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Multiple Sclerosis/Demyelinating Disease
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Your search returned 60 results
from the time period: last 30 days.
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Scientific reports 
Abstract: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS. There is currently no single definitive test for MS. Circulating exosomes represent promising candidate biomarkers for a host of human diseases. Exosomes contain RNA, DNA, and proteins, can cross the blood-brain barrier, and are secreted from almost all cell types including cells of ...
Immune System Diseases (2)
Multiple Sclerosis (10), Demyelinating Diseases (1), more mentions
... disease activity, disability, and disease-modifying therapies (DMTs) on serum neurofilament light (NFL) and the correlation between NFL concentrations in serum and CSF in multiple sclerosis (MS) AbstractText: NFL concentrations were measured in paired serum and CSF samples (n = 521) from 373 participants: 286 had MS, 45 had other neurologic ...
Immune System Diseases (2)
Multiple Sclerosis (9), more mentions
Nature reviews. Neurology 
Abstract: Remyelination in the CNS is the natural process of damage repair in demyelinating diseases such as multiple sclerosis (MS. However, remyelination becomes inadequate in many people with MS, which results in axonal degeneration and clinical disability. Enhancement of remyelination is a logical therapeutic goal; nevertheless, all currently licensed therapies for MS are immunomodulatory and do not support remyelination directly.
Immune System Diseases (2)
Multiple Sclerosis (6), Demyelinating Diseases (1), more mentions
... To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions ... CIS topographies AbstractText: Our results comply with the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) consensus recommendation of combining cortical and juxtacortical lesions into a single ...
Immune System Diseases (3)
Multiple Sclerosis (3), Optic Neuritis (2), more mentions
JAMA neurology 
Combating the Spread of Ineffective Medical Procedures: A Lesson Learned From Multiple Sclerosis..
Immune System Diseases (2)
Multiple Sclerosis (2), more mentions
JAMA neurology 
Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal angioplasty (PTA) is beneficial in persons with MS and CCSVI is controversial AbstractText: To determine the efficacy and safety of venous PTA in patients with MS and CCSVI AbstractText: We analyzed 177 patients with relapsing-remitting ...
Immune System Diseases (2)
Multiple Sclerosis (9), Venous Insufficiency (1), more mentions
AbstractText: To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS AbstractText: All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls ...
Neurological and Central Nervous System Diseases (12), Immune System Diseases (2)
Multiple Sclerosis (13), Epilepsy (12), more mentions
AbstractText: To evaluate the association between comorbidity and relapse rate in individuals with multiple sclerosis (MS) AbstractText: We recruited individuals with prevalent relapsing-onset MS from 4 Canadian MS Clinics to participate in a 2-year prospective multicenter cohort study involving cross-sectional assessment of comorbidities and relapses. Comorbidities were recorded using questionnaires, and relapses were captured from medical records ...
Pain Management (3), Immune System Diseases (2), Neuroscience (1)
Multiple Sclerosis (7), Migraine Disorders (3), Hyperlipidemias (3), more mentions
Alimentary pharmacology & therapeutics
Standardised incidence ratios for malignancies were similar to the general population (CD, 1.45 [95% CI, 0.90-2.22]; UC, 1.36 [95% CI, 0.84-2.07. Demyelinating disorders were uncommon (CD, 0.1 E/100 PYs; UC, <0.1 E/100 PYs) AbstractText: Patients with moderately to severely active Crohn's disease or ulcerative colitis continued to experience acceptable safety with adalimumab, without new safety signals.
Immune System Diseases (3), Cardiovascular Diseases (1), Infectious Diseases (1)
Ulcerative Colitis (3), Opportunistic Infections (1), Oral Candidiasis (1), more mentions
AbstractText: The 10-item Dysphagia in Multiple Sclerosis (DYMUS) questionnaire is a self-administered tool used to identify swallowing problems in adults with MS... Keyword: Multiple sclerosis. Keyword: Questionnaire. Keyword: Validation.
Immune System Diseases (3)
Multiple Sclerosis (6), Deglutition Disorders (5), more mentions
Neurodegenerative disease management 
Abstract: Spasticity, perceived by patients as muscle rigidity and spasms, is a common symptom in multiple sclerosis (MS... Keyword: multiple sclerosis. Keyword: spasticity management.
