... 95% confidence interval [95% CI], 0.48-0.52) and smallest for rectaltumors in ages 50 to 64 years (male IRR, 0.91; 95 ... with the decrease exceeding 5% annually in 7 states; however, rectaltumor incidence in those ages 50 to 64 years was stable ... 2017 American Cancer Society Keyword: colon and rectumneoplasms.
Patients with increased numbers of tumor-infiltrating lymphocytes in primary colontumors and liver metastases have improved outcomes... that the immunostimulatory cytokine LIGHT (TNFSF14) in the microenvironment of coloncancer metastases associates with improved patient survival, and here we demonstrate in an immunocompetent murine model that colontumors expressing LIGHT stimulate lymphocyte proliferation and tumor-cell specific anti ...
Oncology (4) Neoplasms (16), Colonic Neoplasms (4), more mentions
... is occasionally found in clinical stage II or III lower rectalcancer, and ME with LLND is the standard procedure in Japan ... ME alone, however, is the international standard surgical procedure for rectalcancer AbstractText: Eligibility criteria included histologically proven rectalcancer at clinical stage II/III; main lesion located in the ...
... phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversification. Unlike the variegated pattern found in colorectalcancers, a large proportion of HCC display a clear isolation-by-distance pattern where spatially closer sectors are genetically more similar. Two resected intra-hepatic metastases showed genetic divergence occurring before and after primary tumour diversification, respectively.
... with a higher risk of developing oesophageal adenocarcinoma; colon and rectalcancer in men; biliary tract system and pancreatic cancer; endometrial cancer ... relative risk 1.09, 95% confidence interval 1.06 to 1.13) for rectalcancer among men to 56% (1.56, 1.34 to 1.81) for biliary ... when categorical measures of adiposity were included: weight gain with colorectalcancer; body mass index with gallbladder, gastric cardia, and ovarian cancer ...
Oncology (22), Anti-Obesity and Weight Loss (4) Neoplasms (8), Multiple Myeloma (3), Endometrial Carcinoma (3), more mentions
We performed an unbiased analysis of transcriptional heterogeneity in colorectaltumors and their microenvironments using single-cell RNA-seq from 11 primary colorectaltumors and matched normal mucosa... Notably, colorectaltumors previously assigned to a single subtype on the basis of bulk transcriptomics could be divided into subgroups with divergent ...
Oncology (2) Neoplasms (6), Colorectal Neoplasms (4), more mentions
AbstractText: Failing to complete chemotherapy adversely affects survival in patients with colorectalcancer... long-term mortality (adjusted hazard ratio, 0.70; 95% CI, 0.59-0.84; P < .001) AbstractText: Achieving a target radiation dose of 45.0 to 50.4 Gy is associated with a survival benefit in patients with locally advanced rectalcancer.
... TAMIS is an advanced transanal platform that can result in high quality LE of rectal neoplasia AbstractText: Consecutive patients from July 1, 2009 to December 31, 2015 from a prospective institutional registry were analyzed. Indication for TAMIS LE was endoscopically unresectable benign lesions or histologically favorable early rectalcancers. The primary endpoints were resection quality, neoplasia recurrence, and oncologic outcomes.
Oncology (1) Neoplasms (5), Adenocarcinoma (2), Hemorrhage (1), more mentions
Abstract: In patients with colorectalcancer (CRC) that metastasizes to the liver, there are several key ... continue to advance clinically and technologically in the field of colorectaltumor biology, our goal should be continued refinement of predictive and ... Keyword: CRC, colorectalcancer. Keyword: CRLM, colorectalcancer liver metastasis... Keyword: ColorectalCancer Liver Metastasis.
... western blot analyses revealed the involvement of different protein kinases in the ligand-dependent signaling pathway. Receptor knockdown via shRNA was used to analyze the involvement of OR51B4. We identified OR51B4, which is highly expressed in the coloncancer cell line HCT116 and in native human coloncancer tissues... The findings provide the basis for alternative treatments of colorectalcancer.
Using a metric called methylation haplotype load, we performed tissue-specific methylation analysis at the block level. Subsets of informative blocks were further identified for deconvolution of heterogeneous samples. Finally, using methylation haplotypes we demonstrated quantitative estimation of tumor load and tissue-of-origin mapping in the circulating cell-free DNA of 59 patients with lung or colorectalcancer.
Oncology (1) Neoplasms (2), Colorectal Neoplasms (1), more mentions
... 0.03) AbstractText: Despite being used in lower risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe. This article is protected by copyright. All rights reserved Keyword: anastomotic leak. Keyword: colorectalcancer. Keyword: crohn's disease. Keyword: epidemiology. Keyword: international.
Immune System Diseases (2), Oncology (1) Anastomotic Leak (4), Colorectal Neoplasms (1), more mentions
DescriptorName: ColorectalNeoplasms... Abstract: Healthy People 2020 (HP2020) includes objectives to increase screening for breast, cervical, and colorectalcancer (1) as recommended by the U.S. Preventive Services Task Force (USPSTF).* Progress toward ... Although colorectalcancer screening test use increased from 2000 to 2015, no improvements in test use were ...