In this study we investigated the circadian pattern of Clock-related genes in patients with polyglandularautoimmunesyndrome type III (PAS type III) AbstractText: Nineteen patients diagnosed with PAS type III and 12 healthy controls were enrolled. mRNA and protein expression of Clock-related genes (CLOCK, BMAL1, ROR and Per-1,-2,-3), as well as the GR-a and ...
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DescriptorName: Candidiasis... controlled trials comparing any antifungal use versus placebo to prevent candidiasis in ICU patients were performed AbstractText: Searches were performed on ... reference lists AbstractText: The primary outcomes were mortality and invasive candidiasis... conclusions for prevention of infection AbstractText: Antifungal prevention of systemic candidiasis in immunocompetent critically ill adults did not reduce mortality and ...
Infectious Diseases (5) Candidiasis (5), Infections (4), more mentions
Candidiasis and certain types of cancer are related to immunocompromised status. This study aimed to evaluate whether Candida infection (CI) is associated with subsequent cancer risk in Taiwan.Data from the National Health Insurance system of Taiwan were used to evaluate the association between CI and cancer risk. The CI cohort comprised 34,829 patients.
Background: The estimated attributable mortality rate for invasive candidiasis (IC) in the Intensive Care Unit (ICU) setting varies from ... Results: Data from 19 patients with suspected or proven invasive candidiasis were available for analysis... of the 17 evaluable patients (17.6%) diagnosed with proven invasive candidiasis did not meet the AUC/MIC target of 5000.
AbstractText: Recurrent vulvovaginal candidiasis (RVVC) is acommon opportunistic, mucosal fungal infection, predominantly caused by the fungus Candida albicans.Mannose-binding lectin (MBL) is an acute-phase protein that plays a key role in the innate immunity defense against infectious disease AbstractText: The present study was conducted ... Keyword: recurrent vulvovaginal candidiasis.
Since chronic mucocutaneous candidiasis (CMC) is caused by defects in the IL-17 pathway, CMC risk data has been touted as providing ... antagonists beyond the safety results from clinical trials, and perhaps caution should be taken with the development of candidiasis in patients taking these medications Keyword: Chronic Mucocutaneous Candidiasis.
DescriptorName: Candidiasis, Invasive... Abstract: To identify the epidemiology, treatments, outcomes, and risk factors for patients with early- or late-onset invasive candidiasis (EOIC or LOIC) in intensive care units in China.Patients were classified as EOIC (≤10 days) or LOIC (>10 days) according to the time from hospital admission to ...
AbstractText: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions AbstractText: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes ... skin lesions in neutropenic patients with candidemia or acute disseminated candidiasis. 5) Has antifungal prophylaxis decreased the incidence of acute disseminated candidiasis with skin lesions.
The frequency of autoimmunity against the parathyroid glands in patients with polyglandular autoimmunity that is not due to autoimmunepolyendocrinesyndrome type 1 (APS1) is unclear. To investigate this, the current study aimed to determine the prevalence of autoantibodies against parathyroid autoantigens the calcium-sensing receptor (CaSR) and NACHT leucine-rich-repeat protein 5 (NALP5) in a large group of ...
Candida albicans is the most common fungal microorganism in healthy individuals, as well as the cause of high mortality infections in high-risk hosts such as immunocompromised patients. Antifungal vaccines and monoclonal antibodies useful for active or passive immunizations have recently generated considerable excitement for the treatment of fungal infections. The cell wall proteins of C. albicans, which are crucial for virulence and pathogenicity, are attractive target antigens. Als3p, a member of the C. albicans agglutinin-like sequence (ALS) family, is a hyphal-specific glycophosphatidylinositol cell wall protein that plays a key role in the interaction with host cells. The abundance of Als3p on the hyphal surface makes it an attractive target. For example, the NDV-3 vaccine, targeted at the N-terminus of Als3p, has entered a preparation of Phase 2 clinical trial. The Als3p-specific antibodies include monoclonal antibodies (MAbs) 3-A5, MAb 113, and scFv3. In addition, MAb C7, MAb 3D9.3 and MAb 2G8, which were supposed to be identifying other targets, have also provided good protection by recognizing Als3p. In this review, we summarize the functions of Als3p and highlight the development of the vaccines and the antibodies that are associated, directly or indirectly, with this protein.
... an autosomal-recessive monogenic inborn error of immunity conferring susceptibility to invasive fungal diseases, including the very distinct syndrome of spontaneous central nervous system candidiasis, in which opportunistic yeast of the genus Candida infect the central nervous system (either brain parenchyma and/or meninges) in the absence of trauma ... Keyword: candidiasis.
We present the case of the 56 year old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy induced neutropenia. For the first time, we provide flow cytometry based diagnostics with Candida reactive T cells for invasive candidiasis with comprehensive MRI imaging... Keyword: Invasive candidiasis. Keyword: candidaemia.
... Candida species biofilms, C. albicans lost dominance in the presence of antifungals. Interestingly, presence in mixed versus monospecies biofilms reduced susceptibility to amphotericin B for C. tropicalis and C. glabrata. Overall, our data suggest that antifungal treatment favors the growth of specific non- albicans Candida species in mixed- Candida species biofilms Keyword: candidiasis. Keyword: cell biology. Keyword: infectious disease medicine.