Immune System Diseases (3)
Multiple Sclerosis (6), Muscle Rigidity (1), more mentions
Frontiers in immunology 
Abstract: Pathogenesis of autoimmune disorders, including multiple sclerosis (MS), has been linked to an alteration of the resident microbial commensal community and of the interplay between the microbiota and the immune system... Keyword: multiple sclerosis.
Immune System Diseases (4)
Multiple Sclerosis (6), more mentions
Multiple sclerosis (Houndmills, Basingstoke, England) 
AbstractText: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage ... VO2max, sit-to-stand test, Six-Minute Walk Test (6MWT), Multiple Sclerosis Walking Scale-12 (MSWS-12)) and cognitive function (Rao's Brief ... Scale for Motor and Cognitive Function (FSMC)), quality of life (Multiple Sclerosis Impact Scale-29 (MSIS-29)), and imaging.
Immune System Diseases (5)
Multiple Sclerosis (5), more mentions
Multiple sclerosis (Houndmills, Basingstoke, England) 
Abstract: Exercise benefits multiple sclerosis (MS) patients, but exercise-induced overheating is a deterrent for many... Aspirin may represent an effective pretreatment for exercise in MS Keyword: Multiple sclerosis. Keyword: aspirin. Keyword: body temperature. Keyword: exercise. Keyword: fatigue.
Immune System Diseases (3)
Multiple Sclerosis (5), more mentions
International journal of MS care 
... is a well-recognized cause of facial pain in the general population, and multiple sclerosis (MS) accounts for some of these cases... AbstractText: In 2009, we surveyed participants in the North America Research Committee on Multiple Sclerosis Registry regarding TN, including date of onset and pharmacologic and nonpharmacologic treatments used ...
Immune System Diseases (3)
Multiple Sclerosis (13), Trigeminal Neuralgia (2), Facial Pain (1), more mentions
PLoS computational biology 
DescriptorName: Magnetic Resonance Imaging. DescriptorName: Multiple Sclerosis... Abstract: Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS. However, it is not well understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous disease. We established a hypothesis whereby the variability in the course of MS ...
Immune System Diseases (5)
Multiple Sclerosis (13), Autoimmune Diseases (1), more mentions
Scientific reports 
Abstract: Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a mechanistic basis remains largely unknown. We aimed at investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers and never smokers in two Swedish cohorts, differing for known ...
Immune System Diseases (2), Smoking Cessation (1)
Multiple Sclerosis (8), Neurodegenerative Diseases (1), more mentions
Pearls & Oy-sters: CNS lymphoma in a patient with relapsing-remitting multiple sclerosis treated with interferon..
Immune System Diseases (2)
Relapsing-Remitting Multiple Sclerosis (2), Lymphoma (2), more mentions
Brain : a journal of neurology
Cerebral X-linked adrenoleukodystrophy is a devastating neurodegenerative disorder caused by mutations in the ABCD1 gene, which lead to a rapidly progressive cerebral inflammatory demyelination in up to 60% of affected males. Selective brain endothelial dysfunction and increased permeability of the blood-brain barrier suggest that white matter microvascular dysfunction contributes to the conversion to cerebral disease. Applying a vascular model to conventional dynamic susceptibility contrast magnetic resonance perfusion imaging, we demonstrate that lack of ABCD1 function causes increased capillary flow heterogeneity in asymptomatic hemizygotes predominantly in the white matter regions and developmental stages with the highest probability for conversion to cerebral disease. In subjects with ongoing inflammatory demyelination we observed a sequence of increased capillary flow heterogeneity followed by blood-brain barrier permeability changes in the perilesional white matter, which predicts lesion progression. These white matter microvascular alterations normalize within 1 year after treatment with haematopoietic stem cell transplantation. For the first time in vivo, our studies unveil a model to assess how ABCD1 alters white matter microvascular function and explores its potential as an earlier biomarker for monitoring disease progression and response to treatment.
Stem Cell Research (1)
Demyelination (3), Adrenoleukodystrophy (3), Neurodegenerative Diseases (1), more mentions
... NMOSD prior to age 40 experienced their initial symptom during the 3 months postpartum, 2.9 times higher than expected AbstractText: The postpartum period is a particularly high-risk time for initial presentation of NMOSD. In contrast to published observations in multiple sclerosis, in neuromyelitis optica, relapse rate during pregnancy was also increased, although to a lesser extent than after delivery.
Immune System Diseases (1)
Neuromyelitis Optica (3), Multiple Sclerosis (1), more mentions
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