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Esophageal Disease
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Your search returned 70 results
from the time period: last 90 days.
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Medicine
DescriptorName: Esophageal Neoplasms... of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery.Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery ... not been well investigated.This study included 539 patients with esophageal cancer undergoing surgery at 1 of 7 university hospitals... can reduce the risk of postoperative pneumonia in patients undergoing esophageal cancer surgery.
Oncology (5)
Pneumonia (10), Esophageal Neoplasms (6), Deglutition Disorders (2), more mentions
The British journal of surgery
DescriptorName: Esophageal Neoplasms... AbstractText: Since 2003, care for patients with oesophageal cancer has been centralized in a few dedicated centres in Denmark ... registered in a nationwide database AbstractText: All patients diagnosed with oesophageal cancer or cancer of the gastro-oesophageal junction who underwent oesophagectomy ... of quality of care have improved since the centralization of oesophageal cancer treatment in Denmark.
Oncology (5)
Neoplasms (5), Anastomotic Leak (2), Carcinoma (2), more mentions
Medicine
CitationSubset: IM. DescriptorName: Esophageal Neoplasms... AbstractText: Esophageal cancer (EC) is a common cancer with high mortality because of its rapid progression and poor prognosis. Radiotherapy is one of the most effective treatments for EC. Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) are 2 recently developed radiotherapy techniques.
Oncology (3)
Esophageal Neoplasms (3), Radiation Pneumonitis (2), Esophagitis (2), more mentions
The British journal of surgery 
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Aged. DescriptorName: Counseling. DescriptorName: Esophageal Neoplasms. DescriptorName: Esophagectomy. DescriptorName: Female. DescriptorName: Humans. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Postoperative Complications. DescriptorName: Quality of Life. DescriptorName: Sleep Wake Disorders. DescriptorName: Treatment Outcome. AbstractText: Major surgery such as oesophagectomy requires a postoperative stay in intensive care. Painful stimuli lead to sleep disturbance and impairment in quality of ...
Oncology (2)
Neoplasms (2), Esophageal Neoplasms (1), more mentions
International journal of radiation oncology, biology, physics
DescriptorName: Esophageal Neoplasms... AbstractText: Host immunity may affect the outcome in patients with esophageal cancer. We sought to identify factors that influenced absolute lymphocyte count (ALC) nadir during chemoradiation therapy (CRT) for esophageal cancer (EC) and looked for clinically relevant associations with survival AbstractText: 504 patients with stage I-III EC ...
Oncology (3)
Esophageal Neoplasms (4), Lymphopenia (2), Adenocarcinoma (1), more mentions
Clinical oncology (Royal College of Radiologists (Great Britain))
AbstractText: Treatment decision making and planning in patients with oesophageal cancer are guided by radiological measurement of length of disease (LoD... These results highlight the continued benefit of EUS in the oesophageal cancer staging and treatment pathway Keyword: Decision making. Keyword: endosonography. Keyword: oesophagus. Keyword: positron emission tomography. Keyword: radiotherapy.
Oncology (3)
Neoplasms (3), Adenocarcinoma (1), more mentions
7. Oesophageal cancer.  
Date: 06/26/2017
Lancet (London, England)
Abstract: Oesophageal cancer is a clinically challenging disease that requires a multidisciplinary approach... Neoadjuvant therapy with chemotherapy or chemoradiotherapy has supplemented surgery as standard treatment of locally advanced oesophageal cancer... This Seminar aims to provide insights into the current clinical management, ongoing controversies, and future needs in oesophageal cancer.
Oncology (4)
Neoplasms (4), more mentions
Medicine
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Endoscopic Mucosal Resection. DescriptorName: Esophageal Mucosa. DescriptorName: Esophageal Neoplasms. DescriptorName: Female. DescriptorName: Humans. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Multivariate Analysis. DescriptorName: Retrospective Studies. DescriptorName: Treatment Outcome. DescriptorName: Tumor Burden. Abstract: Because an esophageal submucosa tumor (SMT) may be malignant despite its small size, a safe endoscopic resection method is needed in some small SMTs.
Neoplasms (5), Granular Cell Tumor (1), Leiomyoma (1), more mentions
The British journal of surgery
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Adenocarcinoma. DescriptorName: Adult. DescriptorName: Aged. DescriptorName: Aged, 80 and over. DescriptorName: Biomarkers, Tumor. DescriptorName: Esophageal Neoplasms. DescriptorName: Esophagectomy. DescriptorName: Female. DescriptorName: Gene Expression. DescriptorName: Humans. DescriptorName: Immunohistochemistry. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Neoplasm Staging. DescriptorName: Prognosis. DescriptorName: SOXB1 Transcription Factors. AbstractText: Oesophageal adenocarcinoma (OAC) is a highly aggressive malignancy with poor survival, which is ...
