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Autoimmune Polyendocrinopathies
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Your search returned 18 results
from the time period: last 90 days.
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The Journal of clinical endocrinology and metabolism
Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene and characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency. Comprehensive characterizations of large patient cohorts are rare.To perform an extensive clinical, immunological, and genetic characterization of a large nationwide Russian APS-1 cohort.Clinical components ...
Immune System Diseases (4), Infectious Diseases (1)
Retinitis Pigmentosa (1), Addison Disease (1), Autoimmune Diseases (1), more mentions
In this study we investigated the circadian pattern of Clock-related genes in patients with polyglandular autoimmune syndrome type III (PAS type III) AbstractText: Nineteen patients diagnosed with PAS type III and 12 healthy controls were enrolled. mRNA and protein expression of Clock-related genes (CLOCK, BMAL1, ROR and Per-1,-2,-3), as well as the GR-a and ...
Immune System Diseases (2), more mentions
Critical care medicine
... controlled trials comparing any antifungal use versus placebo to prevent candidiasis in ICU patients were performed AbstractText: Searches were performed on ... reference lists AbstractText: The primary outcomes were mortality and invasive candidiasis... conclusions for prevention of infection AbstractText: Antifungal prevention of systemic candidiasis in immunocompetent critically ill adults did not reduce mortality and ...
Infectious Diseases (4)
Candidiasis (4), Infections (4), more mentions
Journal of cutaneous pathology
Chronic hyperplastic candidiasis (CHC) is described within the oral mucosa and the most commonly affected sites are the buccal commissures, cheeks, palate and tongue. In the oral, pharyngeal, and laryngeal mucosae, verrucous epidermal hyperplasia (VEH), pseudocarcinomatous hyperplasia (PCH), epithelial dysplasia, and a verrucous clinical appearance have all been reported in association with CHC.
Infectious Diseases (2)
Candidiasis (2), Hyperplasia (2), more mentions
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
AbstractText: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions AbstractText: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes ... skin lesions in neutropenic patients with candidemia or acute disseminated candidiasis. 5) Has antifungal prophylaxis decreased the incidence of acute disseminated candidiasis with skin lesions.
Infectious Diseases (8), Oncology (1)
Candidiasis (8), Candidemia (2), Neutropenia (1), more mentions
PloS one
A clinical diagnosis of candidiasis was determined on the basis of a positive potassium hydroxide (KOH) test and the presence of pseudomembranous (white) form of candidal overgrowth. The Cox proportional hazard regression model was used to test the association of OPC and related survival rates AbstractText: Compared with the non-OPC group, the OPC group had significantly increased occurrence rates ...
Infectious Diseases (2), Anti-Obesity and Weight Loss (2), Oncology (1)
Carcinoma (2), Candidiasis (2), Mucositis (1), more mentions
AbstractText: Candidiasis and certain types of cancer are related to immunocompromised status... Keyword: candidiasis. Keyword: population-based cohort study.
Oncology (8), Infectious Diseases (3)
Neoplasms (8), Candidiasis (3), Hematologic Neoplasms (1), more mentions
PloS one
Initially, 60 women (30 diagnosed as suffering "mammary candidiasis" and 30 with no painful breastfeeding) were recruited to elucidate ... samples provided by 529 women with symptoms compatible with "mammary candidiasis... Medicine for the nomenclature of infectious diseases, the term "mammary candidiasis" or "nipple thrush" should be avoided when referring to such ...
Infectious Diseases (5)
Candidiasis (4), Oral Candidiasis (1), Communicable Diseases (1), more mentions
Abstract: Anidulafungin has been shown to be non-inferior to, and possibly more efficacious, than fluconazole in treating patients with invasive candidiasis (IC. This study aimed to determine the cost-effectiveness of anidulafungin vs fluconazole for treatment of IC in the Turkish setting. A decision analytic model was constructed to depict downstream economic consequences of using anidulafungin or fluconazole for ...
Infectious Diseases (2)
Candidiasis (2), more mentions
BMC infectious diseases
... Cost-effectiveness studies of echinocandins for the treatment of invasive candidiasis, including candidemia, are rare in Asia... the cost-effectiveness of echinocandins and non-echinocandins for invasive candidiasis... and probability sensitivity analyses were conducted AbstractText: For treating invasive candidiasis (all species), as compared to fluconazole, micafungin and caspofungin are ... Echinocandins, especially anidulafungin, appear to be cost-effective for invasive candidiasis caused by C. albicans and non-albicans Candida species in ...
