aHR) 1.48, 95% CI 1.03 to 2.12). Cyclophosphamide use increased the risk of acute pancreatitis (aHR 5.27, 95% CI 1.16 to 23.86). By contrast, hydroxychloroquine reduced the risk of acute pancreatitis (aHR 0.23, 95% CI 0.09 to 0.55).
CONCLUSION: This nationwide, retrospective cohort study demonstrated that the risk of acute pancreatitis was significantly higher in patients with pSS than in the general population.
... resistance, vascular dysfunction, systemic inflammation, genetic susceptibility and ultrasound proven gallstone disease or cholecystectomy in a population-based cross-sectional study ... total of 2650 participants were included, of whom 422 had gallstone disease. Associations between selected metabolic biomarkers and gallstone disease were estimated by multivariable logistic regression models and expressed ...
Endocrine Disorders (5), Anti-Obesity and Weight Loss (2) Gallstones (10), Insulin Resistance (4), Obesity (2), more mentions
... the diagnostic performance of contrast-enhanced ultrasound (CEUS) in differentiating combined hepatocellular cholangiocarcinomas (CHCs) from hepatocellular carcinomas (HCCs) and intrahepatic cholangiocarcinomas (ICCs) AbstractText: Thirty-three patients with pathologically confirmed CHC and matched control ... the differential diagnosis of CHC from HCC and ICC Keyword: combined hepatocellular cholangiocarcinoma (CHC... Keyword: intrahepatic cholangiocarcinoma (ICC.
Cholangiocarcinoma (5), Hepatocellular Carcinoma (2), Neoplasms (1), more mentions
... LI-RADS) version 2014 and their interreader agreement when comparing hepatocellular carcinoma (HCC) to intrahepatic cholangiocarcinoma (ICC) and combined tumor (cHCC-CC) AbstractText: The Institutional Review Board approved this HIPAA-compliant ... radiologists also achieved moderate interreader agreement in the assignment of the LR-M category Keyword: Cholangiocarcinoma... Keyword: Intrahepatic cholangiocarcinoma.
Cholangiocarcinoma (4), Hepatocellular Carcinoma (3), Neoplasms (2), more mentions
AbstractText: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronicpancreatitis (CP) is poorly characterised... Keyword: chronicpancreatitis. Keyword: genetic rearrangement.
Longstanding inflammation and the degree of immunosuppression as a result of IBD treatment appear to be the main driving factors for IBD-related carcinogenesis. This review provides an update on the clinical and pathological features of IBD-related intestinal and extraintestinal malignancies Keyword: Cholangiocarcinoma. Keyword: Colorectal cancer. Keyword: Crohn's disease.
Oncology (2), Immune System Diseases (2), Cardiovascular Diseases (1) Colorectal Neoplasms (2), Ulcerative Colitis (2), Lymphoma (2), more mentions
AbstractText: We sought to validate the commonly used prognostic models and staging systems for intrahepatic cholangiocarcinoma (ICC) in a large multi-center patient cohort AbstractText: The overall (OS) and disease free survival (DFS ... AJCC staging for ICC performed reasonably, although its overall discrimination was only modest-to-good Keyword: intrahepatic cholangiocarcinoma.
... aim of this study was to investigate plasma levels of serotonin, calcitonin and calcitonin gene-related peptide (CGRP) in the course of acute pancreatitis (AP) taking organ failure, etiology and severity into consideration AbstractText: Sixty consecutive patients with alcohol- or gallstone-induced AP were included over a 15-month period.
Pancreatitis (3), Respiratory Failure (1), Gallstones (1), more mentions
Epithelial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to biliary secretory functions and bile transport. Although ErbB receptors have been widely studied in cholangiocarcinoma (CCA), a malignancy of the biliary tract, knowledge of these receptors in biliary epithelium physiology and in non-malignant cholangiopathies is far from completed... Keyword: Cholangiocarcinoma. Keyword: Cholangiopathy.
Cholangiocarcinoma (2), Lithiasis (1), Sclerosing Cholangitis (1), more mentions