Abstract: Background - Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are a novel class of medications for patients with familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease (ASCVD) requiring additional lipid lowering beyond dietary measures and statin use. Because of the drugs' high cost, rates of prescription approval by payers may be low.
Cardiovascular Diseases (4) Hyperlipoproteinemia Type II (1), Cardiovascular Diseases (1), more mentions
AbstractText: Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the ... patients AbstractText: We analyzed data from 3167 adults enrolled in the CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia (CASCADE-FH) registry... Keyword: Familial hypercholesterolemia. Keyword: Hyperlipidemia.
Cardiovascular Diseases (5) Hyperlipoproteinemia Type II (4), Hyperlipidemias (1), more mentions
... and the anastomotic technique, also play a major role in determining graft success. Furthermore, systemic atherosclerotic risk factors, such as age, sex, diabetes mellitus, hypertension, and dyslipidemia, have been variably associated with graft failure. The failure of a coronary graft is not always correlated with adverse clinical events, which vary according to the type, location, and reason for failed graft.
Cardiovascular Diseases (1), Endocrine Disorders (1), Blood Disorders and Hematology (1) Dyslipidemias (1), Thrombosis (1), Pathologic Constriction (1), more mentions
Response by Pérez de Isla et al to Letter Regarding Article, "Predicting Cardiovascular Events in Familial Hypercholesterolemia: The SAFEHEART Registry (Spanish Familial Hypercholesterolemia Cohort Study)"..
Mediterranean Diet (Med-Diet) is effective for cardiovascular prevention, but its relationship with NAFLD has been scarcely investigated AbstractText: We included 584 consecutive outpatients presenting with one or more cardiovascular risk factor such as type 2 diabetes mellitus (T2DM), arterial hypertension, overweight/obesity, and dyslipidemia. Liver steatosis was assessed using ultrasonography.
Endocrine Disorders (5), Anti-Obesity and Weight Loss (2), Cardiovascular Diseases (1) Insulin Resistance (4), Hypertriglyceridemia (2), Alcoholic Fatty Liver (2), more mentions
Methods -We performed an eighteen-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to iso-caloric low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet+28g walnuts/day with/without added moderate physical activity (PA;80% aerobic; supervised/free gym membership.
Anti-Obesity and Weight Loss (7), Blood Disorders and Hematology (1) Dyslipidemias (1), Abdominal Obesity (1), Obesity (1), more mentions
Anxiety (40.2%), depression (21.1%), hypertension (17.7%), migraine (18.1%), and hyperlipidemia (11.9%) were the most prevalent comorbidities... Migraine and hyperlipidemia were associated with increased relapse rate (adjusted rate ratio 1.38 ... 1.67; 95% CI 1.07-2.61, respectively) AbstractText: Individuals with migraine, hyperlipidemia, or a high comorbidity burden (3 or more conditions) had ...
Pain Management (3), Immune System Diseases (2), Neuroscience (1) Multiple Sclerosis (7), Migraine Disorders (3), Hyperlipidemias (3), more mentions
AbstractText: A 47-year-old man with a medical history of hypertension, diabetes, hyperlipidemia, and OSA presented with a 7- to 10-day history of progressively worsening dyspnea on exertion, with a walking distance of 60 feet. He had bilateral lower-extremity swelling and was prescribed furosemide without clinical improvement.
Cardiovascular Diseases (1), Endocrine Disorders (1), Anti-Obesity and Weight Loss (1) Pleural Effusion (1), Hypertension (1), Hemoptysis (1), more mentions
Lower DASI scores correlated with age and use of medications for hypertension, cardiac conditions, diabetes, and hyperlipidemia, but not with whether patients had received trastuzumab. Conclusion In patients without underlying cardiac disease at baseline, the addition of trastuzumab to adjuvant anthracycline and taxane-based chemotherapy does not result in long-term worsening of cardiac function, cardiac symptoms, or health-related ...
Oncology (4), Cardiovascular Diseases (1), Endocrine Disorders (1) Neoplasms (2), Breast Neoplasms (2), Heart Diseases (1), more mentions
... 130 mg/dl within the respective age groups was 8.0, 15.4, and 23.7% among patients and 1.8, 12.5, and 11.8% among controls AbstractText: Noncommunicable diseases were a significant burden in Malawi, with high prevalence of hypercholesterolemia in all survey participants and an especially acute diabetes burden among older HIV infected.
Abstract: Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to changes in lifestyle and dietary structure in recent years. MS has been proven to be associated with an increased incidence of cardiovascular diseases and type 2 diabetes mellitus, leading to morbidity and mortality.
Cardiovascular Diseases (3), Endocrine Disorders (2), Anti-Obesity and Weight Loss (2) Diabetes Mellitus, Type 2 (2), Cardiovascular Diseases (2), Abdominal Obesity (1), more mentions
Patients with diabetes mellitus and hypercholesterolemia had significantly higher adjusted relative hazard (3.37 and 1.41; P < 0.001 and P = 0.014), respectively AbstractText: CKD incidence among the Thai HIV-infected patients was lower than ... Diabetes, hypercholesterolemia, age, and HIV viral load were the significant risk factors AbstractText: ClinicalTrials.gov identifier: NCT01328275.
AbstractText: Evaluation of cardiovascular prognosis in patients with stable coronary heart disease is based on clinical characteristics and biomarkers indicating dysglycemia, dyslipidemia, renal dysfunction, and possibly cardiac dysfunction. Inflammation plays a key role in atherosclerosis, but the association between inflammatory biomarkers and clinical outcomes is less studied in this population AbstractText: Overall, 15Â 828 patients with coronary heart disease in ...
Multimorbidity was irreversible, defined as having ≥2 of: hypertension, diabetes mellitus, chronic kidney disease, hypercholesterolemia, end-stage liver disease, or non-AIDS-related cancer... Hypertension and hypercholesterolemia most commonly co-occurred AbstractText: Multimorbidity prevalence has increased among persons living with HIV. Comorbidity prevention and multi-subspecialty management of increasingly complex healthcare needs will be vital to ensuring they receive needed ...
Immune System Diseases (9), Cardiovascular Diseases (2), Kidney Disease (1) Hypertension (2), Hypercholesterolemia (2), Liver Diseases (1), more mentions
Seventeen patients ranging in age from 37 to 49 years (mean, 43.7 years) met the study criteria, and they were all female. Fifteen patients had both history of hyperlipidemia and smoking with a mean of 53.2 pack-years... Most of these patients are heavy smokers with hyperlipidemia. PTA alone or with stenting has favorable midterm results.
Midlife hypertension and hyperlipidemia were associated with 29% (prevalence ratio [PR], 1.29; 95% CI, 1.08-1.55) and 18% (PR, 1.18; 95% CI ... Midlife smoking and diabetes were strongly associated with late-life ICAD in blacks only, whereas midlife hypertension and hyperlipidemia were associated with late-life ICAD in both races.
... the median age was 62 years (IQR, 56 - 70), 69% were males, 64% had hypertension, 40% dyslipidemia, 39% diabetes mellitus, 30% used tobacco, and 24% were obese... After adjusting for age, sex, hypertension, dyslipidemia, diabetes mellitus, tobacco use, obesity and family history of coronary artery disease, LTBI remained independently associated ...