... catheterization data, 147 patients (63.4%) were classified as having a disease involving the mitralvalve; 93 (40.1%), aorticvalve; 37 (15.9%), tricuspid valve; and 4 (1.7%), pulmonary valve ... multivariate linear regression analysis, adjusting the type and mechanism of valvedisease and clinical, echocardiographic, and/or other catheterization parameters, WMH volume ...
Cardiovascular Diseases (5) Heart Valve Diseases (4), Heart Diseases (2), Central Nervous System Diseases (1), more mentions
Abstract: Calcific aorticvalvestenosis (CAVS) is common in the ageing population and set to become an increasing economic and health ... Therefore, aortic valvereplacement remains the only available treatment option... emphasis on recent insights into calcification, methods for imaging calcification activity, and potential therapeutic options Keyword: Aorticvalvestenosis.
AbstractText: Unlike degenerative mitralvalve (MV) disease, the advantages of valverepair procedure over replacement have been debated in rheumatic MV disease ... matched cohort (HR, 1.62; 95% CI 0.49 to 5.28) AbstractText: Valverepair in well-selected patients with severe rheumatic MV disease led ... to comparable survival, but superior valve-related outcomes compared with valvereplacementsurgery Keyword: mitral regurgitation.
Abstract: Aortic stenosis (AS) is the most common form of valvularheartdisease... Surgical aortic valvereplacement (SAVR) is curative but has significant limitations for some patient ... A newer option, transcatheter aortic valvereplacement (TAVR), has become more widely available to patients with intermediate- or ... Keyword: transcatheter aortic valvereplacement.
AbstractText: Although guidelines support aortic valvereplacement (AVR) in patients with severe aortic regurgitation (AR) and left ventricular ejection fraction (LVEF) <50%, severe left ventricular dysfunction (LVEF <35%) is thought to confer high surgical risk... Keyword: valvediseasesurgery.
AbstractText: Iliofemoral arterial disease can preclude transfemoral (TF) transcatheter aorticvalvereplacement (TF-TAVR... with SCA accesses AbstractText: Major morbidity and mortality rates SCA-TAVR are equivalent to TF-TAVR. The SCA should be the preferred secondary access site for TAVR because it offers procedural and clinical outcomes comparable to TF-TAVR and applies to most patients who are not TF candidates ...
We describe a biosimulator that recapitulates normal heart valve physiology with associated real-time hemodynamic performance.To highlight the advantages of this simulation platform, transventricular extruded polytetrafluoroethylene artificial chordae were attached to repair flail or prolapsingmitralvalve leaflets. Guidance for key repair steps was by 2-dimensional/3-dimensional echocardiography and simultaneous intracardiac videoscopy.Multiple surgeons have assessed the ...
... AbstractText: The authors examined the commercial experience with transcatheter mitral valverepair for the treatment of mitral regurgitation AbstractText: Data from the Society of Thoracic Surgery/American College of Cardiology TranscatheterValveTherapy Registry on patients commercially treated with transcatheter mitral valverepair were analyzed ... tricuspid regurgitation AbstractText: Our findings demonstrate that commercial transcatheter mitral valverepair is being performed in the United States with acute effectiveness ...
Intravascular hemolysis (IVH) has been identified in patients with surgical prosthetic valves, but few have been reported after transcatheter aortic valve implantation (TAVI). We conducted a prospective analysis of 64 TAVI patients. The hemolysis profiles were collected at baseline and 6 months after TAVI. The echocardiography was performed at baseline and 6 months after TAVI. There are 14 patients (21.9%) with IVH before and 24(37.5%) after TAVI. The serum haptoglobin values before and 6 months after TAVI are 126.7 ± 75.1 vs 86.3 ± 57.1 mg/dl (p < 0.001). More ≥moderate paravalvular leakage (PVL) (50% vs 7.5%, p < 0.001), bicuspid aortic valve (BAV) (33.3% vs 5.0%, p = 0.004), use of 23 mm prosthesis (29.2% vs 7.5%, p = 0.03), higher residual valvular pressure gradient (17.9 ± 6.8 mm Hg vs 14.7 ± 5.7 mm Hg, p = 0.05), and lower effective orifice area index (1.05 ± 0.21 vs 1.21 ± 0.29, p = 0.03) were observed in patients with post-TAVI IVH. On multivariate regression analysis, BAV and ≥moderate PVL are independently related to post-TAVI IVH. With log-rank test, 1-year rates of readmission due to cardiovascular cause were significantly higher in patients with post-TAVI IVH (odds ratio 4.5; 95% confidence interval 1.3 to 15.6; p = 0.02), after adjusting age and gender. In conclusion, ≥moderate PVL and BAV are predictors of post-TAVI IVH, which is associated with increased cardiovascular readmission in 1-year follow-up.
