DescriptorName: Adenocarcinoma. DescriptorName: African Americans. DescriptorName: Barrett Esophagus. DescriptorName: EsophagealNeoplasms. DescriptorName: Genetic Predisposition to Disease. DescriptorName: Humans. AbstractText: Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) are far more prevalent in European Americans than in African Americans. Hypothesizing that this racial disparity in prevalence might represent a genetic susceptibility, we used an admixture mapping approach to interrogate disease association with ...
Barrett Esophagus (4), Adenocarcinoma (3), Esophageal Neoplasms (1), more mentions
DescriptorName: Barrett Esophagus. DescriptorName: Biomarkers. DescriptorName: EsophagealNeoplasms. DescriptorName: Humans. DescriptorName: Immunohistochemistry. AbstractText: The low incidence of oesophageal adenocarcinoma (EAC) in Barrett's oesophagus (BE) patients reinforces the need for risk stratification tools to make BE surveillance more effective. Therefore, we have undertaken a systematic review and meta-analysis of published studies on immunohistochemical (IHC) biomarkers in BE to determine the ...
Esophageal Neoplasms (1), Barrett Esophagus (1), Adenocarcinoma (1), more mentions
DescriptorName: Combined Modality Therapy. DescriptorName: Disease-Free Survival. DescriptorName: EsophagealNeoplasms... AbstractText: Reports are limited regarding clinical and pretreatment features that might predict a pathological complete response (pathCR) after treatment in patients with esophagealcancer (EC... 2017 American Cancer Society Keyword: esophagealcancer. Keyword: neoadjuvant. Keyword: pathological complete response. Keyword: remission.
... have yet to assess the impact of ARB use on gastro-oesophagealcancer survival AbstractText: To investigate the association between post-diagnosis ARB use and gastro-oesophagealcancer survival AbstractText: We selected a cohort of patients with newly-diagnosed gastro-oesophagealcancer between 1998 and 2012 from English cancer registries ...
BACKGROUND: Percutaneous or surgical ablation are increasingly used worldwide in the management of atrial fibrillation. The development of atrioesophageal fistula (AEF) is among the most serious and lethal complications of atrial fibrillation ablation. We sought to characterize the clinical presentation, procedural characteristics, diagnostic investigations, and treatment outcomes of all reported cases of AEF.
METHODS AND RESULTS: Electronic searches were conducted in PubMed and Embase for English scientific literature articles. Out of 628 references, 120 cases of AEF were identified using various ablation modalities. Clinical presentation occurred between 0 and 60 days postablation (median 21 days). Fever (73%), neurological (72%), gastrointestinal (41%), and cardiac (40%) symptoms were the commonest presentations. Computed tomography of the chest was the commonest mode of diagnosis (68%), although 7 cases required repeat testing. Overall mortality was 55%, with significantly reduced mortality in patients undergoing surgical repair (33%) compared with endoscopic treatment (65%) and conservative management (97%) (adjusted odds ratio, 24.9; P<0.01, compared with surgery). Multivariable predictors of mortality include presentation with neurological symptoms (adjusted odds ratio, 16.0; P<0.001) and gastrointestinal bleed (adjusted odds ratio, 4.2; P=0.047).
CONCLUSIONS: AEF complicating atrial fibrillation ablation is associated with a high mortality. Clinicians should have a high suspicion for the development of AEF in patients presenting with infective, neurological, gastrointestinal, or cardiac symptoms within 2 months of an atrial fibrillation ablation. Investigation by contrast computed tomography of the chest with consideration of repeat testing can lead to prompt diagnosis. Surgical intervention is associated with improved survival rates.
DescriptorName: EsophagealNeoplasms... AbstractText: Palliative treatments and stents are necessary for relieving dysphagia in patients with esophagealcancer. The aim of this study was to simultaneously compare available treatments in terms of complications AbstractText: Web of Science, Medline, Scopus, Cochrane Library and Embase were searched. Statistical heterogeneity was assessed using the Chi2 test and was quantified by I2.
