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Bone Marrow/Stem Cell Transplantation
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Your search returned 58 results
from the time period: last 90 days.
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The Lancet. Oncology 
... possible benefit of intensification with high-dose chemotherapy and autologous stem-cell transplantation as part of first-line treatment in these patients AbstractText ... dose BEAM chemotherapy (carmustine, etoposide, cytarabine, and melphalan) plus autologous stem-cell transplantation (transplantation group) in young patients (18-65 years) with untreated ... melphalan 140 mg/m(2) on day -2) and autologous stem-cell transplantation (day 0); or R-MegaCHOP-14 for four cycles followed by R-MAD plus BEAM and autologous stem-cell transplantation ...
Diffuse Large B-Cell Lymphoma (5), more mentions
DescriptorName: Hematopoietic Stem Cell Transplantation... AbstractText: Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT. Previous studies have suggested that azithromycin may reduce the incidence of post-lung transplant bronchiolitis obliterans syndrome AbstractText: To evaluate if the early administration of azithromycin can improve airflow decline-free survival after allogeneic HSCT AbstractText ...
Stem Cell Research (3)
Bronchiolitis Obliterans (5), Hematologic Neoplasms (3), more mentions
Cell reports 
Systems-level analyses offer increased power to sort patients on the basis of coordinated changes across immune cells and proteins. Allogeneic stem cell transplantation is a well-established form of immunotherapy whereby a donor immune system induces a graft-versus-leukemia response... Keyword: bone marrow transplantation... Keyword: stem cell transplantation. Keyword: systems immunology.
Oncology (3)
Leukemia (3), Neoplasms (1), Infections (1), more mentions
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abstract: Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product.
Immune System Diseases (2), Infectious Diseases (1)
Infections (7), Adenoviridae Infections (1), Hematuria (1), more mentions
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abstract: Purpose Lenalidomide maintenance therapy after autologous stem-cell transplantation (ASCT) demonstrated prolonged progression-free survival (PFS) versus placebo or observation in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma (NDMM. All studies had PFS as the primary end point, and none were powered for overall survival (OS) as a primary end point.
Oncology (4)
Multiple Myeloma (2), Leukemia (1), Neoplasms (1), more mentions
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose Inpatient palliative care integrated with transplant care improves patients' quality of life (QOL) and symptom burden during hematopoietic stem-cell transplant (HCT... mood, PTSD symptoms, and QOL with the Hospital Anxiety and Depression Scale and Patient Health Questionnaire, PTSD checklist, and Functional Assessment of Cancer Therapy-Bone Marrow Transplant.
Oncology (1)
Post-Traumatic Stress Disorders (7), Depressive Disorder (5), Hematologic Neoplasms (1), more mentions
AbstractText: Lung transplantation is the final life-saving option for patients with pulmonary complications after hematopoietic stem cell transplantation (HSCT. Patients undergoing HSCT for hematologic diseases are thought to be high-risk candidates for lung transplantation; therefore, few lung transplants are performed for these patients, and few studies have been reported.
Hematologic Neoplasms (1), Hypercapnia (1), Hematologic Diseases (1), more mentions
Infection control and hospital epidemiology
Clinical Care of Hematological Patients in a Bone Marrow Transplant Unit: Do Human Resources Influence Infection Incidence?.
Infections (2), more mentions
Journal of neurology, neurosurgery, and psychiatry
Autologous haematopoietic stem cell transplantation is a treatment approach that aims to ameliorate and to ... Available data suggest that autologous haematopoietic stem cell transplantation is superior to conventional treatment in terms of efficacy with ... current data on clinical effect and safety of autologous haematopoietic stem cell transplantation for neurological disease are reviewed Keyword: clinical neurology.
Stem Cell Research (5), Immune System Diseases (3), Neuroscience (1)
Multiple Sclerosis (3), Polyneuropathies (1), Myasthenia Gravis (1), more mentions
The Journal of allergy and clinical immunology
Abstract: In the largest detailed study of liver disease in X-linked immunodeficiency with hyper-IgM, we show that liver disease is commoner than generally recognized and that early hematopoietic stem cell transplantation may prevent liver disease progression and improve survival Keyword: CD40 ligand deficiency... Keyword: hematopoietic stem cell transplant.
