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Acute Liver Failure
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Acute Liver Failure is the relatively rapid development of coagulopathy and encephalopathy in the absence of preexisting liver disease; its etiologies are diverse and intensive monitoring is critical, as is timely referral for evaluation of liver transplantation. From the Washington Manual of Gastroenterology Subspecialty.

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The New England journal of medicine
CitationSubset: IM. DescriptorName: Aged. DescriptorName: Bacteremia. DescriptorName: Blood Culture. DescriptorName: Campylobacter Infections. DescriptorName: Campylobacter jejuni. DescriptorName: Delirium. DescriptorName: Diagnosis, Differential. DescriptorName: Fatal Outcome. DescriptorName: Female. DescriptorName: Heart Failure. DescriptorName: Hepatitis, Autoimmune. DescriptorName: Humans. DescriptorName: Immunocompromised Host. DescriptorName: Jaundice. DescriptorName: Liver Failure, Acute. DescriptorName: Liver Function Tests. DescriptorName: Lung. DescriptorName: Radiography.
Infectious Diseases (1), Immune System Diseases (1)
Bacteremia (2), Campylobacter Infections (1), Heart Failure (1), more mentions
Journal of gastroenterology
AbstractText: A nationwide survey was performed to clarify the recent status of acute liver failure (ALF) and late-onset hepatic failure (LOHF) in Japan AbstractText: Two-step surveys for patients with ALF and LOHF ... have changed, the outcomes of patients have not improved in recent years Keyword: Acute liver failure.
Infectious Diseases (6), Immune System Diseases (1)
Coma (6), Acute Liver Failure (3), Hepatitis (3), more mentions
The American journal of gastroenterology
OBJECTIVES: In patients with cirrhosis, infections represent a frequent trigger for complications, increasing frequency of hospitalizations and mortality rate. This study aimed to identify predictors of early readmission (30 days) and of mid-term mortality (6 months) in patients with liver cirrhosis discharged after a hospitalization for bacterial and/or fungal infection. METHODS: A total of 199 patients with cirrhosis discharged after an admission for a bacterial and/or fungal infection were included in the study and followed up for a least 6 months. RESULTS: During follow-up, 69 patients (35%) were readmitted within 30 days from discharge. C-reactive protein (CRP) value at discharge (odds ratio (OR)=1.91; P=0.022), diagnosis of acute-on-chronic liver failure during the hospital stay (OR=2.48; P=0.008), and the hospitalization in the last 30 days previous to the admission/inclusion in the study (OR=1.50; P=0.042) were found to be independent predictors of readmission. During the 6-month follow-up, 47 patients (23%) died. Age (hazard ratio (HR)=1.05; P=0.001), model of end-stage liver disease (MELD) score (HR=1.13; P<0.001), CRP (HR=1.85; P=0.001), refractory ascites (HR=2.22; P=0.007), and diabetes (HR=2.41; P=0.010) were found to be independent predictors of 6-month mortality. Patients with a CRP >10 mg/l at discharge had a significantly higher probability of being readmitted within 30 days (44% vs. 24%; P=0.007) and a significantly lower probability of 6-month survival (62% vs. 88%; P<0.001) than those with a CRP ≤10 mg/l. CONCLUSIONS: CRP showed to be a strong predictor of early hospital readmission and 6-month mortality in patients with cirrhosis after hospitalization for bacterial and/or fungal infection. CRP values could be used both in the stewardship of antibiotic treatment and to identify fragile patients who deserve a strict surveillance program.
Infectious Diseases (3)
Cirrhosis (4), Infections (4), Chronic Liver Failure (2), more mentions
Few cases of hepatitis A virus (HAV)-associated acute liver failure (ALF) have been reported in low HAV endemic countries annually AbstractText: To investigate the possible factors that affected the severity of HAV infection, a family cluster infected with the HAV subgenotype IB strain, which is not common in Japan ...
Infectious Diseases (6)
Hepatitis A (5), Liver Failure (3), Infections (2), more mentions
Clinical transplantation
Abstract: Hepatitis A virus (HAV) can cause acute liver failure (ALF... All rights reserved Keyword: Acute Liver Failure. Keyword: Hepatitis A. Keyword: Hepatitis B. Keyword: Liver Transplantation.
Infectious Diseases (6)
Acute Liver Failure (3), Hepatitis A (2), Hepatitis B (2), more mentions
Scandinavian journal of gastroenterology
AbstractText: Infections are common and associated with complications and mortality in acute liver failure (ALF. The temporal relationship between ammonia and infection in ALF patients is unclear. We aimed to evaluate the predictors of infection and its relationship with arterial ammonia levels AbstractText: Consecutive ALF patients hospitalized between January 2004 and December 2015, without signs of infection at/within 48 ...
Infectious Diseases (2)
Infections (11), Cerebral Edema (2), Acute Liver Failure (2), more mentions
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Viruses Associated with Unexplained Acute Liver Failure: Next Generation Reveals the Last Generation..
Acute Liver Failure (2), more mentions
Liver international : official journal of the International Association for the Study of the Liver
I read with great interest the study performed by Anastasiou and colleagues. They performed an excellent retrospective study, with an expressive number of patients with acute liver failure(ALF. They investigated if serum ferritin and transferrin could predict outcome in ALF. The patients were separated in spontaneous recovery(SR) and non-spontaneous recovery group(NSR.
Acute Liver Failure (2), more mentions
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
AbstractText: Twelve percent of all acute liver failure (ALF) cases are of unknown origin, often termed indeterminate. A previously unrecognized hepatotropic virus has been suspected as a potential etiologic agent AbstractText: We compared the performance of metagenomic next-generation sequencing (mNGS) with confirmatory nucleic acid testing (NAT) to routine clinical diagnostic testing in detection of known or novel viruses associated ...
Infectious Diseases (4)
Infections (3), Coinfections (2), Acute Liver Failure (2), more mentions
Hepatology (Baltimore, Md.)
AbstractText: Hyperammonemia has been associated with intracranial hypertension and mortality in patients with acute liver failure (ALF. We evaluated the effect of renal replacement therapy (RRT) on serum ammonia level and outcomes in ALF AbstractText: Multicenter cohort study of consecutive ALF patients from the United States ALF Study Group registry between 01/1998-12/2016.
Cardiovascular Diseases (1)
Hyperammonemia (2), Acute Liver Failure (2), Intracranial Hypertension (1), more mentions
Journal of hepatology
Acute liver failure: Does the EASL guidelines address the whole spectrum?.
Acute Liver Failure (2), more mentions
Hepatology (Baltimore, Md.)
Should venous ammonia be used in decision making acute liver failure patients?.
Acute Liver Failure (2), more mentions
Hepatology (Baltimore, Md.)
Reply to: "Should venous ammonia be used in decision making acute liver failure patients?".
Acute Liver Failure (2), more mentions
Journal of intensive care medicine
Abstract: Acute liver failure secondary to acetaminophen overdose can be a life-threatening condition, characterized by severe electrolyte derangements... We report the case of profound, life-threatening hypophosphatemia following recovery from acute fulminant liver failure. As the liver enzymes normalized, serum phosphorous levels plummeted. Our patient required an aggressive, individualized phosphorus replacement regimen, which resulted in a continuous infusion of ...
Hypophosphatemia (4), Acute Liver Failure (3), Liver Failure (1), more mentions
Hepatology (Baltimore, Md.)
Extracellular vesicles as novel therapeutics in hepatic failure..
Liver Failure (2), more mentions
Alimentary pharmacology & therapeutics
... who received HCV treatment and all incident cases of cirrhosis, hepatic decompensation and hepatocellular carcinoma... exposure was also independently associated with an increased risk of hepatic decompensation (HR: 3.79 [2.58, 5.57]) and hepatocellular carcinoma (HR: 2.01 [1.50 ... disease to cirrhosis, as well as an increased risk of hepatic decompensation and hepatocellular carcinoma.
Infectious Diseases (2)
Cirrhosis (6), Hepatocellular Carcinoma (4), Liver Diseases (3), more mentions
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Antiviral resistance emerged in five patients treated with LAM by 48 weeks (17.9%, P=0.003) AbstractText: LAM, ETV, and TDF selection is not related with mortality and LT in patients with severe acute CHB exacerbation and hepatic decompensation. To reduce mortality, patients with ascites and MELD scores above 25 should be considered for LT Keyword: Acute exacerbation.
Infectious Diseases (3), Immune System Diseases (1)
Chronic Hepatitis B (3), Ascites (2), Liver Diseases (1), more mentions