We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlate with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.
Infectious Diseases (1) Infections (1), Hepatitis C (1), more mentions
Using detailed data from a national dialysis provider, we determined HIV status by administrative codes and antiretroviral medication prescriptions, with hepatitis C virus (HCV) co-infection status provided by routinely measured serology. The survival on dialysis among 5348 individuals in the HIV(+) group and 1863 HIV(+)/HCV(+) individuals to a HIV(-)/HCV(-) reference cohort was compared.
Infectious Diseases (2), Kidney Disease (1) Coinfections (5), HIV Infections (4), Hepatitis C (2), more mentions
McMaster PLUS Selected
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AbstractText: Alcoholic hepatitis is a form of alcoholic liver disease, characterised by steatosis ... Typically, alcoholic hepatitis presents in people between 40 and 50 years of age. Alcoholic hepatitis can be resolved if people abstain from drinking, but the ... are used as anti-inflammatory drugs for people with alcoholic hepatitis... the benefits and harms of glucocorticosteroids in people with alcoholic hepatitis AbstractText: We identified trials through electronic searches in Cochrane Hepato ...
Abstract: Hepatitis B core antibody (anti-HBc) is considered the most sensitive serological marker for history of hepatitis B virus (HBV) infection ... HBc carriers, anti-HBc is present in the absence of hepatitis B surface antigen and hepatitis B surface antibody-a serological pattern known as "isolated anti ... article reviews the clinical significance and association of IAHBc with hepatitis C virus (HCV) co-infection, risk of HBV reactivation during ...
Infectious Diseases (7), Immune System Diseases (1) Hepatitis B (6), Infections (2), Hepatocellular Carcinoma (1), more mentions
AbstractText: Chronic hepatitis C virus (HCV) infection is a major burden on individuals and health care systems. The Extension for Community Healthcare Outcomes (Project ECHO) enables primary care providers to deliver best-practice care for complex conditions to underserved populations. The US Congress passed the ECHO Act in late 2016, requiring the Department of Health and Human Services to investigate ...
Infectious Diseases (2) Infections (6), Hepatitis C (1), Chronic Hepatitis C (1), more mentions
Abstract: Direct-acting antivirals have revolutionized the treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease, with implications for the timing of antiviral treatment among kidney transplant candidates and for the use of HCV viremic donors... Keyword: hepatitis c virus. Keyword: kidney transplantation.
Infectious Diseases (3), Immune System Diseases (1), Kidney Disease (1) Hepatitis C (2), Infections (1), Chronic Kidney Diseases (1), more mentions
We aimed to determine whether the risk is further increased among HIV-hepatitis B virus (HBV) co-infected patients in this setting... Incidence rates (IR) of serious HIV- and non-HIV-related morbidity were compared between patients stratified on hepatitis B surface antigen (HBsAg) status. Overall, 65 (10.3%) were HBsAg-positive, 29 (44.6%) of whom had HBV-DNA levels > 10 ...
Infectious Diseases (4), Immune System Diseases (2) Hepatitis B (3), Infections (1), Bacterial Infection (1), more mentions
AbstractText: Hepatic energy metabolism negatively relates to insulin resistance and liver fat ... γATP and Pi AbstractText: Adjusted for age, sex and BMI, hepatic γATP and Pi related to 2h-OGTT glucose (r=0.25 ... fatty acids, but not measures of insulin sensitivity partly affect hepatic phosphorus metabolites suggesting mutual interaction between hepatic energy metabolism and circulating metabolites in nondiabetic humans ...
Endocrine Disorders (2), Anti-Obesity and Weight Loss (1) Insulin Sensitivity (3), Diabetes Mellitus, Type 2 (1), Insulin Resistance (1), more mentions
... SOF) for 8 to 24 weeks is approved for the treatment of chronic hepatitis C virus infection (HCV... and to describe outcome of therapy in routine clinical practice AbstractText: The German Hepatitis C-Registry is a large national real-world cohort that analyses effectiveness and ... Keyword: German Hepatitis C-Registry.
Infectious Diseases (4), Immune System Diseases (1) Hepatitis C (2), Chronic Hepatitis C (2), Cirrhosis (1), more mentions
Abstract: Purpose To compare the benefits and harms of radiofrequency ablation (RFA) and hepatic resection (HR) and to test the consistency of currently available evidence. Materials and Methods PubMed, Embase, and the Cochrane Library were systematically searched for randomized controlled trials (RCTs) that compared the effects of HR and RFA for Barcelona Clinic Liver Cancer very early or early stage ...
Oncology (1) Hepatocellular Carcinoma (2), Liver Neoplasms (1), more mentions
AbstractText: Hepatic encephalopathy is the common manifestation of decompensated cirrhosis. The association between Helicobacter pylori (H. pylori) infection and hepatic encephalopathy has been shown in many epidemiologic studies... studies to estimate the association between H. pylori infection and hepatic encephalopathy AbstractText: A comprehensive literature review was conducted using MEDLINE ... studies that reported the association between H. pylori infection and hepatic encephalopathy.
Hepatic Encephalopathy (10), Infections (7), Cirrhosis (1), more mentions
Interrogation of rs17111557 revealed stronger associations in the subset of women with HIV/hepatitis C virus (HCV) coinfection (n = 408, 38% of women. Rs17111557 was also associated with low-density lipoprotein cholesterol levels in HIV/HCV coinfected (β: -10.4; 95% confidence interval: -17.9, -2.9; P = 0.007), but not in HIV monoinfected (β:1.2; 95% confidence interval: -6.3, 8.6; P = 0.76 ...
Infectious Diseases (2) Hepatitis C (2), HIV Infections (1), Coinfections (1), more mentions
AbstractText: Alcoholic hepatitis (AH) markedly decreases the urea synthesis capacity... the substrate-independent urea synthesis capacity, i.e., the functional hepatic nitrogen clearance (FHNC), in the patients at study entry and ... Patients with severe disease (Glasgow Alcoholic Hepatitis Score ≥9, n = 17) were randomized to receive either prednisolone ... may recover more rapidly following treatment with prednisolone Keyword: Alcoholic hepatitis.
... of vesatolimod is assessed after once-weekly treatment in chronic hepatitis B (CHB) infected patients suppressed on oral antiviral treatment AbstractText ... blind, randomized, placebo (PBO)-controlled study, 162 patients stratified by hepatitis B surface antigen (HBsAg) levels and serum HBeAg status were ... once-weekly, experimental immune-activating drug for the treatment of hepatitis B virus (HBV), is safe and well-tolerated in chronic ...
Infectious Diseases (6), Immune System Diseases (2) Hepatitis B (4), Chronic Hepatitis B (2), more mentions