... on the prognostic value of size and RTI has significant limitations, so prudency is warranted on their routine use in clinical practice AbstractText: Primary testiculartumour size and rete testis invasion are considered to be important prognostic factors for the risk of relapse in patients with clinical stage I seminoma ...
Oncology (1) Seminoma (7), Testicular Neoplasms (1), more mentions
AbstractText: Some high-grade urothelialcarcinomas (UCs) in urine cytology can have jet black, smooth, or glassy chromatin, but ... cells, had rounder but still irregular nuclei, and also had frequent necrosis AbstractText: Malignanturothelial cells in urine cytology with jet black chromatin are common and can be ... Keyword: urothelialcarcinoma.
Oncology (3) Necrosis (3), Carcinoma (3), Neoplasms (2), more mentions
... RR = 4.79, 95% CI = 4.20 to 5.46, P < .001 for bladdercancer in men; RR = 6.43, 95% CI = 5.49 to 7.54, P < .001 for bladdercancer in women ... latency acute myocardial infarction mortality increases had subsided AbstractText: Lung, bladder, and kidneycancer mortality due to arsenic exposure have very long latencies, with ...
Abstract: Bladdercancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease... Comparison with muscle-invasive bladdercancer mutation profiles revealed lower overall mutation rates and more frequent mutations in RHOB and chromatin modifier genes... Keyword: bladdercancer. Keyword: gender. Keyword: genomics.
Oncology (4) Urinary Bladder Neoplasms (4), Neoplasms (2), more mentions
... is currently the most effective intravesical therapy for nonmuscle invasive bladdercancer, reducing not only recurrence rates but also preventing progression and ... of the immune response to BCG and the heterogeneity of bladdercancer suggest that future studies should amalgamate measures reflecting innate immune ... is an effective treatment for many patients with nonmuscle invasive bladdercancer.
Oncology (5) Neoplasms (8), Urinary Bladder Neoplasms (4), Carcinoma in Situ (1), more mentions
AbstractText: The role of surgery in metastatic bladdercancer (BCa) is unclear AbstractText: In this collaborative review article, we reviewed the contemporary literature on the surgical management ... surgery should be discussed with the patient among other consolidation therapies in the setting of multidisciplinary teams Keyword: Bladdercancer... Keyword: Metastatic bladdercancer.
Oncology (8) Urinary Bladder Neoplasms (4), Neoplasms (1), more mentions
AbstractText: Human papillomavirus (HPV) vaccines can potentially prevent greater than 90% of cervical and anal cancers as well as a substantial proportion of vulvar, vaginal, penile, and oropharyngeal cancers caused by certain HPV types. Because more than 38,000 HPV-associated cancers are diagnosed annually in the United States, current studies are needed to understand how relative survival varies for ...
... Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA. AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelialcancers (UTUCs. AA-associated kidney failure and UTUCs are prevalent in Taiwan, but AA's role in hepatocellular carcinomas (HCCs) there remains unexplored.
In addition to the reported associations of Hepatitis B and C virus (HBV & HCV) with liver cancer, and Human papillomaviruses (HPV) with cervical cancer and a subset of head and neck cancers, we found additional cases of HPV integrated in a small number of bladdercancers. Gene expression and mutational profiles suggest that HPV drives tumorigenesis in these cases Keyword ...
Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs negative selection during cancer development. On average, <1 coding base substitution/tumor is lost through negative selection, with purifying selection almost absent outside homozygous loss of essential genes. This allows exome-wide enumeration of all driver coding mutations, including outside known cancer genes. On average, tumors carry ∼4 coding substitutions under positive selection, ranging from <1/tumor in thyroid and testicularcancers to >10/tumor in endometrial and colorectal cancers. Half of driver substitutions occur in yet-to-be-discovered cancer genes. With increasing mutation burden, numbers of driver mutations increase, but not linearly. We systematically catalog cancer genes and show that genes vary extensively in what proportion of mutations are drivers versus passengers.
... and include other features that facilitate deep exploration of the biology behind the image. Here, we describe an implementation of the NG-CHM system in the Galaxy bioinformatics platform. We illustrate the algorithm and available computational tool using RNA-seq data from The Cancer Genome Atlas program's Kidney Clear Cell Carcinoma project. Cancer Res; 77(21); e23-26. 2017 AACR.