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Cystic Fibrosis
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Your search returned 41 results
from the time period: last 90 days.
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PloS one
DescriptorName: Autophagy. DescriptorName: Cystic Fibrosis. DescriptorName: Cystic Fibrosis Transmembrane Conductance Regulator... AbstractText: Cystic Fibrosis (CF) is a genetic disorder caused by mutation(s) in the CF-transmembrane conductance regulator (Cftr) gene. The most common mutation, ΔF508, leads to accumulation of defective-CFTR protein in aggresome-bodies. Additionally, Pseudomonas aeruginosa (Pa), a common CF pathogen, exacerbates obstructive CF lung pathology.
Cystic Fibrosis (4), Infections (2), Lung Diseases (1), more mentions
PloS one
DescriptorName: Cystic Fibrosis. DescriptorName: Cystic Fibrosis Transmembrane Conductance Regulator... Abstract: Cystic Fibrosis is an autosomal recessive disorder caused by mutations in the CFTR gene... Here, we describe a high efficiency strategy for editing of three different rare CFTR mutations which together account for about 3% of individuals with Cystic Fibrosis.
Cystic Fibrosis (5), more mentions
The New England journal of medicine 
Abstract: Background Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor ... to target the underlying cause of disease in patients with cystic fibrosis... in patients 12 years of age or older who had cystic fibrosis and were homozygous for the CFTR Phe508del mutation.
Cystic Fibrosis (5), more mentions
PloS one
DescriptorName: Cysteamine. DescriptorName: Cystic Fibrosis... Abstract: Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF. We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to defective autophagy, causing continued systemic inflammation and infection.
Infectious Diseases (2)
Cystic Fibrosis (3), Infections (1), more mentions
PloS one
DescriptorName: Cohort Studies. DescriptorName: Cystic Fibrosis... In cystic fibrosis (CF), an elevation of specific IgG4 has been associated with colonization and infection by Pseudomonas aeruginosa. IgG4 elevation may be a marker of chronic infection or inflammatory stimulation. The aim of this study was to explore the prevalence of elevated IgG4 levels in CF and its correlation with the major clinical ...
Cystic Fibrosis (3), Infections (2), Staphylococcal Infections (1), more mentions
Gastroenterology
AbstractText: Individuals with cystic fibrosis are at increased risk of colorectal cancer (CRC) compared to ... analysis to determine optimal CRC screening strategies for patients with cystic fibrosis AbstractText: We adjusted the existing MISCAN-Colon microsimulation model to ... increased CRC risk and lower life-expectancy in patients with cystic fibrosis... 40 years, was the optimal colonoscopy strategy for patients with cystic fibrosis who never received an organ transplant; this strategy prevented 79 ...
Oncology (9)
Cystic Fibrosis (10), Colorectal Neoplasms (3), more mentions
The New England journal of medicine 
CFTR Modulator Therapy for Cystic Fibrosis..
Cystic Fibrosis (2), more mentions
Chest
AbstractText: Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation... Keyword: cystic fibrosis. Keyword: ivacaftor. Keyword: low-dose chest CT imaging.
Cystic Fibrosis (3), more mentions
The Cochrane database of systematic reviews 
... that autogenic drainage is an effective intervention for people with cystic fibrosis AbstractText: To compare the clinical effectiveness of autogenic drainage in people with cystic fibrosis with other physiotherapy airway clearance techniques AbstractText: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of ... August 2017).Dtae of most recent search of the Cochrane Cystic Fibrosis Trials Register: 25 September 2017 AbstractText: We identified randomised and ...
Infectious Diseases (1)
Cystic Fibrosis (8), more mentions
American journal of respiratory and critical care medicine
AbstractText: The severity of cystic fibrosis (CF) lung disease varies widely, even for Phe508del homozygotes. Heritability studies show that >50% of the variability reflects non-CFTR genetic variation; however the full extent of the pertinent genetic variation is not known AbstractText: We sought to identify novel CF disease-modifying mechanisms using an integrated approach based on analyzing "in vivo" CF ...
Lung Diseases (5), Cystic Fibrosis (2), Infections (1), more mentions
Hepatology (Baltimore, Md.)
Reply: Cystic Fibrosis Liver Disease in Adults: limits of non-invasive tests of fibrosis..
Cystic Fibrosis (2), Liver Diseases (2), Fibrosis (2), more mentions
Hepatology (Baltimore, Md.)
Letter to the editors: Cystic fibrosis liver disease in adults: limits of non invasive tests of fibrosis..
Cystic Fibrosis (2), Liver Diseases (2), Fibrosis (2), more mentions
International journal of antimicrobial agents
First description of rpsJ and mepA mutations associated with tigecycline resistance in Staphylococcus aureus isolated from a cystic fibrosis patient during antibiotic therapy..
Infectious Diseases (2)
Cystic Fibrosis (2), more mentions
Thorax
Quantification of CT bronchiectasis and its relationship to ventilation in cystic fibrosis..
Cystic Fibrosis (2), Bronchiectasis (2), more mentions
Transplant infectious disease : an official journal of the Transplantation Society
A 35-year-old woman with severe cystic fibrosis was admitted for sudden loss of strength in both legs, revealing a myelitis. The medullar lesion biopsy revealed phaeohyphomycosis caused by Cladophialophora species. Myelitis caused by Cladophialophora bantiana is a rare disease associated with high mortality. This article is protected by copyright.
Cystic Fibrosis (2), Myelitis (2), Phaeohyphomycosis (1), more mentions
Endocrinology
CFTR: Ferreting Out Its Role in Cystic Fibrosis-Related Diabetes..
Endocrine Disorders (2)
Cystic Fibrosis (2), Diabetes Mellitus (2), more mentions
The Journal of antimicrobial chemotherapy
In this study we examine the impact of rifampicin on the AG susceptibility of cystic fibrosis (CF) lung isolates of P. aeruginosa and the contribution of AmgRS to AG resistance in these isolates.amgR deletion derivatives of clinical isolates were constructed using standard gene replacement technology. Susceptibility to AGs ± rifampicin (at ½ MIC) was assessed using a serial 2-fold ...
Cystic Fibrosis (2), more mentions
American journal of respiratory and critical care medicine
Genetic Variants and Altered Expression of non-CFTR Genes May Explain Differences in Cystic Fibrosis Severity..
Cystic Fibrosis (2), more mentions
American journal of respiratory and critical care medicine
People with cystic fibrosis (CF) generate Pseudomonas aeruginosa in droplet nuclei during coughing. The use of surgical masks has been recommended in healthcare settings to minimise pathogen transmission between CF patients.To determine if face masks and cough etiquette reduce viable P. aeruginosa aerosolised during cough.Twenty-five adults with CF and chronic P. aeruginosa infection were recruited.
Cough (11), Cystic Fibrosis (2), Infections (1), more mentions
The Lancet. Respiratory medicine
Clinical trial research in focus: ensuring new cystic fibrosis drugs fulfil their potential..
Cystic Fibrosis (2), more mentions
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