Oncology (1)
Adenocarcinoma (4), Neoplasms (2), Esophageal Neoplasms (1), more mentions
The Cochrane database of systematic reviews 
AbstractText: Please see Appendix 4 for a glossary of terms.The outcome of patients with esophageal cancer is generally poor. Although multimodal therapy is standard, there is conflicting evidence regarding the addition of esophagectomy to chemoradiotherapy AbstractText: To compare the effectiveness and safety of chemoradiotherapy plus surgery with that of chemoradiotherapy alone in people with nonmetastatic esophageal carcinoma AbstractText: We ...
Oncology (2)
Deglutition Disorders (3), Carcinoma (3), Esophageal Neoplasms (2), more mentions
Medicine
CitationSubset: IM. DescriptorName: Adenocarcinoma. DescriptorName: Adult. DescriptorName: Aged. DescriptorName: Aged, 80 and over. DescriptorName: Area Under Curve. DescriptorName: Biomarkers, Tumor. DescriptorName: Body Mass Index. DescriptorName: Esophageal Neoplasms. DescriptorName: Esophagogastric Junction. DescriptorName: Female. DescriptorName: Follow-Up Studies. DescriptorName: Humans. DescriptorName: Kaplan-Meier Estimate. DescriptorName: Lymphocyte Count. DescriptorName: Male. DescriptorName: Middle Aged.
Anti-Obesity and Weight Loss (2), Oncology (2)
Neoplasms (3), Adenocarcinoma (3), Esophageal Neoplasms (1), more mentions
Human genetics
DescriptorName: Esophageal Neoplasms... Interestingly, we observed consistent associations between rs3747093 and multiple cancers (gastric cancer: OR = 0.85, P = 2.21 × 10(-4); esophageal cancer: OR = 0.91, P = 2.57 × 10(-2); colorectal cancer: OR = 0.80, P = 1.85 × 10(-6); and breast cancer: OR = 0.87, P = 1.55 × 10(-3. Taken together, the A allele of rs3747093 showed significant protective effects on cancer risk ...
Oncology (14)
Neoplasms (8), Lung Neoplasms (4), Colorectal Neoplasms (2), more mentions
Medicine
The aim of this study was to translate and cross-culturally adapt the swallowing quality-of-life questionnaire (SWAL-QOL) to Persian language and to determine validity and reliability of the Persian version of the swallow quality-of-life questionnaire (PSWAL-QOL) in the patients with oropharyngeal dysphagia.The cross-sectional survey was designed to translate and cross-culturally adapt SWAL-QOL to Persian language following steps recommended in guideline. A total of 142 patients with dysphagia (mean age = 56.7 ± 12.22 years) were selected by non-probability consecutive sampling method to evaluate construct validity and internal consistency. Thirty patients with dysphagia were completed the PSWAL-QOL 2 weeks later for test-retest reliability.The PSWAL-QOL was favorably accepted with no missing items. The floor effect was ranged 0% to 21% and ceiling effect was ranged 0% to 16%. The construct validity was established via exploratory factor analysis. Internal consistency was confirmed with Cronbach α >0.7 for all scales except eating duration (α = 0.68). The test-retest reliability was excellent with intraclass correlation coefficient (ICC) ≥0.75 for all scales.The SWAL-QOL was cross-culturally adapted to Persian and demonstrated to be a valid and reliable self-report questionnaire to measure the impact of dysphagia on the quality-of-life in the Persian patients with oropharyngeal dysphagia.
Deglutition Disorders (4), Oropharyngeal Dysphagia (2), more mentions
PloS one
DescriptorName: Adult. DescriptorName: Aged. DescriptorName: Biomarkers, Tumor. DescriptorName: Carcinoma, Squamous Cell. DescriptorName: Esophageal Neoplasms. DescriptorName: Esophagectomy. DescriptorName: Female. DescriptorName: Hemoglobins. DescriptorName: Humans. DescriptorName: Kaplan-Meier Estimate. DescriptorName: Lymphatic Metastasis. DescriptorName: Male. DescriptorName: Middle Aged. DescriptorName: Prognosis. DescriptorName: Retroperitoneal Neoplasms. DescriptorName: Retrospective Studies. AbstractText: Patients with inoperable esophageal squamous cell carcinoma (ESCC) were not homogeneous and their outcomes were widely divergent.
