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Neurotoxicology
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Your search returned 21 results
from the time period: last 30 days.
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Alcoholism, clinical and experimental research
... fulfilled the DSM-5 criteria for Alcohol-Induced Mild Neurocognitive Disorder, and one group was diagnosed with Korsakoff's syndrome (Alcohol-Induced Major Neurocognitive Disorder, Confabulatory/Amnesic subtype; DSM-5... implicit learning in both groups AbstractText: 51 Inpatients with a mild neurocognitive disorder and 54 inpatients with Korsakoff's syndrome were trained.
Neuroscience (1)
Alcoholism (1), more mentions
Medicine
DescriptorName: Neuroleptic Malignant Syndrome... AbstractText: Neuroleptic malignant syndrome (NMS) is a life threatening neurologic emergency associated with neuroleptic or antipsychotic agent use. NMS is rarely related to thyroid disease AbstractText: We report a case of NMS in a 66-year-old male with past medical history of paranoid schizophrenia on chlorpromazine, diabetes, hypertension and asthma, who presented with a humeral ...
Neuroscience (2), Cardiovascular Diseases (1), Endocrine Disorders (1)
Neuroleptic Malignant Syndrome (10), Hypothyroidism (3), Asthma (1), more mentions
The American journal of emergency medicine
No Abstract Available
Smoking Cessation (2), more mentions
The American journal of emergency medicine
No Abstract Available
Smoking Cessation (2), more mentions
Cancer discovery 
... higher before treatment in patients who subsequently developed grade ≥4 neurotoxicity.SIGNIFICANCE: We provide a detailed clinical, radiologic, and pathologic characterization of neuro-toxicity after CD19 CAR-T cells, and identify risk factors for neurotoxicity ... We show endothelial dysfunction and increased BBB permeability in neurotoxicity and find that patients with evidence of endothelial activation before lymphodepletion may be at increased risk of neurotoxicity ...
Oncology (2)
Precursor Cell Lymphoblastic Leukemia-Lymphoma (1), Neoplasms (1), more mentions
British journal of haematology
A 14-year-old boy with relapsed T cell acute lymphoblastic leukaemia received reinduction chemotherapy that included nelarabine, a purine nucleoside analogue known to cause dose-dependent neurotoxicity. Although he achieved aminimal residual disease negative remission after two cycles of chemotherapy he also developed severe, progressive peripheral and central neurotoxicities.
British journal of anaesthesia
Reproducibility of science and developmental anaesthesia neurotoxicity: a tale of two cities..
British journal of anaesthesia
Anaesthesia-induced developmental neurotoxicity: reality or fiction?.
British journal of anaesthesia
Theseus, the Labyrinth, and the Minotaur of anaesthetic-induced developmental neurotoxicity..
British journal of anaesthesia
Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity..
Cancer
... responsive to radiation therapy; however, whole-brain radiotherapy (WBRT) inadequately controls the disease when it is used alone, and its delayed neurotoxicity causes neurocognitive impairment, especially in elderly patients... induction chemotherapy with or without autologous stem cell transplantation (ASCT) or reduced-dose WBRT leads to durable disease control and less neurotoxicity.
Oncology (4), Stem Cell Research (1)
Neoplasms (3), Lymphoma (2), Non-Hodgkin Lymphoma (1), more mentions
Human molecular genetics
... that NCEH-1 protects dopaminergic neurons from α-synuclein-dependent neurotoxicity in C. elegans via a mechanism that is independent of ... In protecting from α-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers ... metabolism can modulate a neuroprotective mechanism that attenuates α-synuclein neurotoxicity, thereby pointing toward regulation of neuronal cholesterol turnover as a ...
Neurological and Central Nervous System Diseases (2)
Parkinson Disease (2), Neurodegenerative Diseases (1), more mentions
Neuro-oncology
However, newer agents may produce toxicities that may seem indistinguishable from the underlying cancer. Early recognition of neurotoxicities from new therapeutics is vital to avoid irreversible neurological injury. This review focuses on cancer therapies in use in the last ten years and approved by the United States Food and Drug Administration from January 2006 through January 1, 2017.
Oncology (4)
Neoplasms (5), more mentions
International journal of radiation oncology, biology, physics
Four patients (5%) developed acute radiation-induced neurotoxicity (grade [G] 1, n=1; G2, n=3... sSC Dmax and D2%, cSC Dmax and D2%, or the length of CTV and toxicity AbstractText: High-dose conformal PBSPT may be delivered safely in close proximity to the spinal cord with minimal neurotoxicity.
Chondrosarcoma (2), Chordoma (2), Spinal Cord Compression (1), more mentions
The Journal of neuroscience : the official journal of the Society for Neuroscience
... capacity to induce the UPR(MT), but also that coexpression of αS and ATFS-1-associated dysregulation of the UPR(MT) synergistically potentiate dopaminergic neurotoxicity... consequences of prolonged cellular activation of the UPR(MT) we provide evidence that this pathway is not a universally beneficial mechanism, since dysregulation has neurotoxic consequences.
Neurological and Central Nervous System Diseases (2)
Neurodegenerative Diseases (3), Parkinson Disease (2), more mentions
Proceedings of the National Academy of Sciences of the United States of America 
Accordingly, MAO-B inhibitor rasagiline disrupts α-Syn/TrkB complex and rescues TrkB neurotrophic signaling, preventing α-Syn-induced dopaminergic neuronal death and restoring motor functions. Hence, our findings demonstrate a noble pathological role of α-Syn in antagonizing neurotrophic signaling, providing a molecular mechanism that accounts for its neurotoxicity in PD Keyword: Lewy bodies. Keyword: dopamine.
Neurological and Central Nervous System Diseases (2)
Parkinson Disease (2), Neurodegenerative Diseases (1), more mentions
Nature reviews. Clinical oncology 
Neurotoxicity, termed CAR-T-cell-related encephalopathy syndrome (CRES), is the second most-common adverse event, and can occur concurrently with or after CRS. Intensive monitoring and prompt management of toxicities is essential to minimize the morbidity and mortality associated with this potentially curative therapeutic approach; however, algorithms for accurate and consistent grading and management of the toxicities are lacking.
Neuro-oncology
Neurotoxicity, including radiation-induced brain volume reduction, could be one reason why not all patients benefit from the addition of WBRT. In this study, we quantified brain volume reduction after WBRT and assessed its prognostic significance.Brain volumes of 91 patients with cerebral metastases were measured during a 150-day period after commencing WBRT, and were compared to their pretreatment ...
Oncology (1), more mentions
PloS one
In addition to their role in amyloid processing, caspase-8 and its downstream effector caspase-3 are involved in synaptic plasticity, learning, memory and control of microglia pro-inflammatory activation and associated neurotoxicity, indicating additional mechanisms that might contribute to AD. As caspase inhibition has been proposed as a mechanism for AD treatment, our finding that AD-associated CASP8 variants ...
Neuroscience (2)
Alzheimer Disease (2), Neurodegenerative Diseases (1), more mentions
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
... aims to lay to rest.This review assesses evidence for and against each of the most common myths regarding BoNT use in aesthetics.BoNT-A neurotoxin/protein complexes are irrelevant to the toxin's therapeutic/aesthetic indications. BoNT-A neurotoxin/protein complexes do not influence movement from injection site or immunogenicity.
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