... hole pegboard) compared to normative data AbstractText: The present study has established a low likelihood of significant distal symmetrical polyneuropathy in colorectal cancer patients prior to initiation of chemotherapy. This article is protected by copyright. All rights reserved Keyword: Chemotherapy-induced peripheral neuropathy. Keyword: Colorectal cancer. Keyword: Neurophysiological assessments. Keyword: Neurotoxic chemotherapy. Keyword: Pre-existing neuropathy. Keyword: Subclinical peripheral neuropathy.
Oncology (5) Colorectal Neoplasms (5), Peripheral Nervous System Diseases (3), Polyneuropathies (1), more mentions
... encountered in many skin diseases, but the role of eosinophils in atopic dermatitis (AD) remains uncertain AbstractText: To examine the role of serum eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and total IgE as a biomarker of disease severity and relapse in severe recalcitrant AD AbstractText: We enrolled 99 patients ...
Dermatology (3) Atopic Dermatitis (3), Skin Diseases (1), more mentions
... that NCEH-1 protects dopaminergic neurons from α-synuclein-dependent neurotoxicity in C. elegans via a mechanism that is independent of ... In protecting from α-synuclein neurotoxicity, NCEH-1 also stimulates cholesterol-derived neurosteroid formation and lowers ... metabolism can modulate a neuroprotective mechanism that attenuates α-synuclein neurotoxicity, thereby pointing toward regulation of neuronal cholesterol turnover as a ...
Neurological and Central Nervous System Diseases (2) Parkinson Disease (2), Neurodegenerative Diseases (1), more mentions
MEDLINE/PubMed, EBSCO, and Google Scholar were searched through February 2017 using the search terms metronidazole and peripheral neuropathy, or polyneuropathy, or paresthesia, or neurotoxicity... Overall, metronidazole is generally well tolerated but serious neurotoxicity, including peripheral neuropathy, has been reported. The overall incidence of peripheral neuropathy associated with metronidazole is unknown.
Infectious Diseases (1) Peripheral Nervous System Diseases (11), Polyneuropathies (1), Paresthesia (1), more mentions
... systemic cardiac and toxicity levels reported as 2-4 μg/mL. There were no reported cardiac and neurotoxic events in any patients AbstractText: The use of full-dose PAI with liposomal bupivacaine placed into each knee during simultaneous bTKA is safe with systemic bupivacaine levels well below reported cardiac and neurotoxic levels Keyword: bilateral total knee arthroplasty. Keyword: bupivacaine toxicity.
We report a rare case of encephalopathy following treatment with pembrolizumab, where the patient achieved durable disease response despite discontinuation of therapy. We also review the pathophysiology, incidence, clinical presentation, diagnosis and management of neurotoxicity secondary to ICIs. Treatment requires early administration of high dose corticosteroids, and cessation of ICI therapy is often necessary after Grade 3-4 irAEs.
Here, we describe a case of delayed-onset CsA neurotoxicity presenting as opsoclonus-myoclonus syndrome (OMS).A 37-year-old woman with a two-week period of opsoclonus and upper extremity myoclonus was admitted to our hospital. The patient had been taking CsA for 17 years after receiving a kidney transplant.
Opsoclonus-Myoclonus Syndrome (2), Myoclonus (1), Opsoclonus (1), more mentions
... relaxant, is primarily excreted via the kidneys; toxicity is a potentially serious adverse outcome in patients with decreased kidney function. We describe a patient with end-stage kidney disease receiving hemodialysis who developed neurotoxicity and hemodynamic instability after receiving baclofen for muscle spasms. In this case, prompt recognition of baclofen toxicity and urgent hemodialysis were effective in reversing this toxicity.
Severe neutropenia appeared in some patients, although it was resolved by treatment in all. The most common nonhematological toxicity was anorexia (64%), followed by neurotoxicity and constipation. All nonhematological toxicities were mild and manageable.Our results suggest that chemotherapy with nab-paclitaxel regimens for relapsed SCLC exhibits moderate clinical efficacy and is well-tolerated.
Oncology (8), Blood Disorders and Hematology (1) Lung Neoplasms (2), Neutropenia (2), Anemia (1), more mentions
Accordingly, MAO-B inhibitor rasagiline disrupts α-Syn/TrkB complex and rescues TrkB neurotrophic signaling, preventing α-Syn-induced dopaminergic neuronal death and restoring motor functions. Hence, our findings demonstrate a noble pathological role of α-Syn in antagonizing neurotrophic signaling, providing a molecular mechanism that accounts for its neurotoxicity in PD.
Neurological and Central Nervous System Diseases (2) Parkinson Disease (2), more mentions
Neurotoxicity, termed CAR-T-cell-related encephalopathy syndrome (CRES), is the second most-common adverse event, and can occur concurrently with or after CRS. Intensive monitoring and prompt management of toxicities is essential to minimize the morbidity and mortality associated with this potentially curative therapeutic approach; however, algorithms for accurate and consistent grading and management of the toxicities are lacking.
In this study, we examined the effect of botulinum neurotoxin A (BoNT-A) injections to the cricopharyngeus muscle (CPM) of patients with s-IBM and dysphagia AbstractText: A single-center ... CPM alleviate the dysphagia of s-IBM patients reversibly and appear to reduce the rate of aspiration effectively Keyword: Botulinum neurotoxin.
Deglutition Disorders (9), Inclusion Body Myositis (3), Aspiration Pneumonia (1), more mentions
... who had experienced an immediate disappearance of HFS experienced a significantly higher occurrence of DFP than those who did not (odds ratio 0.383, 95% confidence interval 0.183-0.802; p = 0.011. In addition, preoperative botulinum neurotoxin injections negatively influenced the occurrence of DFP (p = 0.016. CONCLUSIONS In this study, the incidence rate of DFP was slightly higher than previously reported values.