OBJECTIVE: It is intuitive to suggest that knowledge of the variation in the anatomy of the aortic root may influence the outcomes of transcatheter implantation of the aortic valve (TAVI). We have now assessed such variation.
METHODS: We used 26 specimens of normal hearts and 78 CT data sets of adults with a mean age of 64±15 years to measure the dimensions of the membranous septum and to assess any influence played by rotation of the aortic root, inferring the relationship to the atrioventricular conduction axis.
RESULTS: The aortic root was positioned centrally in the majority of both cohorts, although with significant variability. For the cadaveric hearts, 14 roots were central (54%), 4 clockwise-rotated (15%) and 8 counterclockwise-rotated (31%). In the adult CT cohort, 44 were central (56%), 21 clockwise-rotated (27%) and 13 counterclockwise-rotated (17%). A mean angle of 15.5° was measured relative to the right fibrous trigone in the adult CT cohort, with a range of -32° to 44.7°. The dimensions of the membranous septum were independent of rotation. Fibrous continuity between the membranous septum and the right fibrous trigone increased with counterclockwise to clockwise rotation, implying variation in the relationship to the atrioventricular conduction axis.
CONCLUSIONS: The central fibrous body is wider, providing greater fibrous support, in the setting of clockwise rotation of the aortic root. Individuals with this pattern may be more vulnerable to conduction damage following TAVI. Knowledge of such variation may prove invaluable for risk stratification.
AbstractText: Mitralvalveprolapse has been associated with increased risk of ventricular arrhythmias ... screened electronic medical records of all patients documented to have mitralvalveprolapse on either transthoracic echocardiogram (TTE) or cardiac magnetic resonance imaging ... with papillary muscle origin of ventricular arrhythmias in patients with mitralvalveprolapse Keyword: cardiac magnetic resonance imaging.
... Two single-nucleotide polymorphisms in the LPA locus, rs10455872 and rs3798220, that are known to associate with circulating plasma lipoprotein(a) levels and an LPA risk score AbstractText: Aortic stenosis or aorticvalvereplacement AbstractText: The 44 703 participants were of European ancestry,of whom 22 019 (49.3%) were men.
We analyzed 601 patients presenting with severe native aorticvalvestenosis treated with either Sapien XT (n = 405, 2011 to 2014, mean STS-PROM [Society of Thoracic Surgeons predicted risk of mortality] 11.0%) or Sapien 3 prosthesis (n = 196, 2014 to 2016, mean STS-PROM 9.2. Beside a propensity score-based comparison, we modeled the likelihood of PVL as a ...
DescriptorName: Ventricular Remodeling. AbstractText: Pulmonary valvereplacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate of ventricular structural and functional adaptation are scarce. We aimed to assess immediate and midterm post-PVR changes and predictors of reverse remoeling AbstractText: Fifty-seven patients with repaired tetralogy of ...
Tetralogy of Fallot (5), Ventricular Remodeling (2), more mentions
... study sought to examine long-term outcomes with transcatheter aortic valvereplacement (TAVR) in women versus men AbstractText: TAVR is commonly performed in women ... conflicting results with respect to sex differences in outcomes with TAVR... of complications, women derive a better long-term survival after TAVR compared with men Keyword: TAVR. Keyword: aortic valvereplacement.
Cardiovascular Diseases (2) Transient Ischemic Attack (1), more mentions