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Coronary Heart Disease
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Coronary Artery Disease (CAD) refers to the luminal narrowing of a coronary artery, usually due to atherosclerosis. CAD is he leading contributor to ischemic heart disease (IHD). IHD includes angina pectoris, myocardial infarction (MI), and silent myocardial ischemia. From the Washington Manual of Medical Therapeutics, 35e

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Lancet (London, England) 
BACKGROUND: Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration of DAPT in such patients. METHODS: In this randomised single-blind trial, we recruited patients from 44 centres in nine countries. Patients were eligible if they were aged 75 years or older; had stable angina, silent ischaemia, or an acute coronary syndrome; and had at least one coronary artery with a stenosis of at least 70% (≥50% for the left main stem) deemed eligible for percutaneous coronary intervention (PCI). Exclusion criteria were indication for myocardial revascularisation by coronary artery bypass grafting; inability to tolerate, obtain, or comply with DAPT; requirement for additional surgery; non-cardiac comorbidities with a life expectancy of less than 1 year; previous haemorrhagic stroke; allergy to aspirin or P2Y12 inhibitors; contraindication to P2Y12 inhibitors; and silent ischaemia of less than 10% of the left myocardium with a fractional flow reserve of 0·80 or higher. After the intended duration of DAPT was recorded (1 month for patients with stable presentation and 6 months for those with unstable presentation), patients were randomly allocated (1:1) by a central computer system (blocking used with randomly selected block sizes [two, four, eight, or 16]; stratified by site and antiplatelet agent) to either a DES or similar BMS in a single-blind fashion (ie, patients were masked), but those assessing outcomes were masked. The primary outcome was to compare major adverse cardiac and cerebrovascular events (ie, a composite of all-cause mortality, myocardial infarction, stroke, or ischaemia-driven target lesion revascularisation) between groups at 1 year in the intention-to-treat population, assessed at 30 days, 180 days, and 1 year. This trial is registered with ClinicalTrials.gov, number NCT02099617. FINDINGS: Between May 21, 2014, and April 16, 2016, we randomly assigned 1200 patients (596 [50%] to the DES group and 604 [50%] to the BMS group). The primary endpoint occurred in 68 (12%) patients in the DES group and 98 (16%) in the BMS group (relative risk [RR] 0·71 [95% CI 0·52-0·94]; p=0·02). Bleeding complications (26 [5%] in the DES group vs 29 [5%] in the BMS group; RR 0·90 [0·51-1·54]; p=0·68) and stent thrombosis (three [1%] vs eight [1%]; RR 0·38 [0·00-1·48]; p=0·13) at 1 year were infrequent in both groups. INTERPRETATION: Among elderly patients who have PCI, a DES and a short duration of DAPT are better than BMS and a similar duration of DAPT with respect to the occurrence of all-cause mortality, myocardial infarction, stroke, and ischaemia-driven target lesion revascularisation. A strategy of combination of a DES to reduce the risk of subsequent repeat revascularisations with a short BMS-like DAPT regimen to reduce the risk of bleeding event is an attractive option for elderly patients who have PCI. FUNDING: Boston Scientific.
Senior Health (4), Cardiovascular Diseases (4)
Myocardial Infarction (2), Thrombosis (1), Allergy (1), more mentions
Circulation 
... outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone... fractional flow reserve with best MT in patients with stable coronary artery disease to assess clinical outcomes and cost-effectiveness... total of 888 patients with stable single-vessel or multivessel coronary artery disease with reduced fractional flow reserve were randomly assigned to PCI ...
Coronary Artery Disease (6), Myocardial Infarction (2), more mentions
Lancet (London, England) 
... in combination or against each other in patients with stable coronary artery disease AbstractText: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics ... Eligible patients with coronary artery disease had to have had a myocardial infarction in the past 20 years, multi-vessel coronary artery disease, history of stable or unstable angina, previous multi-vessel percutaneous ...
Cardiovascular Diseases (1)
Coronary Artery Disease (10), Myocardial Infarction (2), Unstable Angina (1), more mentions
The American journal of cardiology
... physical activity (LTPA) is associated with longevity in patients with coronary artery disease (CAD... prognostic significance of longitudinally assessed LTPA in patients with stable CAD... between changes in LTPA and cardiac mortality in patients with CAD. Patients with angiographically documented CAD (n = 1,746) underwent clinical examination and echocardiography at the ...
