AbstractText: A nationwide survey was performed to clarify the recent status of acuteliverfailure (ALF) and late-onset hepaticfailure (LOHF) in Japan AbstractText: Two-step surveys for patients with ALF and LOHF ... have changed, the outcomes of patients have not improved in recent years Keyword: Acuteliverfailure.
Infectious Diseases (6), Immune System Diseases (1) Coma (6), Acute Liver Failure (3), Hepatitis (3), more mentions
OBJECTIVES: In patients with cirrhosis, infections represent a frequent trigger for complications, increasing frequency of hospitalizations and mortality rate. This study aimed to identify predictors of early readmission (30 days) and of mid-term mortality (6 months) in patients with liver cirrhosis discharged after a hospitalization for bacterial and/or fungal infection.
METHODS: A total of 199 patients with cirrhosis discharged after an admission for a bacterial and/or fungal infection were included in the study and followed up for a least 6 months.
RESULTS: During follow-up, 69 patients (35%) were readmitted within 30 days from discharge. C-reactive protein (CRP) value at discharge (odds ratio (OR)=1.91; P=0.022), diagnosis of acute-on-chronic liver failure during the hospital stay (OR=2.48; P=0.008), and the hospitalization in the last 30 days previous to the admission/inclusion in the study (OR=1.50; P=0.042) were found to be independent predictors of readmission. During the 6-month follow-up, 47 patients (23%) died. Age (hazard ratio (HR)=1.05; P=0.001), model of end-stage liver disease (MELD) score (HR=1.13; P<0.001), CRP (HR=1.85; P=0.001), refractory ascites (HR=2.22; P=0.007), and diabetes (HR=2.41; P=0.010) were found to be independent predictors of 6-month mortality. Patients with a CRP >10 mg/l at discharge had a significantly higher probability of being readmitted within 30 days (44% vs. 24%; P=0.007) and a significantly lower probability of 6-month survival (62% vs. 88%; P<0.001) than those with a CRP ≤10 mg/l.
CONCLUSIONS: CRP showed to be a strong predictor of early hospital readmission and 6-month mortality in patients with cirrhosis after hospitalization for bacterial and/or fungal infection. CRP values could be used both in the stewardship of antibiotic treatment and to identify fragile patients who deserve a strict surveillance program.
Few cases of hepatitis A virus (HAV)-associated acuteliverfailure (ALF) have been reported in low HAV endemic countries annually AbstractText: To investigate the possible factors that affected the severity of HAV infection, a family cluster infected with the HAV subgenotype IB strain, which is not common in Japan ...
Infectious Diseases (6) Hepatitis A (5), Liver Failure (3), Infections (2), more mentions
AbstractText: Infections are common and associated with complications and mortality in acuteliverfailure (ALF. The temporal relationship between ammonia and infection in ALF patients is unclear. We aimed to evaluate the predictors of infection and its relationship with arterial ammonia levels AbstractText: Consecutive ALF patients hospitalized between January 2004 and December 2015, without signs of infection at/within 48 ...
I read with great interest the study performed by Anastasiou and colleagues. They performed an excellent retrospective study, with an expressive number of patients with acuteliverfailure(ALF. They investigated if serum ferritin and transferrin could predict outcome in ALF. The patients were separated in spontaneous recovery(SR) and non-spontaneous recovery group(NSR.
AbstractText: Twelve percent of all acuteliverfailure (ALF) cases are of unknown origin, often termed indeterminate. A previously unrecognized hepatotropic virus has been suspected as a potential etiologic agent AbstractText: We compared the performance of metagenomic next-generation sequencing (mNGS) with confirmatory nucleic acid testing (NAT) to routine clinical diagnostic testing in detection of known or novel viruses associated ...
AbstractText: Hyperammonemia has been associated with intracranial hypertension and mortality in patients with acuteliverfailure (ALF. We evaluated the effect of renal replacement therapy (RRT) on serum ammonia level and outcomes in ALF AbstractText: Multicenter cohort study of consecutive ALF patients from the United States ALF Study Group registry between 01/1998-12/2016.
Abstract: Acuteliverfailure secondary to acetaminophen overdose can be a life-threatening condition, characterized by severe electrolyte derangements... We report the case of profound, life-threatening hypophosphatemia following recovery from acute fulminantliverfailure. As the liver enzymes normalized, serum phosphorous levels plummeted. Our patient required an aggressive, individualized phosphorus replacement regimen, which resulted in a continuous infusion of ...
... who received HCV treatment and all incident cases of cirrhosis, hepaticdecompensation and hepatocellular carcinoma... exposure was also independently associated with an increased risk of hepaticdecompensation (HR: 3.79 [2.58, 5.57]) and hepatocellular carcinoma (HR: 2.01 [1.50 ... disease to cirrhosis, as well as an increased risk of hepaticdecompensation and hepatocellular carcinoma.
Antiviral resistance emerged in five patients treated with LAM by 48 weeks (17.9%, P=0.003) AbstractText: LAM, ETV, and TDF selection is not related with mortality and LT in patients with severe acute CHB exacerbation and hepaticdecompensation. To reduce mortality, patients with ascites and MELD scores above 25 should be considered for LT Keyword: Acute exacerbation.
Infectious Diseases (3), Immune System Diseases (1) Chronic Hepatitis B (3), Ascites (2), Liver Diseases (1), more mentions