Oncology (3)
Squamous Cell Carcinoma (2), Neoplasms (2), Esophageal Neoplasms (1), more mentions
Medicine
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Carcinoma, Squamous Cell. DescriptorName: Esophageal Neoplasms. DescriptorName: Humans. DescriptorName: Microvessels. DescriptorName: Prognosis. AbstractText: To date, literature has emerged that shows contradictory results about the prognostic role of microvessel density (MVD) in esophageal squamous cell cancer (ESCC. The aim of the study set out to evaluate the correlation between MVD and the prognosis of ESCC AbstractText ...
Oncology (2)
Squamous Cell Neoplasms (2), Esophageal Neoplasms (1), Carcinoma (1), more mentions
Medicine
CitationSubset: AIM. CitationSubset: IM. DescriptorName: Carcinoma. DescriptorName: Esophageal Neoplasms. DescriptorName: Humans. DescriptorName: Lymphatic Metastasis. DescriptorName: Neoadjuvant Therapy. DescriptorName: Prognosis. AbstractText: The aim of this study was to evaluate the outcomes of patients with pathologic T0 esophageal carcinoma after neoadjuvant therapy and surgery AbstractText: We searched PubMed, Embase, Cochrane Library, and Medline databases from inception up to November 12, 2016.
Oncology (1)
Carcinoma (4), Lymphatic Metastasis (1), Esophageal Neoplasms (1), more mentions
The Journal of bone and joint surgery. American volume
BACKGROUND: Although dysphagia is a common complication after anterior cervical decompression and fusion, important risk factors have not been rigorously evaluated. Furthermore, the impact of dysphagia on neurological and quality-of-life outcomes is not fully understood. The aim of this study was to determine the prevalence of and risk factors for dysphagia, and the impact of this complication on short and long-term clinical outcomes, in patients treated with anterior cervical decompression and fusion. METHODS: Four hundred and seventy patients undergoing a 1-stage anterior or 2-stage anteroposterior cervical decompression and fusion were enrolled in the prospective AOSpine CSM (Cervical Spondylotic Myelopathy) North America or International study at 26 global sites. Logistic regression analyses were conducted to determine important clinical and surgical predictors of perioperative dysphagia. Preoperatively and at each follow-up visit, patients were evaluated using the modified Japanese Orthopaedic Association scale (mJOA), Nurick score, Neck Disability Index (NDI), and Short Form-36 Health Survey (SF-36). A 2-way repeated-measures analysis of covariance was used to evaluate differences in outcomes at 6 and 24 months between patients with and those without dysphagia, while controlling for relevant baseline characteristics and surgical factors. RESULTS: The overall prevalence of dysphagia was 6.2%. Bivariate analysis showed the major risk factors for perioperative dysphagia to be a higher comorbidity score, older age, a cardiovascular or endocrine disorder, a lower SF-36 Physical Component Summary score, 2-stage surgery, and a greater number of decompressed levels. Multivariable analysis showed patients to be at an increased risk of perioperative dysphagia if they had an endocrine disorder, a greater number of decompressed segments, or 2-stage surgery. Both short and long-term improvements in functional, disability, and quality-of-life scores were comparable between patients with and those without dysphagia. CONCLUSIONS: The most important predictors of dysphagia are an endocrine disorder, a greater number of decompressed levels, and 2-stage surgery. At the time of both short and long-term follow-up, patients with perioperative dysphagia exhibited improvements in functional, disability, and quality-of life scores that were similar to those of patients without dysphagia. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Deglutition Disorders (14), Spinal Cord Diseases (2), Spondylosis (1), more mentions
Medicine
A multicenter retrospective study.The purpose of this study was to explore risk factors of dysphagia after anterior cervical surgery and factors affecting rehabilitation of dysphagia 2 years after surgery.Patients who underwent anterior cervical surgery at 3 centers from January 2010 to January 2013 were included. The possible factors included 3 aspects: demographic variables-age, sex, body mass index (BMI): hypertension, diabetes, heart disease, smoking, alcohol use, diagnose (cervical spondylotic myelopathy or ossification of posterior longitudinal ligament), preoperative visual analogue scale (VAS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA), surgical-related variables-surgical option (ACDF, ACCF, ACCDF, or Zero profile), operation time, blood loss, operative level, superior fusion segment, incision length, angle of C2 to C7, height of C2 to C7, cervical circumference, cervical circumference/height of C2 to C7.The results of our study indicated that the rate of dysphagia at 0, 3, 6, 12, and 24 months after surgery was 20%, 5.4%, 2.4%, 1.1%, and 0.4%, respectively. Our results showed that age (58.8 years old), BMI (27.3 kg/m), course of disease (11.6 months), operation time (103.2 min), blood loss (151.6 mL), incision length (9.1 cm), cervical circumference (46.8 cm), angle of C2 to C7 (15.3°), cervical circumference/height of C2 to C7 (4.8), preoperative VAS (7.5), and ODI (0.6) in dysphagia group were significantly higher than those (52.0, 24.6, 8.6, 88.2, 121.6, 8.6, 42.3, 12.6, 3.7, 5.6, and 0.4, respectively) in nondysphagia group; however, height of C2 to C7 (9.9 vs 11.7 cm) and preoperative JOA (8.3 vs 10.7) had opposite trend between 2 groups. We could also infer that female, smoking, diabetes, ossification of posterior longitudinal ligament, ACCDF, multilevel surgery, and superior fusion segment including C2 to C3 or C6 to C7 were the risk factors for dysphagia after surgery immediately. However, till 2 years after surgery, only 2 risk factors, smoking and diabetes, could slow rehabilitation of dysphagia.Many factors could significantly increase rate of dysphagia after anterior cervical surgery. Operation time as a vital factor markedly increases immediate postoperative dysphagia and smoking, as the most important factor, lower recovery of dysphagia. Further study is needed to prove if these factors could influence dysphagia.
Endocrine Disorders (4), Cardiovascular Diseases (3), Anti-Obesity and Weight Loss (2)
Deglutition Disorders (12), Diabetes Mellitus (4), Ossification of Posterior Longitudinal Ligament (2), more mentions
International journal of radiation oncology, biology, physics
PURPOSE/OBJECTIVE(S): To estimate the association between different dose-volume metrics of the salivary glands and pharyngeal constrictors with patient reported severity of xerostomia/dysphagia in the setting of deintensified chemoradiation therapy (CRT). METHODS AND MATERIALS: Forty-five patients were treated on a phase 2 study assessing the efficacy of deintensified CRT for favorable-risk, HPV-associated oropharyngeal squamous cell carcinoma. Patients received 60 Gy intensity modulated radiation therapy with concurrent weekly cisplatin (30 mg/m(2)), and reported the severity of their xerostomia/dysphagia (before and after treatment) using the patient-reported outcome version of the Common Terminology Criteria for Adverse Events (CTCAE) (PRO-CTCAE). Individual patient dosimetric data of the contralateral parotid and submandibular glands and pharyngeal constrictors were correlated with changes in PRO-CTCAE severity. A change in severity (from baseline) of ≥2 was considered clinically meaningful. Associations between dose-volume metrics and patient outcomes were assessed with receiver operating characteristic (ROC) curve and logistic regression model. RESULTS: Six months after CRT, patients reporting <2 change in xerostomia severity (n=14) had an average Dmean = 22 ± 9 Gy to the sum of the contralateral glands (parotid + submandibular) compared with the patients reporting ≥2 change (n=21), who had an average Dmean = 34 ± 8 Gy. V15 to V55 for the combined contralateral glands showed the strongest association with xerostomia (area under the curve [AUC] = 0.83-0.86). Based on the regression analysis, a 20% risk of toxicity was associated with V15 = 48%, V25 = 30%, and Dmean=21 Gy. Six months after CRT, patients reporting <2 change in dysphagia severity (n=26) had an average V55 = 76 ± 13 (%) to the superior pharyngeal constrictor compared with the patients reporting ≥2 change in severity (n=9), who had average V55 = 89 ± 13 (%). V55to V60 had the strongest association with dysphagia (AUC = 0.70-0.75). Based on the regression analysis, a 20% risk of toxicity was associated with V55 = 78%, V60 = 40%. The findings at 12 months were similar. CONCLUSIONS: After deintensified CRT, the rate of patient-reported xerostomia/dysphagia appears to be associated with the V15 of the combined contralateral salivary glands and V55 to V60 of the superior pharyngeal constrictors.
Xerostomia (7), Deglutition Disorders (7), Squamous Cell Carcinoma (2), more mentions
JAMA oncology
Is There Merit for MET-Targeted Therapies in Gastroesophageal Cancer?.
Oncology (2)
Neoplasms (2), more mentions
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