DescriptorName: EsophagealNeoplasms... AbstractText: Esophageal stenting is often considered to relieve dysphagia in patients with locoregionally advanced esophagealcancer... oncologic outcomes in patients undergoing chemoradiation therapy (CRT) AbstractText: The data from patients treated with curative intent CRT for locoregionally advanced esophagealcancer at the University of Utah were retrospectively analyzed.
Esophageal perforation due to blunt trauma is a rare clinical condition, and the diagnosis is often difficult because patients have few specific symptoms. Delayed diagnosis may result in a fatal clinical course due to mediastinitis and subsequent sepsis. In this article, we describe a 26-year-old man with esophageal perforation due to blunt chest trauma resulting from a motor vehicle accident. Because a severe disturbance of consciousness masked the patient's trauma-induced thoracic symptoms, we required 11h to diagnose the esophageal perforation. Therefore, the patient developed septic shock due to mediastinitis. However, his subsequent clinical course was good because of prompt combined therapy involving surgical repair and medical treatment after the diagnosis.
Esophageal Perforation (6), Mediastinitis (4), Coma (2), more mentions
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AbstractText: Please see Appendix 4 for a glossary of terms.The outcome of patients with esophagealcancer is generally poor. Although multimodal therapy is standard, there is conflicting evidence regarding the addition of esophagectomy to chemoradiotherapy AbstractText: To compare the effectiveness and safety of chemoradiotherapy plus surgery with that of chemoradiotherapy alone in people with nonmetastatic esophageal carcinoma AbstractText: We ...
DescriptorName: Databases, Factual. DescriptorName: EsophagealNeoplasms... The synergistically increased cancer risk between excessive amount of alcohol consumption and currently smoking or underweight individuals was observed only in the esophagealcancers AbstractText: Light drinking including even one alcoholic drink a day is associated with increased risks of esophageal, gastric and colorectal cancer.
Oncology (6), Endocrine Disorders (1), Anti-Obesity and Weight Loss (1) Colorectal Neoplasms (5), Stomach Neoplasms (2), Esophageal Neoplasms (1), more mentions
DescriptorName: Aged. DescriptorName: Digestive System Surgical Procedures. DescriptorName: EsophagealNeoplasms. DescriptorName: Female. DescriptorName: Hospitals, High-Volume. DescriptorName: Hospitals, Low-Volume. DescriptorName: Humans. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Outcome Assessment (Health Care. DescriptorName: Stomach Neoplasms. AbstractText: Most studies showing a volume outcome effect in resection surgery for oesophago-gastric cancer were conducted before the centralisation of clinical services.
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Adrenal Cortex Hormones. DescriptorName: Behcet Syndrome. DescriptorName: EsophagealDiseases. DescriptorName: Humans. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Rare Diseases. DescriptorName: Treatment Outcome. DescriptorName: Ulcer. AbstractText: The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ...
DescriptorName: Proton Pump Inhibitors. DescriptorName: Vitamin D. AbstractText: Vitamin D deficiency may increase esophagealcancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE.
Oncology (1) Barrett Esophagus (3), Esophageal Neoplasms (1), Vitamin D Deficiency (1), more mentions
Abstract: Oesophagealcancer is an aggressive disease... the last decade to evaluate whether and in which cases PETint may offer predictive potential in oesophagealcancer... uniform protocols and methods of analysis to assess the predictive and prognostic value of PETint in oesophagealcancer Keyword: Ad-interim FDG-PET... Keyword: Oesophagealcancer.
... survival but has not been extensively studied in locally-advanced oesophagealcancer treated with definitive chemoradiotherapy (dCRT... be an independent prognostic biomarker for OS and PFS in oesophagealcancer patients treated with definitive CRT... risk-stratification and should be considered for use in future oesophagealcancer clinical trials... Keyword: Oesophagealcancer.