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AbstractText: Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediate-thickness melanomas (1.2 to 3.5 mm ... disease control and provided prognostic information but did not increase melanoma-specific survival among patients with melanoma and sentinel-node metastases.
Oncology (14) Melanoma (10), Lymphedema (2), Neoplasms (2), more mentions
... on the current body of evidence of targeted therapy in melanoma brain metastases through an evaluation of dabrafenib plus trametinib in patients with BRAF(V600)-mutant melanoma brain metastases AbstractText: This ongoing, multicentre, multicohort, open-label, phase ... 2 mg once per day) in four patient cohorts with melanoma brain metastases enrolled from 32 hospitals and institutions in Europe, North America, and Australia: (A) BRAF(V600E)-positive, asymptomatic melanoma brain metastases, with no previous local brain therapy, and an ...
... and clinical studies have reported a significantly increased risk for melanoma in people with Parkinson's disease... We found that treatment with anle138b leads to massive melanoma cell death due to a major dysregulation of autophagy, suggesting that α-synuclein is highly beneficial to advanced melanoma because it ensures that autophagy is maintained at a homeostatic ...
Oncology (7), Neurological and Central Nervous System Diseases (3) Melanoma (7), Parkinson Disease (3), more mentions
AbstractText: Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and ... a comprehensive DNA methylation analysis during all progression stages of melanoma using Infinium HumanMethylation450 BeadChips on a discovery cohort of benign nevi (n = 14) and malignant melanoma from both primary (n = 33) and metastatic (n = 28) sites ...
Oncology (11) Melanoma (8), Neoplasms (7), Nevus (1), more mentions
... of 78 peptide combinations derived from proteins present in the melanoma microenvironment, we identify a proteoglycan binding and bone morphogenic protein ... derived sequence that selectively promotes the expression of several putative melanoma initiating cell markers... associated with each of these peptides in the activation of melanoma pro-tumorigenic signaling and reveal a role for proteoglycan mediated ...