Cardiovascular Diseases (1), Endocrine Disorders (1), Anti-Obesity and Weight Loss (1)
Coronary Artery Disease (2), Myocardial Infarction (1), Angina Pectoris (1), more mentions
The American journal of cardiology
Abstract: Exercise capacity is a strong predictor of survival rate in patients with and without coronary artery disease. Exercise-based cardiac rehabilitation (CR) with improvements in the peak oxygen uptake (VO2peak) of 3.5 ml/kg/min or more has been shown to be beneficial in earlier observational studies. Long-term results on VO2peak after CR are rare.
Anti-Obesity and Weight Loss (1)
Coronary Artery Disease (2), more mentions
Mayo Clinic proceedings 
OBJECTIVE: To evaluate 25-year physical activity (PA) trajectories from young to middle age and assess associations with the prevalence of coronary artery calcification (CAC). PATIENTS AND METHODS: This study includes 3175 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who self-reported PA by questionnaire at 8 follow-up examinations over 25 years (from March 1985-June 1986 through June 2010-May 2011). The presence of CAC (CAC>0) at year 25 was measured using computed tomography. Group-based trajectory modeling was used to identify PA trajectories with increasing age. RESULTS: We identified 3 distinct PA trajectories: trajectory 1, below PA guidelines (n=1813; 57.1%); trajectory 2, meeting PA guidelines (n=1094; 34.5%); and trajectory 3, 3 times PA guidelines (n=268; 8.4%). Trajectory 3 participants had higher adjusted odds of CAC>0 (adjusted odds ratio [OR], 1.27; 95% CI, 0.95-1.70) vs those in trajectory 1. Stratification by race showed that white participants who engaged in PA 3 times the guidelines had higher odds of developing CAC>0 (OR, 1.80; 95% CI, 1.21-2.67). Further stratification by sex showed higher odds for white males (OR, 1.86; 95% CI, 1.16-2.98), and similar but nonsignificant trends were noted for white females (OR, 1.71; 95% CI, 0.79-3.71). However, no such higher odds of CAC>0 for trajectory 3 were observed for black participants. CONCLUSION: White individuals who participated in 3 times the recommended PA guidelines over 25 years had higher odds of developing coronary subclinical atherosclerosis by middle age. These findings warrant further exploration, especially by race, into possible biological mechanisms for CAC risk at very high levels of PA.
Cardiovascular Diseases (1)
Coronary Artery Disease (1), Atherosclerosis (1), more mentions
Diabetologia
... incident non-diabetes CHD (HR 1.29, 95% CI 0.86, 1.93) AbstractText: The associations between sleep duration and incident CHD directly reflect the associations between sleep duration and incident diabetes. Incident diabetes may thus be the explanatory mechanism for the association between short and long sleep duration and incident CHD Keyword: Cohort. Keyword: Coronary heart disease. Keyword: Diabetes mellitus. Keyword: Epidemiology.
Endocrine Disorders (26), Cardiovascular Diseases (2), Oncology (1)
Diabetes Mellitus (26), Coronary Disease (2), Neoplasms (1), more mentions
Heart (British Cardiac Society)
AbstractText: To assess the associations between ambient temperatures and hospitalisations for coronary heart disease (CHD) and stroke AbstractText: Our study comprised all residents living in Ontario, Canada, 1996-2013. For each of 14 health regions, we fitted a distributed lag non-linear model to estimate the cold and heat effects on hospitalisations from CHD, acute myocardial infarction (AMI), stroke and ...
Cardiovascular Diseases (3)
Coronary Disease (2), Heart Diseases (1), Myocardial Infarction (1), more mentions
Journal of clinical nursing
... physical activity, vegetable and alcohol consumption, LDL-cholesterol, duration of coronary heart disease without previous percutaneous coronary intervention were predictors of adherence AbstractText ... relationship, longer education, lower LDL-cholesterol and longer duration of coronary heart disease without previous percutaneous coronary intervention AbstractText: Because a healthy lifestyle ... a close personal relationship, with low education, and a shorter coronary heart disease duration with previous coronary intervention.
Cardiovascular Diseases (7)
Coronary Disease (7), more mentions
Family practice
AbstractText: Patients with coronary heart disease (CHD) experience reduced quality of life which may be associated with mortality in the longer term. This study explores whether patient-rated physical and mental health status was associated with mortality at 6-year follow-up among patients with CHD attending primary care in Ireland and Northern Ireland AbstractText: This study is a secondary ...
