AbstractText: Patients with adrenalinsufficiency (AI) require lifelong glucocorticoid (GC) replacement therapy... Further studies are needed to ascertain if salivary cortisol could be used as a biomarker to manage GC replacement therapy Keyword: adrenalinsufficiency. Keyword: area under the curve. Keyword: cortisol rhythm. Keyword: glucocorticoid therapy. Keyword: salivary cortisol.
... receiving long-term glucocorticoid treatment are at risk of developing adrenalinsufficiency during treatment. We investigated the prevalence of prednisolone-induced adrenalinsufficiency in the particular clinical situation where patients receive ongoing low ... generally low and anti-adrenal antibodies were negative indicating secondary adrenalinsufficiency as the most likely diagnosis.
Immune System Diseases (3) Adrenal Insufficiency (5), Rheumatoid Arthritis (3), more mentions
AbstractText: Mineralocorticoid (MC) replacement therapy in patients with primary adrenalinsufficiency (PAI) was introduced more than 60 years ago... conducted a systematic review of the literature from 1939 to 2017, with the following keywords: 'adrenalinsufficiency', 'mineralocorticoid deficiency', 'aldosterone', 'cardiovascular disease', 'hypertension', and 'heart failure' AbstractText: The current standard treatment consists ...
Albeit a rare disease entity, EPs need to keep this life threatening disease process in the back of their minds when presented with a patient with vague symptoms such as weakness or fatigue, electrolyte abnormalities and darkening of their skin Keyword: Addison's disease. Keyword: Altered mental status. Keyword: Hyponatremia. Keyword: Hypovolemia. Keyword: Primary adrenalinsufficiency.
Men's Health (4) Addison Disease (2), Hyponatremia (1), Tachycardia (1), more mentions
... cortisol levels but there is a lag in their rise up to 60mins. The results support further research for possible future use of a 60min salivary cortisone measurement during the synacthen test. This article is protected by copyright. All rights reserved Keyword: ACTH stimulation test. Keyword: Addisons. Keyword: Cortisol. Keyword: Cosyntropin. Keyword: Saliva. Keyword: Synacthen. Keyword: adrenalinsufficiency. Keyword: cortisone.
PURPOSE: The pathophysiology behind autoimmune Addison's disease (AAD) is poorly understood, and the relative influence of genetic and environmental factors remains unclear. In this study, we examined the heritability of AAD and explored disease-associated autoimmune comorbidity among Swedish twins.
METHODS: A population-based longitudinal cohort of 112,100 Swedish twins was used to calculate the heritability of AAD, and to explore co-occurrence of 10 organ-specific autoimmune disorders in twin pairs with AAD. Diagnoses were collected 1964-2012 through linkage to the Swedish National Patient Register. The Swedish Prescribed Drug Register was used for additional diagnostic precision. When available, biobank serum samples were used to ascertain the AAD diagnosis through identification of 21-hydroxylase autoantibodies.
RESULTS: We identified 29 twins with AAD. Five out of nine (5/9) monozygotic pairs and zero out of fifteen (0/15) dizygotic pairs were concordant for AAD. The probandwise concordance for monozygotic twins was 0.71 (95% CI 0.40-0.90) and the heritability 0.97 (95% CI 0.88-99). Autoimmune disease patterns of monozygotic twin pairs affected by AAD displayed a higher degree of similarity than those of dizygotic twins, with an incidence rate ratio of 15 (95% CI 1.8-116) on the number of shared autoimmune diagnoses within pairs.
CONCLUSIONS: The heritability of AAD appears to be very high, emphasizing the need for further research on the genetic etiology of the disease. Monozygotic twin concordance for multiple autoimmune manifestations suggests strong genetic influence on disease specificity in organ-specific autoimmunity.
Immune System Diseases (6) Addison Disease (2), Autoimmune Diseases (1), more mentions
Abstract: Acute adrenalcrisis is a life-threatening medical emergency requiring immediate recognition and ... Among individuals with primary adrenalinsufficiency it has a frequency of 6-8 per 100 patient ... Unfortunately, delays in diagnosis and management of acute adrenalcrisis are commonplace - even in patients with documented steroid-dependency - constituting ... Keyword: adrenalcrisis.