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DescriptorName: ProstaticNeoplasms... differences in mortality between men who underwent surgery for localized prostatecancer and those who were treated with observation only... nearly 20 years of follow-up among men with localized prostatecancer, surgery was not associated with significantly lower all-cause or prostate-cancer mortality than observation ...
Oncology (8), Urology (2), Men's Health (2) Prostatic Neoplasms (6), Neoplasms (3), Urinary Incontinence (2), more mentions
AbstractText: Prostatecancer has a significant heritable component, and rare deleterious germline variants ... pathogenic germline variants in cancer-predisposing genes in men with prostatecancer and at least 1 additional primary cancer AbstractText: Using a ... panel, the authors sequenced germline DNA from 102 men with prostatecancer and at least 1 additional primary cancer who also met ...
... of 13.9 years of follow-up, there were 7024 incident prostatecancers and 934 prostatecancer deaths AbstractText: Height was not associated with total prostatecancer risk ... stronger for high-grade (HR = 1.43, 1.07-1.92) and fatal prostatecancer (HR = 1.55, 1.23-1.96) AbstractText: The findings from this large ... have greater adiposity have an elevated risk of high-grade prostatecancer and prostatecancer death Keyword: Adiposity.
Oncology (14), Anti-Obesity and Weight Loss (3) Prostatic Neoplasms (13), Obesity (2), Neoplasms (1), more mentions
... there remains ongoing debate regarding whether vasectomy is associated with prostatecancer AbstractText: To determine if vasectomy is associated with prostatecancer AbstractText: The MEDLINE, EMBASE, Web of Science, and Scopus databases ... reporting relative effect estimates for the association between vasectomy and prostatecancer were included AbstractText: Two investigators performed study selection independently.
... Exercise may reduce morbidity, increase survival and improve quality of life (QoL) in prostatecancer patients... of peer-led self-management for increasing exercise participation in men with localized prostatecancer AbstractText: Four hundred and sixty-three prostatecancer patients from Queensland, Australia were randomised to a monthly telephone-based group peer ...
Oncology (6) Prostatic Neoplasms (4), Neoplasms (1), more mentions
... 513) and Lys(519) in the iSH2 (inter-Src homology 2) domain was required for TGF-β-induced activation of PI3K-AKT signaling and cell motility in prostatecancer cells and activated macrophages... In situ proximity ligation assays revealed that polyubiquitylation of p85α was evident in aggressive prostatecancer tissues.
... long-term hypertension AbstractText: Similar to the selective use of HT with radiotherapy in localized prostatecancer, not all patients appear to derive a meaningful benefit from HT with SRT... determine the benefit and harm of adding hormone therapy to salvage radiotherapy (SRT) for recurrent prostatecancer... Keyword: Prostatecancer.
The Advanced ProstateCancer Consensus Conference (APCCC) 2017 addressed some of these topics AbstractText ... APC management were identified: high-risk localised and locally advanced prostatecancer; "oligometastatic" prostatecancer; castration-naïve and castration-resistant prostatecancer; the role of imaging in APC; osteoclast-targeted therapy; molecular ... testing; side effects of systemic treatment(s); global access to prostatecancer drugs.
Abstract: Prostatecancer is a highly heritable molecularly and clinically heterogeneous disease. To discover germline events involved in prostatecancer predisposition, we develop a computational approach to nominate heritable facilitators ... that a polymorphism at 7p14.3 may predispose to SPOP mutant prostatecancer subclass through a hormone-dependent DNA damage response.Prostatecancer is a heterogeneous disease, and many cases show somatic mutations ...
... group transcriptional repressor Bmi-1 often overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of prostatecancer... a novel functional PTMs of Bmi-1 but also reveals a unique oncogenic role of O-GlcNAcylation in prostatecancer.Oncogene advance online publication, 17 July 2017; doi:10.1038/onc.2017.223.
AbstractText: Men diagnosed with prostatecancer have increased risk for disease progression, cardiovascular events, and impairments ... life, circulating biomarkers, and morbidity among men with newly diagnosed prostatecancer AbstractText: Men were recruited at Örebro University Hospital, Sweden, and ... A walking group intervention among men with recent diagnosis of prostatecancer is feasible and potentially effective in improving cardiovascular health.
Oncology (4), Anti-Obesity and Weight Loss (1) Prostatic Neoplasms (4), more mentions
... randomized phase II study was performed to measure the potential therapeutic effects of yoga on fatigue, erectile dysfunction, urinary incontinence, and overall quality of life (QOL) in prostatecancer (PCa) patients undergoing external beam radiation therapy (RT) AbstractText: The participants were randomized to yoga and no-yoga cohorts (1:1.
Men's Health (3), Oncology (2), Urology (2) Prostatic Neoplasms (2), Urinary Incontinence (2), Erectile Dysfunction (2), more mentions
We demonstrate the successful detection of analytes relevant to mRNAs present in Alzheimer's disease as well as prostatecancer in human blood serum. The high performance and relative simplicity of the upconversion NP-graphene sensor platform enables new opportunities in early diagnosis based on specific detection of oligonucleotide sequences in complex environments Keyword: DNA.
... found to exist across diverse therapy-resistant states characterized by high expression of ZEB1, including epithelial-mesenchymal transition in epithelial-derived carcinomas, TGFβ-mediated therapy-resistance in melanoma, treatment-induced neuroendocrine transdifferentiation in prostatecancer, and sarcomas, which are fixed in a mesenchymal state owing to their cells of origin.
Oncology (8) Neoplasms (6), Melanoma (1), Carcinoma (1), more mentions
Moreover, SIRs were significantly higher for prostatecancer (SIR=1.07, 95%CI 1.03-1.11) and non-Hodgkin lymphoma ... Increase in risk was greater in male farm workers for prostate and lip cancer, in female farm workers for skin melanoma, and in male ... incidence for tobacco-related cancers and an increased incidence of prostatecancers, skin melanoma and multiple myeloma.
The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostatecancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells.