We present a case of cerebellar dysfunction due to severe hypothyroidism induced by pembrolizumab, a member of the 'immune checkpoint inhibitor' class of cancer immunotherapies. Thyroxine replacement completely resolved his symptoms and signs. We also discuss the neurological immune-related complications of checkpoint inhibitors..
AbstractText: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs ... the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients AbstractText: A prospective, randomized, double-blind, single-center placebo ... ashwagandha may be beneficial for normalizing thyroid indices in subclinical hypothyroid patients Keyword: Withania somnifera (L.) Dunal.
... with low thyroid function were assigned to groups of subclinical hypothyroidism (plasma level of TSH above 4.5 mIU/L within a ... low thyroid function, a higher proportion of patients with subclinical hypothyroidism had NASH and associated advanced fibrosis vs patients with low ... plasma concentration of TSH (Ptrend <.05 for each) AbstractText: Subclinical hypothyroidism and low-normal thyroid function are independent predictors of NASH ...
... whereas TD was detected in 25.3 % and 9.4 % (p= 0.002), hypothyroidism was detected in 21.5 % and 6.9 % (p= 0.002), and hyperthyroidism ... Mild hypothyroidism was more frequent in the SLE patients with anti-Smith (anti-SM) antibodies (p= 0.029) AbstractText: Because hypothyroidism was more frequent in the SLE patients and because of ...
Immune System Diseases (6), Muscular and Skeletal Diseases (1) Hypothyroidism (5), Thyroid Diseases (2), Systemic Lupus Erythematosus (2), more mentions
... literature for comparison, reporting the prevalence of overt and subclinical hypothyroidism in the general US population and/or elderly US population ... The prevalence of hypothyroidism among the population of SCC patients was significantly greater than the prevalence of hypothyroidism (overt and subclinical) in any general and/or elderly US ... of skin are more likely to have a history of hypothyroidism than the general population.
... was to evaluate the association of thyroid cancer with primary hypothyroidism based on a population-based database... to examine the association of thyroid cancer with previously diagnosed hypothyroidism. We found that a prior hypothyroidism diagnosis was found among 37 cases (2.88%) and 33 controls ... cases were more likely to have been previously diagnosed with hypothyroidism than controls (adjusted OR, 3.01; 95%CI, 1.85-4.89.
Oncology (8) Hypothyroidism (9), Thyroid Carcinoma (7), Breast Neoplasms (1), more mentions
CeH is about 1000-folds rarer than Primary Hypothyroidism and often represents a real challenge for the clinicians, mainly because they cannot rely on adequately sensitive parameters for diagnosis or management ... This review provides an updated illustration of the different genetic defects accounting for CeH Keyword: central hypothyroidism... Keyword: hypothyroidism.
Studies suggest that subclinical hypothyroidism (SCH) is related to cardiovascular mortality (CVM... both SCH and MIA.Prevalence of MIA in the subclinical hypothyroid cohort was 21% compared to 16.4% in those without SCH ... adjusted hazard ratio = 1.72, 95% CI: 1.07-2.76) in subclinical hypothyroid individuals.In a cohort of subclinical hypothyroid individuals, the presence of MIA predicts increased risk of CVM ...
We report two patients with sagittal craniosynostosis, hypoplastic male genitalia, agenesis of the corpus callosum, thyroid abnormalities, and dysmorphic features which include short palpebral fissures and retrognathia. The clinical presentation of both patients was initially thought to be suggestive of Lin-Gettig syndrome (LGS), a multiple malformation syndrome associated with craniosynostosis that was initially reported in two brothers in 1990, with a third patient reported in 2003. Our first patient was subsequently found through exome sequencing to have a de novo mutation in KAT6B, c.4572dupT, p.(Thr1525Tyrfs*16). The second patient was ascertained as possible LGS, but KAT6B mutation testing was pursued clinically after the identification of the KAT6B mutation in Patient 1, and identified a de novo mutation, c.4205_4206delCT, p.(Ser1402Cysfs*5). The phenotypic spectrum of KAT6B mutations has been expanding since identification of KAT6B mutations in genitopatellar syndrome (GPS) and Say Barber Biesecker Young Simpson (SBBYS) syndrome patients. We show that craniosynostosis, which has not been previously reported in association with KAT6B mutations, may be part of the genitopatellar/Say Barber Biesecker Young Simpson spectrum. These two patients also further demonstrate the overlapping phenotypes of genitopatellar and SBBYS syndromes recently observed by others. Furthermore, we propose that it is possible that one or more of the previous cases of LGS may have also been due to mutation in KAT6B, and that LGS may actually be a variant within the KAT6B spectrum and not a distinct clinical entity.
Men's Health (1) Craniosynostoses (4), Retrognathia (1), more mentions
Although hypothyroidism is highly prevalent in hemodialysis patients, it is unknown whether thyroid status is a risk factor for impaired health-related quality of life or mental health in this population AbstractText: We examined the association of thyroid status, defined by serum thyrotropin, with health-related quality of ... Keyword: Hypothyroidism.
Neuroscience (1) Depressive Disorder (6), Hypothyroidism (2), more mentions
Abstract: Developmental anomalies of the thyroid gland, defined as thyroid dysgenesis, underlie the majority of cases of congenitalhypothyroidism... brief overview of the monogenic defects in candidate genes that have been identified so far and of the syndromes which are known to be associated with thyroid dysgenesis Keyword: congenitalhypothyroidism.
Abstract: Pendred syndrome is an autosomal recessive disorder that is classically defined by the combination of sensorineural deafness/hearing impairment, goiter, and an abnormal organification of iodide with or without hypothyroidism... Keyword: congenitalhypothyroidism. Keyword: goiter. Keyword: iodide. Keyword: sensorineural deafness. Keyword: thyroid hormone.