Abstract: Gastroesophagealreflux disease (GERD) is the most prevalent gastrointestinal disorder in the United States, and leads to substantial morbidity, though associated mortality is rare. The prevalence of GERD symptoms appeared to increase until 1999. Risk factors for complications of GERD include advanced age, male sex, white race, abdominal obesity, and tobacco use.
Gastrointestinal Diseases (7), Anti-Obesity and Weight Loss (1) Gastroesophageal Reflux (7), Gastroparesis (1), Esophageal Stenosis (1), more mentions
Abstract: A detailed critique of objective measurements of gastroesophagealreflux disease (GERD) would improve management of patients suspecting of having reflux, leading to rational selection of treatment and better outcomes. Many diagnostic tests for GERD have been developed over the past decades. We analyze their development, positive- and negative-predictive values, and ability to predict response to treatment.
Gastrointestinal Diseases (8) Gastroesophageal Reflux (8), more mentions
... Group B was 11% (12/91 patients), and did not differ to a statistically significant extent (p = 0.533) AbstractText: Although the operative time for GERD in obese patients was prolonged in comparison with non-obese patients, there was no difference in the rate of postoperative recurrence Keyword: Body mass index (BMI. Keyword: Gastro-esophagealreflux disease (GERD. Keyword: Laparoscopic fundoplication.
Anti-Obesity and Weight Loss (5), Gastrointestinal Diseases (5) Gastroesophageal Reflux (5), Hernia (1), Peptic Esophagitis (1), more mentions
Laparoscopic Nissen fundoplication (LNF) has been the gold standard for the surgical management of Gastro-esophagealreflux disease (GERD. Laparoscopic anterior 180° fundoplication (180° LAF) is reported to reduce the incidence of postoperative complications while obtaining similar control of reflux. The present meta-analysis was conducted to confirm the value of the 2 techniques.PubMed, Medline, Embase, Cochrane Library, Springerlink ...
AbstractText: Gastroesophagealreflux disease (GERD) is commonly associated with obesity, and its surgical management is debatable AbstractText: The ... excess weight loss (%EWL), percentage of excess BMI loss (%EBMIL), and clinical assessment using the Gastro-esophagealReflux Health-Related Quality-of-Life (GERD-HRQOL) scale at 6 and 12 months AbstractText: The ...
Gastrointestinal Diseases (11), Anti-Obesity and Weight Loss (7) Gastroesophageal Reflux (11), Obesity (1), more mentions
Management of GERD commonly starts with an empiric trial of proton pump inhibitor (PPI) therapy and complementary lifestyle measures, for patients without alarm symptoms. Optimization of therapy (improving compliance and timing of PPI doses), or increasing PPI dosage to twice daily in select circumstances, can reduce persistent symptoms. Patients with continued symptoms can be evaluated with endoscopy and tests of esophageal physiology, to better determine their disease phenotype and optimize treatment. Laparoscopic fundoplication, magnetic sphincter augmentation, and endoscopic therapies can benefit patients with well-characterized GERD. Patients with functional diseases that overlap with or mimic GERD can also be treated with neuromodulators (primarily antidepressants), or psychological interventions (psychotherapy, hypnotherapy, cognitive and behavioral therapy). Future approaches to treatment of GERD include potassium-competitive acid blockers, reflux-reducing agents, bile acid binders, injection of inert substances into the esophagogastric junction, and electrical stimulation of the lower esophageal sphincter.
Gastrointestinal Diseases (5) Gastroesophageal Reflux (5), more mentions
AbstractText: The primary aim of this systematic review was to determine the safety, technical efficacy, and effectiveness of 48-hour wireless pH monitoring (WM) for gastroesophagealreflux disease (GERD), compared with no pH monitoring in patients who failed to tolerate a catheter. In the absence of eligible studies, the secondary aim was to determine these performance characteristics for WM relative ...
Gastrointestinal Diseases (5) Gastroesophageal Reflux (5), more mentions
PURPOSE: The prevalence of gastroesophagel reflux disease (GERD) has steadily increased. However, the association between GERD itself and the risk of pneumonia remains unclear. This study aimed to investigate the association between GERD and long-term risk of pneumonia and to identify the major risk factors for pneumonia in GERD patients.
METHODS: Using the Taiwan National Health Insurance Research Database, we identified patients who were newly diagnosed with GERD and treated with proton pump inhibitors (PPIs) from January 1, 2004 through December 31, 2010. Two groups comprising 15,715 GERD cases and 15,715 non-GERD matched controls were generated using propensity score matching, thereby making the differences in basic demographics, concomitant medication use, and comorbidities between the two groups inconsiderable.
RESULTS: Cumulative incidence of pneumonia was significantly higher in the patients with GERD than that in the non-GERD matched controls, with an adjusted HR of 1.48 (95% confidence interval [CI] = 1.31-1.67; P < 0.001) within 6-year follow-ups. Multivariate stratified analyses revealed similar results in many subgroups, with a highest risk in individuals younger than 40 years of age (HR = 2.17, 95% CI = 1.48-3.19). Crucially, patients with GERD using PPIs longer than 4 months were at a significantly increased risk of pneumonia than those who did not use PPIs or took PPIs less than 4 months.
CONCLUSIONS: GERD was significantly associated with long-term risk of pneumonia, especially in GERD with PPI use longer than 4 months or in the young population. Further prospective longitudinal studies should be conducted for validation and implementing clinical practice guidelines.
