We describe the multi-platform molecular landscape of 206 adult softtissuesarcomas representing 6 major types... the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads ... Keyword: leiomyosarcoma.
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... many years, first-line treatment for locally advanced or metastatic soft-tissuesarcoma has been doxorubicin... versus doxorubicin as first-line treatment for advanced or metastatic soft-tissuesarcoma AbstractText: The GeDDiS trial was a randomised controlled phase 3 ... Eligible patients had histologically confirmed locally advanced or metastatic soft-tissuesarcoma of Trojani grade 2 or 3, disease progression before enrolment ...
Oncology (7) Sarcoma (9), Neutropenia (4), Neoplasms (4), more mentions
... were 19 men and 9 women [mean age: 78years (51-89. In 26 (92.8%) cases, the sarcomatoid component had nonspecific malignant spindle cells, 4 (14%) chondrosarcoma, 2 (7%) myxoid sarcomatous, 1 (3.5%) osteosarcoma, and 1 (3.5%) rhabdomyosarcoma. The predominant component was in 11 (39%) cases SCC, 6 (21%) urothelial carcinoma, 3 (10%) sarcomatoid, and 8 (29%) equal sarcomatoid and SCC.
Oncology (1) Carcinoma (8), Small Cell Carcinoma (3), Squamous Cell Carcinoma (1), more mentions
AbstractText: Studies performed in the 1980s and early 1990s have shown that people who develop Kaposisarcoma (KS) are at higher risk of developing other cancers. The demographics of those affected with human immunodeficiency virus (HIV)/AIDS and KS have changed, and individuals with HIV/AIDS and KS now live longer AbstractText: To test the hypothesis that the secondary cancers ...
Oncology (13), Immune System Diseases (8) Acquired Immunodeficiency Syndrome (4), Tongue Neoplasms (2), Penile Neoplasms (2), more mentions
Abstract: Metabolic changes within the cell and its niche affect cell fate and are involved in many diseases and disorders including cancer and viral infections. Kaposi'ssarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi'ssarcoma (KS. KSHV latently infected cells express only a subset of viral genes, mainly located within the latency-associated region, among them 12 microRNAs.
... long-term immunosuppressive treatment according to graft-specific treatment protocols AbstractText: Occurrence of first posttransplant SCC, melanoma, or Kaposisarcoma of the skin... The overall SIRs for SCC, melanoma, and Kaposisarcoma were 51.9 (95% CI, 48.4-55.5), 2.4 (95% CI, 1.9-3.0), and 54.9 (95% CI, 27.4-98.2), respectively ...
From a high throughput synthetic lethal screen, we identified a small molecule, FiVe1, which selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells and softtissuesarcomas of diverse histological subtypes. FiVe1 targets the intermediate filament and mesenchymal marker vimentin (VIM) in a mode which promotes VIM disorganization and phosphorylation during metaphase, ultimately leading to mitotic catastrophe ...
Oncology (3), Stem Cell Research (2) Neoplasms (2), Sarcoma (1), Breast Neoplasms (1), more mentions
Methods: Twenty-two cases of malignant mesothelioma including 17 epithelioid type, 2 sarcomatoid type and 3 biphasic type were collected.As the study control, 80 non-small cell lung cancers infringement pleural membrane(including 40 lung adenocarcinomas and 40 lung squamous cell carcinomas) and 15 carcinosarcomas were included. BAP1 expression was detected using immunohistochemical method.