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Gastric Cancer
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Your search returned 11 results
from the time period: last 90 days.
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The Lancet. Oncology 
... in a phase 2 study in Asian patients with advanced gastric cancer, especially in those with ataxia-telangiectasia mutated protein (ATM)-negative ... 18 years or older (≥20 years if Japanese) with advanced gastric cancer that had progressed following, or during, first-line chemotherapy... overall or ATM-negative population of Asian patients with advanced gastric cancer.
Oncology (4)
Stomach Neoplasms (4), Neutropenia (2), Ataxia (1), more mentions
PLoS pathogens 
DescriptorName: Stomach Neoplasms... Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy... atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk.
Immune System Diseases (8), Oncology (1)
Atrophic Gastritis (12), Gastritis (2), Stomach Neoplasms (2), more mentions
The Cochrane database of systematic reviews 
AbstractText: Gastric cancer is the fifth most common cancer worldwide... versus single-agent chemotherapy and different chemotherapy combinations in advanced gastric cancer AbstractText: We searched the Cochrane Central Register of Controlled Trials ... versus single-agent chemotherapy and different chemotherapy regimens in advanced gastric cancer AbstractText: Two review authors independently identified studies and extracted data ...
Oncology (8)
Stomach Neoplasms (6), Neoplasms (1), more mentions
Lancet (London, England) 
... of programmed death-1 (PD-1), in patients with advanced gastric or gastro-oesophageal junction cancer who had been previously been treated with two or more ... eligible patients (aged ≥20 years with unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, standard therapy [including two or ...
Oncology (7)
Neoplasms (6), more mentions
Gut 
AbstractText: Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy, particularly in Helicobacter pylori (HP)-infected subjects. We determined the association between PPIs use and gastric cancer (GC) among HP-infected subjects who had received HP therapy AbstractText: This study was based on a territory-wide health database of Hong Kong... Keyword: stomach cancer.
Oncology (3)
Stomach Neoplasms (3), Adenocarcinoma (1), Atrophy (1), more mentions
Gastroenterology 
BACKGROUND & AIMS: Helicobacter pylori is remarkable for its genetic variation. Yet little isknown about its genetic changes during early stages of human infection, as the bacteria adapt to their new environment. We analyzed genome and methylome variations in a fully virulent strain of H pylori strain during experimental infection. METHODS: We performed a randomized Phase 1 and 2, observer-blind, placebo-controlled, study of 12 healthy, H pylori-negative adults in Germany from October 2008 through March 2010. The volunteers were given a prophylactic vaccine candidate (n=7) or placebo (n=5) and then challenged with H pylori strain BCM-300. Biopsy samples were collected and H pylori were isolated. Genomes of the challenge strain and 12 re-isolates, obtained 12 weeks after (or in 1 case, 62 weeks after) infection were sequenced by single-molecule, real-time technology, which, in parallel, permitted determination of genome-wide methylation patterns for all strains. Functional effects of genetic changes observed in H pylori strains during human infection were assessed by measuring release of interleukin 8 from AGS cells (to detect cag PAI function), neutral red uptake (to detect vacuolating cytotoxin activity), and adhesion assays. RESULTS: The observed mutation rate was in agreement with rates previously determined from patients with chronic H pylori infections, without evidence of a mutation burst. A loss; of cag PAI function was observed in 3 re-isolates. In addition, 3 re-isolates from the vaccine; group acquired mutations in the vacuolating cytotoxin gene vacA, resulting in loss of; vacuolization activity from gastric epithelial cells. We observed inter-strain variation in; methylomes due to phase variation in genes encoding methyltransferases. CONCLUSIONS: We analyzed adaptation of a fully virulent strain of H pylori to 12 differentvolunteers to obtain a robust estimate of the frequency of genetic and epigenetic changes inthe absence of inter-strain recombination. Our findings indicate that the large amount of; genetic variation in H pylori poses a challenge to vaccine development. ClinicalTrials.gov no: NCT00736476.
Vaccines (3), Oncology (1)
Infections (6), Neoplasms (1), more mentions
Gut 
This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy... composition of the gastric microbiota in chronic gastritis and in gastric carcinoma AbstractText: The gastric microbiota was retrospectively investigated in 54 patients with gastric carcinoma and 81 patients with chronic gastritis by 16S rRNA gene ...
Oncology (1)
Carcinoma (8), Gastritis (5), Infections (1), more mentions
Nature reviews. Gastroenterology & hepatology 
Gastric cancer: The gastric microbiota - bacterial diversity and implications..
Oncology (2)
Stomach Neoplasms (2), more mentions
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 
... insurance claims, we identified patients with cancer undergoing curative-intent surgery from 2010 to 2014. We included melanoma, breast, colorectal, lung, esophageal, and hepato-pancreato-biliary/gastric cancer. Primary outcomes were new persistent opioid use (opioid-naïve patients who continued filling opioid prescriptions 90 to 180 days after surgery) and daily opioid dose (evaluated monthly during the year after surgery.
Oncology (6)
Neoplasms (4), Melanoma (1), Stomach Neoplasms (1), more mentions
Annual review of nutrition 
Three nutrient associations had highly suggestive evidence and another 15 associations had suggestive evidence. Among the examined gene-diet interactions, only one had moderately strong evidence Keyword: breast cancer. Keyword: cancer. Keyword: colorectal cancer. Keyword: diet. Keyword: genes. Keyword: interaction. Keyword: lung cancer. Keyword: nutrigenetics. Keyword: prostate cancer. Keyword: stomach cancer.
Oncology (10)
Neoplasms (4), Colorectal Neoplasms (2), Lung Neoplasms (1), more mentions
Scientific reports 
High intake of carbohydrate from high GI foods was significantly associated with increased risk of colon and diabetes-related cancers, but decreased risk of stomach cancer; whereas high intake of carbohydrates from low GI foods was associated with reduced colon cancer risk. In a Mediterranean population with high and varied carbohydrate intake, carbohydrates that strongly raise postprandial blood glucose may ...
Oncology (9), Endocrine Disorders (3)
Neoplasms (3), Diabetes Mellitus (3), Colonic Neoplasms (2), more mentions