Gastrointestinal Diseases (13) Gastroesophageal Reflux (13), Pneumonia (7), more mentions
AbstractText: Dyspepsia and gastroesophagealreflux are highly prevalent in the general population, but they are believed to be separate entities ... a systematic review and meta-analysis to estimate the prevalence of dyspepsia in individuals with gastroesophagealreflux symptoms (GERS), and to quantify overlap between the disorders AbstractText: We searched MEDLINE, EMBASE, and ...
AbstractText: The gold standard for the objective diagnosis of gastroesophagealreflux disease (GERD) is ambulatory-pH monitoring off medications... Keyword: Gastroesophagealreflux disease (GERD. Keyword: Impedance-pH testing. Keyword: Proton pump inhibitor (PPI.
Gastrointestinal Diseases (11) Gastroesophageal Reflux (11), more mentions
AbstractText: Obstructive sleep apnea (OSA) is believed to be an important risk factor for gastroesophagealreflux disease (GERD... Keyword: Gastroesophagealreflux disease. Keyword: Obstructive sleep apnea. Keyword: Polysomnography.
Abstract: Fibromyalgia (FM) tends to co-exist with gastroesophagealreflux disease (GERD. This retrospective cohort study was conducted to determine the bidirectional association between FM and GERD, using a nationwide database, the National Health Insurance of Taiwan. We established two study arms, including 35117 FM patients in Arm 1 and 34630 GERD patients in Arm 2, newly diagnosed between 2000 ...
Gastrointestinal Diseases (13), Muscular and Skeletal Diseases (2) Gastroesophageal Reflux (13), Fibromyalgia (2), more mentions
AbstractText: Magnetic sphincter augmentation (MSA) is a surgical treatment option for patients with gastroesophagealreflux disease (GERD... Keyword: Gastroesophagealreflux disease. Keyword: LINX. Keyword: Magnetic sphincter augmentation. Keyword: Postoperative outcomes. Keyword: Proton pump inhibitors. Keyword: Quality of life.
AbstractText: The Los Angeles (LA) grade of reflux esophagitis (A to D) is assumed to reflect severity of the underlying gastroesophagealreflux disease (GERD. Thus, LA-D esophagitis patients might be expected to have the most conditions predisposing to GERD (eg, obesity, hiatal hernia), and the highest frequency of GERD symptoms AbstractText: The main goal of this study is to ...
Gastrointestinal Diseases (8), Anti-Obesity and Weight Loss (3) Gastroesophageal Reflux (9), Esophagitis (7), Hernia (4), more mentions
To determine the relationship between baseline impedance levels and gastroesophagealreflux, we retrospectively enrolled 110 patients (54 men and 56 female; mean age, 51 ± 14 years) with suspected gastroesophagealreflux disease (GERD) who underwent 24-h multichannel intraluminal impedance and pH monitoring. Patients were stratified according to symptom (typical or atypical) and reflux types (acid reflux, nonacid reflux [NAR], or ...
Gastrointestinal Diseases (5) Gastroesophageal Reflux (6), more mentions
... and Prescribed Drug Registry.Primary laparoscopic antireflux surgery due to gastroesophagealreflux disease in adults (>18 years).The outcome was recurrence of ... patients who underwent primary laparoscopic antireflux surgery, 17.7% experienced recurrent gastroesophagealreflux requiring long-term medication use or secondary antireflux surgery... surgery was associated with a relatively high rate of recurrent gastroesophagealreflux disease requiring treatment, diminishing some of the benefits of the ...
Gastrointestinal Diseases (2) Gastroesophageal Reflux (4), more mentions
OBJECTIVES: Symptomatic cervical heterotopic gastric mucosa also addressed as cervical inlet patch (CIP) may present in varying shapes and causes symptoms of laryngopharyngeal reflux (LPR) like globus sensations, hoarseness and chronic cough. Unfortunately, argon plasma coagulation, standard treatment of small symptomatic CIP, is limited in large CIP mainly due to concerns of stricture formation. Therefore, we aimed to investigate radiofrequency ablation (RFA), a novel minimal-invasive ablation method, in the treatment of CIP focusing on large symptomatic patches.
METHODS: Consecutive patients with macroscopic and histologic evidence of large (≥ 20mm diameter) heterotopic gastric mucosa were included in this prospective trial. Primary outcome was the complete macroscopic and histologic eradication rate of CIP. Secondary outcome measures were symptom improvement, quality of life, severity of LPR and adverse events.
RESULTS: Ten patients (females, n=5) underwent RFA of symptomatic CIP. Complete histological and macroscopic eradication of CIP was observed in 80% (females, n=4) of individuals after 2 ablations. Globus sensations significantly improved from median VAS score 8 (5-9) at baseline to 1.5 (1-7) after first ablation and 1 (1-2) after final evaluation (p<0.001). Mental health scores significantly increased from 41.4 (±8.5) to 54.4 (±4.4) after RFA (p=0.007). LPR improved significantly (p=0.005) with absence of strictures after a mean follow-up of 1.9 (±0.5) years.
CONCLUSIONS: This is the first study on RFA focusing on therapy of large symptomatic heterotopic gastric mucosa. Hereby, we demonstrate that this new technique can be successfully implemented in patients where treatment was limited so far. (NCT03023280) This article is protected by copyright. All rights reserved.
Pathologic Constriction (2), Laryngopharyngeal Reflux (2), Hoarseness (1), more mentions