Infectious Diseases (1)
Liver Diseases (4), Chronic Hepatitis (1), Sclerosing Cholangitis (1), more mentions
Infection control and hospital epidemiology
... with vancomycin-resistant Enterococcus (VRE) molecular strain typing and environmental cultures. SETTING A regional referral center for acute leukemia and hematopoietic stem-cell transplantation. PATIENTS Overall, 536 consecutive hospital admissions for newly diagnosed acute leukemia or a first autologous or allogeneic stem-cell transplantation were reviewed. INTERVENTION During 2009-2010, our unit underwent complete remodeling including replacement of all surfaces.
Oncology (2)
Leukemia (2), Infections (2), Hematologic Neoplasms (1), more mentions
Nature medicine
... on the role of the bacterial microbiome in human health, but the virome is understudied. Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell transplantation (HSCT) and enteric graft-versus-host disease (GVHD) remain unexplored. Here we characterize the longitudinal gut virome in 44 recipients of HSCT using metagenomics.
Infectious Diseases (1)
Graft vs Host Disease (2), Inflammatory Bowel Diseases (1), Infections (1), more mentions
The Lancet. Oncology
Ready-to-use T cells for infection after stem-cell transplant..
Infections (2), more mentions
The British journal of dermatology
Graft versus host disease (GVHD) is a common, morbid, and potentially fatal complication of allogeneic hematopoietic stem cell transplantation (aHSCT).(1-3) The exact timing of the arrival of donor-derived immune cells and their profile in the skin have not been well described in humans.(4-6) Fluorescent in ...
The Journal of allergy and clinical immunology
We describe a compensatory expansion of activated cytotoxic CD56(bright) NK cells during T-cell deficiency after hematopoietic stem cell transplantation. This mimics the situation in severe inborn T-cell deficiencies and unmasks the functional and phenotypic versatility of NK cells..
The Lancet. Oncology
High-dose chemotherapy and autologous stem-cell transplantation for DLBCL in the rituximab era..
Hematologic relapse in AL amyloidosis after high-dose melphalan and stem cell transplantation..
Amyloidosis (2), more mentions
Autologous hematopoietic stem cell transplantation in multiple sclerosis: A meta-analysis..
Immune System Diseases (2)
Multiple Sclerosis (2), more mentions
Among patients with immunoglobulin light chain (AL) amyloidosis, there is little consensus on when reinstitution of chemotherapy should occur. We conducted a retrospective study to evaluate the patterns of relapse or progression (R/P) and the timing of re-initiating therapy among 235 patients initially treated with ASCT at Mayo Clinic. The median time from ASCT to second-line therapy was 24.3 months. At the time of restarting therapy, median dFLC was 9.9 mg/dL (42% of diagnosis value); 32% had a dFLC< 5mg/dL; and 63% met criteria for organ R/P. The indications for re-treatment were: 1) clinical suspicion of R/P, 10%; 2) hematologic R/P only, 23%; 3) organ R/P only 32%; 4) both hematologic and organ R/P, 31%; 5) suboptimal response to ASCT and second-line therapy as consolidation 4%. Patients with organ progression at the time of second line therapy had inferior survival. Although a dFLC of more than 5 mg/dL at the time of reinstituting therapy was associated with risk, patients relapsing from VGPR or better had longer time to develop organ progression after hematologic R/P (24.2 vs 3.2 months, p=0.007). These data suggest that the best candidates for clinical trials testing novel plasma cell directed chemotherapy beyond first line may be those patients who either are relapsing from VGPR or better (dFLC at diagnosis was >5 mg/dL) or are having inadequate response to prior therapy. This strategy should allow for hematologic response assessment whilst avoiding the risk of deleterious organ progression. Implementation of more stringent progression criteria may also be warranted.
Amyloidosis (2), more mentions
Journal of clinical microbiology
Abstract: A viral whole genome sequencing strategy, based on PCR amplification followed by Next-generation Sequencing, was used to investigate a nosocomial RSV-B outbreak in a hematology-oncology and stem cell transplant unit. RSV-B genomes from 16 patients and healthcare workers (HCWs) suspected to be involved in the outbreak were compared to RSV-B genomes acquired from outpatients ...
Blood Disorders and Hematology (1), Oncology (1), more mentions
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