Cardiovascular Diseases (2)
Coronary Disease (3), more mentions
Journal of the American Heart Association 
AbstractText: Evaluation of cardiovascular prognosis in patients with stable coronary heart disease is based on clinical characteristics and biomarkers indicating dysglycemia, dyslipidemia ... studied in this population AbstractText: Overall, 15Â 828 patients with coronary heart disease in the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of ... infarction, heart failure, and cancer mortality in patients with stable coronary heart disease.
Cardiovascular Diseases (5), Oncology (2), Blood Disorders and Hematology (1)
Coronary Disease (5), Heart Failure (2), Myocardial Infarction (2), more mentions
PloS one
AbstractText: To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population AbstractText: A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study ...
Cardiovascular Diseases (2)
Coronary Disease (3), more mentions
Journal of the American Heart Association
Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease..
Cardiovascular Diseases (2)
Coronary Disease (2), more mentions
Circulation. Cardiovascular imaging
... potential noninvasive imaging tool to identify plaques with high-risk characteristics in patients with coronary artery disease... coherence tomography (OCT), intravascular ultrasound (IVUS), and coronary computed tomography angiography in patients with coronary artery disease AbstractText: The target population consisted of 51 prospectively enrolled patients (93 stenoses) who underwent ... Keyword: coronary artery disease.
Cardiovascular Diseases (1)
Coronary Artery Disease (4), Acute Coronary Syndrome (1), Pathologic Constriction (1), more mentions
Journal of the American Heart Association 
Keyword: Coronary artery disease. Keyword: Ischemia. Keyword: Mortality. Keyword: Myocardial infarction. Keyword: Paradigm. Keyword: Percutaneous coronary intervention.
Coronary Artery Disease (2), Ischemia (1), Myocardial Infarction (1), more mentions
American heart journal
... coronary intervention (PCI) with drug-eluting stents (DES) for left main coronary artery disease (LMCAD) in a real-world setting AbstractText: A total of 3 ... CABG group, whereas those generally associated with the severity of atherosclerotic coronary artery disease were strong predictors in the PCI group AbstractText: Among patients with ...
Cardiovascular Diseases (2), Kidney Disease (1)
Myocardial Infarction (3), Coronary Artery Disease (3), Chronic Kidney Diseases (1), more mentions
Heart (British Cardiac Society)
AbstractText: Diagnosing coronary artery disease (CAD) continues to require substantial healthcare resources... accuracy of a new portable acoustic device for detection of CAD AbstractText: We included 1675 patients consecutively with low to intermediate likelihood of CAD who had been referred for cardiac CT angiography ... A predefined acoustic CAD-score algorithm was evaluated; subsequently, we developed and validated an updated CAD-score algorithm that included both acoustic features and clinical risk ... Keyword: coronary artery disease.
Coronary Artery Disease (3), Coronary Disease (1), more mentions
Digestive diseases and sciences 
... bacteria and their metabolic by-products in the development of coronary artery disease (CAD) is suspected... of small intestinal bacterial overgrowth (SIBO) with the development of CAD AbstractText: To evaluate the frequency and risk factors for angiography-confirmed CAD in patients with or without SIBO AbstractText: A total of ... risk factors, patients with SIBO may benefit from assessment for CAD Keyword: Coronary artery disease.
Cardiovascular Diseases (1), Endocrine Disorders (1), Kidney Disease (1)
Coronary Artery Disease (3), Metabolic Diseases (1), Chronic Kidney Diseases (1), more mentions
Journal of the American Heart Association
... outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease... a favorable vascular response to statin therapy in patients with coronary artery disease AbstractText: A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical ...
Cardiovascular Diseases (11), Kidney Disease (2)
Coronary Artery Disease (5), Acute Coronary Syndrome (2), Chronic Kidney Diseases (2), more mentions
Journal of the American Heart Association
... wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD... was associated with 16% to 19% lower odds of obstructive CAD (Southampton Atherosclerosis Study: odds ratio, 0.81; 95% confidence interval, 0.67 ... with similar effects for multivessel, left anterior descending, and proximal CAD... Keyword: coronary artery disease.
Cardiovascular Diseases (7)
Atherosclerosis (7), Coronary Artery Disease (3), Myocardial Infarction (1), more mentions
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