Infectious Diseases (5)
Candidiasis (5), Candidemia (2), Adverse Drug Reaction (1), more mentions
Antimicrobial agents and chemotherapy
Abstract: Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime... Keyword: vulvovaginal candidiasis.
Infectious Diseases (3)
Candidiasis (3), more mentions
We present the case of the 56 year old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy induced neutropenia. For the first time, we provide flow cytometry based diagnostics with Candida reactive T cells for invasive candidiasis with comprehensive MRI imaging... Keyword: Invasive candidiasis. Keyword: candidaemia.
Infectious Diseases (2)
Infections (6), Candidiasis (2), Burkitt Lymphoma (1), more mentions
Journal of dental research
... Candida species biofilms, C. albicans lost dominance in the presence of antifungals. Interestingly, presence in mixed versus monospecies biofilms reduced susceptibility to amphotericin B for C. tropicalis and C. glabrata. Overall, our data suggest that antifungal treatment favors the growth of specific non- albicans Candida species in mixed- Candida species biofilms Keyword: candidiasis. Keyword: cell biology. Keyword: infectious disease medicine.
Infectious Diseases (1)
Infections (3), Oral Candidiasis (1), Communicable Diseases (1), more mentions
14. Candidemia in the Intensive Care Unit.  
Date: 08/11/2017
Clinics in chest medicine
The absence of well-established molecular techniques for early detection of candidemia hinders efforts to reduce the heavy clinical and economic impact of this infection. Echinocandins are the recommended antifungal drug class for the treatment of ICU candidemia Keyword: Candida. Keyword: Candidemia. Keyword: Critical care. Keyword: Fungal infection. Keyword: Intensive care unit. Keyword: Invasive candidiasis.
Infectious Diseases (1)
Candidemia (6), Infections (3), Candidiasis (1), more mentions
... 2007 to 48.76 DDD/1000 HD in 2016), and the total treatment cost tripled during the study period. No significant change in fungal ecology or in the emergence of resistant species was observed; indeed, only 1.1% of isolates presented an unusual resistance to antifungal agents Keyword: antifungal consumption. Keyword: antifungal susceptibility testing. Keyword: candidaemia. Keyword: fungal epidemiology. Keyword: invasive candidiasis.
Infectious Diseases (1)
Infections (4), Candidiasis (1), more mentions
Infectious disease clinics of North America
... exposed to multiple stressors that predispose them to invasive fungal infections (IFIs), which carry high morbidity and mortality. Getting acquainted with the diagnostic methods and therapies is imperative for patient safety and for providing high-quality health care. This article focuses on the most frequent IFIs: invasive candidiasis and invasive aspergillosis Keyword: Antifungal... Keyword: Candidiasis. Keyword: Fungal infection. Keyword: ICU.
Infectious Diseases (2)
Infections (3), Aspergillosis (2), Candidiasis (2), more mentions
International journal of antimicrobial agents
... of different dosages of caspofungin in the treatment of invasive candidiasis and aspergillosis, in relation to the probability of pharmacokinetic/pharmacodynamic ... 24 hours and the minimal inhibitory concentration (AUC/MIC) for candidiasis or the minimal effective concentrations (AUC/MEC) for Aspergillus spp... Target attainment was >90% both for candidiasis (MIC≤0.06 mg/L) and aspergillosis (MEC≤0.5 mg/L ...
Infectious Diseases (4)
Candidiasis (4), Aspergillosis (2), Infections (1), more mentions
Candida albicans is the most common fungal microorganism in healthy individuals, as well as the cause of high mortality infections in high-risk hosts such as immunocompromised patients. Antifungal vaccines and monoclonal antibodies useful for active or passive immunizations have recently generated considerable excitement for the treatment of fungal infections. The cell wall proteins of C. albicans, which are crucial for virulence and pathogenicity, are attractive target antigens. Als3p, a member of the C. albicans agglutinin-like sequence (ALS) family, is a hyphal-specific glycophosphatidylinositol cell wall protein that plays a key role in the interaction with host cells. The abundance of Als3p on the hyphal surface makes it an attractive target. For example, the NDV-3 vaccine, targeted at the N-terminus of Als3p, has entered a preparation of Phase 2 clinical trial. The Als3p-specific antibodies include monoclonal antibodies (MAbs) 3-A5, MAb 113, and scFv3. In addition, MAb C7, MAb 3D9.3 and MAb 2G8, which were supposed to be identifying other targets, have also provided good protection by recognizing Als3p. In this review, we summarize the functions of Als3p and highlight the development of the vaccines and the antibodies that are associated, directly or indirectly, with this protein.
Vaccines (4)
Infections (3), more mentions